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Cartilage Oligomeric Matrix Protein Proteins (COMP)

The protein encoded by COMP is a noncollagenous extracellular matrix (ECM) protein. Additionally we are shipping COMP Antibodies (120) and COMP Kits (63) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COMP 25304 P35444
COMP 1311 P49747
COMP 12845 Q9R0G6
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Top COMP Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_HEK-293 Human His tag 50 μg Log in to see 2 to 3 Days
$630.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$732.60
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$777.70
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,150.67
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details
Rat Un-conjugated   100 μg Log in to see 4 to 5 Days
$569.25
Details

COMP Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) ,

Human , , , , ,

Mouse (Murine)

Top referenced COMP Proteins

  1. Human COMP Protein expressed in Human Cells - ABIN2002240 : Newton, Weremowicz, Morton, Copeland, Gilbert, Jenkins, Lawler: Characterization of human and mouse cartilage oligomeric matrix protein. in Genomics 1995 (PubMed)
    Show all 5 references for ABIN2002240

  2. Human COMP Protein expressed in HEK-293 Cells - ABIN2180897 : Chen, Thomas, Hecht, Goldring, Lawler: Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN2180897

  3. Rat (Rattus) COMP Protein expressed in - ABIN1047991 : Spitznagel, Nitsche, Paulsson, Maurer, Zaucke: Characterization of a pseudoachondroplasia-associated mutation (His587-->Arg) in the C-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP). in The Biochemical journal 2004 (PubMed)

More Proteins for Cartilage Oligomeric Matrix Protein (COMP) Interaction Partners

Horse (Equine) Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. The aims of this study were to investigate the proteomic composition of injured tendons during early and late disease stages to identify disease-specific cleavage patterns of the extracellular matrix protein cartilage oligomeric matrix protein (COMP).

  2. The present results suggest that not only type III collagen (show COL3A1 Proteins) but also cartilage oligomeric matrix protein is involved in the repair and remodeling processes of the digital flexor tendon.

  3. Within the limitations of the study design, production of COMP during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 (show TGFB1 Proteins) concentrations.

  4. COMP concentrations in digital flexor tendon sheath synovial fluid were significantly greater than those in normal horses with noninfected tenosynovitis caused by intrathecal tendon/ligament tearing, but not by other lesions.

  5. The present study indicates that dynamic in vivo compression at high load and frequency lowers matrix content of COMP in the articular cartilage of the third carpal bone.

Human Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. The expression of COMP in circulation reflects the severity of rheumatoid arthritis.

  2. findings suggest that Cartilage oligomeric matrix protein (COMP) is associated with the stage of liver fibrosis in chronic hepatitis C

  3. The GG genotype of Med23 (show MED23 Proteins) gene associate with Cognitive Decline and Dementia.

  4. COMP does not directly modify the expression of genes involved in cartilage homeostasis in contrast to several other cartilage matrix proteins.

  5. Overexpression of COMP inhibits BMP-2 (show BMP2 Proteins)-induced osteogenic differentiation and promotes BMP-2 (show BMP2 Proteins)-induced chondrogenic differentiation.

  6. Real-time polymerase chain reaction (RT-PCR) assay presented significantly higher (p<0.01) COMP expression of mesenchymal stem cells cultured with HA/COMP multilayered films.

  7. Mutations in specific residues and/or regions of the type III repeats of COMP are significantly associated with either Pseudoachondroplasia or multiple epiphyseal dysplasia.

  8. Serum COMP was not acutely influenced by experimental anterior knee pain during running.

  9. Novel cartilage oligomeric matrix protein (COMP) neoepitopes identified in synovial fluids from patients with joint diseases using affinity chromatography and mass spectrometry.

  10. Variants within the cartilage oligomeric matrix protein (COMP) gene are not associated with Achilles tendinopathy

Mouse (Murine) Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. COMP-Ang1 (show ANGPT1 Proteins) can enhance BMP2 (show BMP2 Proteins)-induced cranial bone regeneration with increased pericyte recruitment. Combined delivery of the proteins might be a therapeutic strategy to repair cranial bone damage.

  2. COMP deficiency shortened tail-bleeding and clotting time and accelerated ferric-chloride-induced thrombosis. COMP specifically inhibited thrombin-induced platelet aggregation, activation, and retraction and the thrombin-mediated cleavage of fibrinogen.

  3. COMP immunoreactivity was observed in about half of the investigated plaques from the ApoE (show APOE Proteins) null mice, mainly located along the intima-medial border. Plaques in the brachiocephalic artery from ApoE (show APOE Proteins) mice lacking COMP were increased in size with 54%.

  4. study will facilitate better awareness of the differential diagnoses that might be associated with the PSACH/MED spectrum and subsequent care of PSACH/MED patients

  5. The lack of arthritis, together with high levels of COMP-specific antibodies, in COMP-deficient mice indicates that susceptibility to arthritis is COMP specific and that endogenous expression of COMP in wild-type mice tolerizes B cells in vivo.

  6. results imply that COMP is not a key upstream mediator of the anabolic effects of ML on the skeleton.

  7. Lack of COMP and matrilin 3 (show MATN3 Proteins) leads to increased deposition of TIMP-3 (show TIMP3 Proteins), which causes partial inactivation of matrix metalloproteinases in bone, including MMP-13 (show MMP13 Proteins).

  8. A novel form of chondrocyte stress triggered by the expression of a human-like mutation in COMP is central to the pathogenesis of pseudoachondroplasia.

  9. reducing steady state levels of COMP mRNA alleviates intracellular retention of other extracellular matrix proteins associated with the pseudoachondroplasia cellular pathology

  10. Data show that cartilage oligomeric matrix protein (COMP) promotes cell attachment via independent mechanisms involving cell surface CD47 (show CD47 Proteins) and alphaVbeta3 integrin and that cell attachment to COMP induces formation of fascin (show FSCN1 Proteins)-stabilized actin microspikes.

Cow (Bovine) Cartilage Oligomeric Matrix Protein (COMP) interaction partners

  1. COMP synthesis is differentially regulated by TGFbeta1 (show TGFB1 Proteins) in the surface and middle zones of bovine articular cartilage.

  2. role for proteinases other than MMPs in the degradation of COMP in cartilage

  3. COMP mutant expression in tendon fibroblasts leads to increased apoptotic cell death irrespective of the secretory characteristics of mutant COMP

  4. COMP mRNA expression level was markedly increased by ball oscillation.

  5. COMP acts as a catalyst in collagen fibrillogenesis.

COMP Protein Profile

Protein Summary

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

Gene names and symbols associated with COMP

  • cartilage oligomeric matrix protein (COMP)
  • cartilage oligomeric matrix protein (sce3551)
  • cartilage oligomeric matrix protein (CJA_1292)
  • cartilage oligomeric matrix protein (Comp)
  • COMP protein
  • EDM1 protein
  • EPD1 protein
  • MED protein
  • PSACH protein
  • THBS5 protein
  • TSP5 protein

Protein level used designations for COMP

cartilage oligomeric matrix protein , TSP5 , cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , pseudoachondroplasia (epiphyseal dysplasia 1, multiple) , thrombospondin-5 , putative cartilage oligomeric matrix protein

GENE ID SPECIES
469068 Pan troglodytes
5808591 Sorangium cellulosum So ce56
6415089 Cellvibrio japonicus Ueda107
100033911 Equus caballus
25304 Rattus norvegicus
1311 Homo sapiens
12845 Mus musculus
281088 Bos taurus
100720040 Cavia porcellus
396554 Sus scrofa
476665 Canis lupus familiaris
420120 Gallus gallus
101107864 Ovis aries
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