Cardiac Troponin C Proteins (TNNC1)

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Additionally we are shipping TNNC1 Antibodies (97) and TNNC1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNNC1 7134 P63316
Rat TNNC1 TNNC1 290561  
TNNC1 21924 P19123
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Top TNNC1 Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 20 to 21 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$407.00
Details
HOST_Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$460.85
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,365.00
Details
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$2,365.00
Details
Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$2,365.00
Details

TNNC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine)

More Proteins for Cardiac Troponin C (TNNC1) Interaction Partners

Human Cardiac Troponin C (TNNC1) interaction partners

  1. Data suggest that modulation of structural dynamics far from the regulatory Ca2 (show CA2 Proteins)+-binding site is the underlying molecular mechanism for many TNNC1 mutations in patients with hypertrophic cardiomyopathies or familial hypertrophic cardiomyopathies; many mutations affect balance between open and closed conformations; troponin I switch peptide [TnI (show TNNI2 Proteins)(SW)] switch peptide binds to TNNC1 and stabilizes the open TNNC1 conformation.

  2. Data suggest that mutations in troponin C (TnC (show TNNC2 Proteins)) found in patients with hypertrophic cardiomyopathy (A8V, C84Y, and D145E) stabilize the active state of regulated actin (the actin-tropomyosin (show TPM2 Proteins)-troponin complex) to various extents; at a saturating Ca2 (show CA2 Proteins)+ concentration, all TnC (show TNC Proteins) mutants investigated increase the level of active M state compared to the wild type.

  3. There was no difference in the test characteristics of the HEART Pathway whether using cTnI or hs-cTnI, with both achieving 100% sensitivity and NPV. Use of hs-cTnT with the HEART Pathway was associated with one missed major adverse cardiac events.

  4. contractility is constantly above normal in hearts made hypertrophic by TnC (show TNC Proteins) with the A8V mutation

  5. We used nuclear magnetic resonance and circular dichroism to solve the structure and characterize the backbone dynamics and stability of the regulatory domain of cTnC with the L29Q mutation.

  6. conclusive evidence that TNNC1 is an uncommon but definitive HCM-susceptibility gene

  7. Troponin C (TnC) and the N-terminal helix of Troponin I (TnI N-helix), which occurs in vivo during muscle contraction.

  8. FAK (show PTK2 Proteins)/CREB (show CREB1 Proteins)/TNNC1 has a role in mediating the effect of stromal MFAP5 (show MFAP5 Proteins) on ovarian cancer metastatic potential

  9. Mutations in cTnC have been associated with hypertrophic or dilated cardiomyopathy.[review]

  10. Data suggest that mutation A162H in switch region of troponin I induces transitory curved conformation and promotes contraction of troponin I bound to regulatory domain of troponin C; this is countered by residue E164 to ensure proper relaxation.

Cow (Bovine) Cardiac Troponin C (TNNC1) interaction partners

  1. These results demonstrate that the L29Q mutation enhances the Ca(2+)-binding characteristics of cTnC and that when incorporated into cardiac myocytes, this mutant alters myocyte contractility.

Mouse (Murine) Cardiac Troponin C (TNNC1) interaction partners

  1. Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle.

  2. A region in cTnC associated with increased Ca(2+) sensitivity in skinned fibers was identified, an the F27W reporter mutation affected Ca(2+) sensitivity, maximal force, and ATPase activation of some mutants.

  3. Overexpression of sTnC (show TNNC2 Proteins) polypeptide in muscle cells is controlled by its rapid degradation.

  4. These results demonstrate that the L29Q mutation enhances the Ca(2+)-binding characteristics of cTnC and that when incorporated into cardiac myocytes, this mutant alters myocyte contractility.

TNNC1 Protein Profile

Protein Summary

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase\; TnT, which contains the binding site for tropomyosin\; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z.

Gene names and symbols associated with Cardiac Troponin C Proteins (TNNC1)

  • troponin C type 1 (slow) (tnnc1)
  • cardiac troponin C (tnnc1)
  • troponin C type 1 (slow) (TNNC1)
  • troponin C type 1 (slow) (Tnnc1)
  • troponin C, cardiac/slow skeletal (Tnnc1)
  • troponin C, slow (LOC100347570)
  • AI874626 protein
  • CMD1Z protein
  • CMH13 protein
  • cTnC protein
  • cTnI protein
  • MGC80066 protein
  • PCTNC1 protein
  • TN-C protein
  • TnC protein
  • tncc protein
  • TNNC protein
  • TNNC1 protein

Protein level used designations for Cardiac Troponin C Proteins (TNNC1)

cardiac troponin C , slow twitch skeletal/cardiac muscle troponin C , troponin C, slow skeletal and cardiac muscles , troponin C1, slow , troponin C, cardiac/slow skeletal , TN-C , Troponin C, slow skeletal and cardiac muscles

GENE ID SPECIES
379410 Xenopus laevis
399104 Xenopus laevis
7134 Homo sapiens
290561 Rattus norvegicus
396032 Gallus gallus
100156435 Sus scrofa
509486 Bos taurus
21924 Mus musculus
100347570 Oryctolagus cuniculus
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