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CBLL1 encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. Additionally we are shipping Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 Proteins (5) and Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 Kits (3) and many more products for this protein.
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Cow (Bovine) Polyclonal CBLL1 Primary Antibody for WB - ABIN2781231
Frame: Newest findings on the oldest oncogene; how activated src does it. in Journal of cell science 2004
Show all 2 Pubmed References
Results suggest that Hakai is an important regulator of cell proliferation and that Hakai may be an oncoprotein and a potential molecular target for cancer treatment.
E-cadherin (show CDH1 Antibodies) distribution and expression is altered in utricle epithelia with induction of apoptosis.
These results suggest that stabilization of delta-catenin (show CTNND2 Antibodies) by Hakai is dependent on Src (show SRC Antibodies).
these observations suggest that the dimeric architecture of the HYB domain is essential for the phosphotyrosine-binding property of Hakai.
By lowering Hakai abundance, miR (show MLXIP Antibodies)-203 also reduces Hakai-regulated-cell division.
Hakai dimerization allows the formation of a phosphotyrosine-binding pocket that recognizes specific phosphorylated tyrosines and flanking acidic amino acids of Src (show SRC Antibodies) substrates, such as E-cadherin (show CDH1 Antibodies), cortactin (show CTTN Antibodies) and DOK1 (show DOK1 Antibodies).
Hakai mediates E-cadherin (show CDH1 Antibodies) ubiquitination and degradation triggered by Slit-Robo signaling during colorectal epithelial cell carcinogenesis.
Together, these data do not support a requirement for CBLL1 during flavivirus entry and rather suggest an essential role of the ubiquitin/proteasome pathway for flavivirus genome amplification.
Results suggest that Hakai is a novel corepressor of ERalpha (show ESR1 Antibodies) and may play a negative role in the development and progression of breast cancers.
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant.
E3 ubiquitin-protein ligase Hakai
, Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
, E3 ubiquitin-protein ligase Hakai-like
, e3 ubiquitin-protein ligase Hakai-like
, E-cadherin binding protein E7
, c-Cbl-like protein 1
, casitas B-lineage lymphoma-transforming sequence-like protein 1
, Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1
, RING finger protein 188
, Casitas B-lineage lymphoma-like 1