Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) Proteins (CNDP1)

CNDP1 encodes a member of the M20 metalloprotease family. Additionally we are shipping Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) Antibodies (89) and Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CNDP1 84735 Q96KN2
CNDP1 338403 Q8BUG2
Rat CNDP1 CNDP1 307212 Q66HG3
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Top Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 20 to 21 Days
$206.80
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
$437.80
Details
HOST_HEK-293 Cells Human His tag Human CNDP1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Log in to see 2 to 3 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$522.50
Details
HOST_HEK-293 Cells Human His tag Validation with Western Blot 10 μg Log in to see 12 to 15 Days
$345.35
Details
HOST_Human Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Human His tag   0.05 mg Log in to see 2 to 3 Days
$584.38
Details

CNDP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , ,
Mouse (Murine) ,

Top referenced Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) Proteins

  1. Human CNDP1 Protein expressed in HEK-293 Cells - ABIN2180890 : Lenney, George, Weiss, Kucera, Chan, Rinzler: Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium. in Clinica chimica acta; international journal of clinical chemistry 1982 (PubMed)
    Show all 4 references for 2180890

  2. Human CNDP1 Protein expressed in Human Cells - ABIN2002023 : Riedl, Koeppel, Brinkkoetter, Sternik, Steinbeisser, Sauerhoefer, Janssen, van der Woude, Yard: A CTG polymorphism in the CNDP1 gene determines the secretion of serum carnosinase in Cos-7 transfected cells. in Diabetes 2007 (PubMed)
    Show all 3 references for 2002023

  3. Mouse (Murine) CNDP1 Protein expressed in Human Cells - ABIN2008450 : Sauerhöfer, Yuan, Braun, Deinzer, Neumaier, Gretz, Floege, Kriz, van der Woude, Moeller: L-carnosine, a substrate of carnosinase-1, influences glucose metabolism. in Diabetes 2007 (PubMed)
    Show all 3 references for 2008450

More Proteins for Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) Interaction Partners

Human Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) interaction partners

  1. Considering that approximately 40 per cent of the population are homozygous for the 5L allele of (CTG) n repeat polymorphism in CNDP1 gene and seem to be less prone to develop DN, it is needed to evaluate whether the majority of diabetic patients (who do not have the 5L-5L genotype) would be benefited from supplementation with carnosine or with a more intensive monitoring

  2. Compared to healthy individuals and those with diabetes but no kidney disease, patients with diabetic nephropathy exhibited lower frequencies of 5L-5L genotype and 5L allele of CNDP1 gene, suggesting that this allele might confer protection against development of kidney disease in this population.

  3. genetic association studies in pediatric population in Germany: Data suggest that, in pediatric patients with chronic kidney disease, the nephroprotective effect of CNDP1 Mannheim genetic variant against disease progression is not restricted to patients with diabetic nephropathy.

  4. The experimentally measured higher affinity of homocarnosine for the enzyme relative to l-carnosine might be explained, at least in part, by more extensive interactions inside the monomeric and dimeric hCN1 (show HCN1 Proteins)'s active site.

  5. CNDP1 and CARNS are expressed in glomeruli and tubular cells; TauT (show TAUT Proteins) is expressed in renal epithelial cells; CDNP1 may have a role in diabetic neuropathy

  6. Data shows that higher carnosine content in human skeletal muscle is positively associated with insulin (show INS Proteins) resistance and fasting metabolic preference for glucose.

  7. In gastrointestinal cancer, reduced plasma levels of CNDP1 associate with signs of catabolism and poor outcome.

  8. Alterations of serum carnosinase (CN1) activity has been associated with several pathological conditions, such as neurological disorders, chronic diseases and cancer

  9. Rs12604675-A in CNDP1 may confer susceptibility to overt proteinuria in Japanese women with type 2 diabetes.

  10. In this review, correlations between serum carnosine and carnosinase activity and polymorphism in CNDP1 gene are analyzed. The role of CNDP1 gene polymorphism the development of diabetic nephropathy and non-diabetic chronic kidney disease is discussed.

Carnosine Dipeptidase 1 (Metallopeptidase M20 Family) (CNDP1) Protein Profile

Protein Summary

This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region.

Gene names and symbols associated with CNDP1

  • carnosine dipeptidase 1 (metallopeptidase M20 family) (cndp1)
  • carnosine dipeptidase 1 (metallopeptidase M20 family) (CNDP1)
  • carnosine dipeptidase 1 (metallopeptidase M20 family) (Cndp1)
  • AI746433 protein
  • Cn1 protein
  • CNDP1 protein
  • CPGL2 protein
  • HsT2308 protein

Protein level used designations for CNDP1

carnosine dipeptidase 1 (metallopeptidase M20 family) , beta-Ala-His dipeptidase , CNDP dipeptidase 1 , carnosinase 1 , glutamate carboxypeptidase-like protein 2 , serum carnosinase

GENE ID SPECIES
398917 Xenopus laevis
421012 Gallus gallus
476165 Canis lupus familiaris
614200 Bos taurus
695195 Macaca mulatta
100061728 Equus caballus
100135225 Xenopus (Silurana) tropicalis
100172721 Pongo abelii
100554161 Anolis carolinensis
100583488 Nomascus leucogenys
84735 Homo sapiens
338403 Mus musculus
307212 Rattus norvegicus
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