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Centromere Protein A Proteins (CENPA)

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. Additionally we are shipping CENPA Antibodies (126) and CENPA Kits (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CENPA 1058 P49450
CENPA 12615 O35216
Rat CENPA CENPA 298850  
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Top CENPA Proteins at

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
Yeast Mouse His tag 50 μg Log in to see 31 to 36 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Cricetulus griseus His tag   1 mg Log in to see 56 to 66 Days
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days

CENPA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine) , ,

More Proteins for Centromere Protein A (CENPA) Interaction Partners

Fruit Fly (Drosophila melanogaster) Centromere Protein A (CENPA) interaction partners

  1. centromere assembly factors CAL1 (show CALCA Proteins) and CENP-C are required for meiotic chromosome segregation, CENP-A assembly and maintenance on sperm, as well as fertility

  2. identify two co-evolving regions, CENP-A L1 and the CAL1 (show CALCA Proteins) N terminus, as critical for lineage-specific CENP-A incorporation

  3. A novel role has been described for the histone acetyltransferase Hat1 (show HAT1 Proteins) in the CENP-A/CID assembly pathway in Drosophila melanogaster.

  4. CENP-A assembly by its loading factor, CAL1, requires RNAPII-mediated transcription of the underlying DNA

  5. The amount of Cid that is loaded during each cell cycle appears to be determined primarily by the preexisting centromeric Cid, with little flexibility for compensation of accidental losses.

  6. CID nucleosomes are octameric in vivo and that CID dimerization is essential for correct centromere assembly.

  7. The F box protein (show FBXO30 Proteins) partner of paired (Ppa (show FBXL14 Proteins)) mediates CenH3(CID) stability in Drosophila. Ppa (show FBXL14 Proteins) depletion results in increased CenH3(CID) levels. Ppa (show FBXL14 Proteins) physically interacts with CenH3(CID) through the CATD (show CTSD Proteins)(CID) that mediates Ppa (show FBXL14 Proteins)-dependent CenH3(CID) stability.

  8. Drosophila CENP-C is essential for centromere identity.

  9. Cid allows for contacts betwen DNA and histones and specific targeting

  10. Results suggest that CID mislocalization promotes formation of ectopic centromeres and multicentric chromosomes, which causes chromosome missegregation, aneuploidy, and growth defects.

Human Centromere Protein A (CENPA) interaction partners

  1. CENP-C and CENP-I (show CENPI Proteins) are key factors connecting kinetochore to CENP-A assembly.

  2. The authors found that the nucleosome shape change directed by CENP-A is dominated by lateral passing of two DNA gyres (gyre sliding).

  3. the CRL4 complex containing RBBP7 (show RBBP7 Proteins) (CRL4(RBBP7 (show RBBP7 Proteins))) might regulate mitosis by promoting ubiquitin-dependent loading of newly synthesized CENP-A during the G1 phase of the cell cycle.

  4. The DNA ends of the CENP-A nucleosome are more flexible than those of the H3 nucleosome.

  5. We used a synthetic system to dissect how CenH3(CENP-A) contributes to the accumulation of CENP-C and CENP-T (show CENPT Proteins), two key components that are necessary for the formation of functional kinetochores

  6. The CENP-A/histone H3.3 (show H3F3A Proteins) nucleosome forms an unexpectedly stable structure and allows the binding of the essential centromeric protein, CENP-C, which is ectopically mislocalized in the chromosomes of CENP-A overexpressing tumor cells.

  7. CENP-B directly binds both CENP-A's amino-terminal tail and CENP-C, a key nucleator of kinetochore assembly

  8. CENP-C depletion leads to rapid removal of CENP-A from centromeres, indicating their collaboration in maintaining centromere identity.

  9. The study describes a novel function for human centromeric long non-coding RNAs in the recruitment of HJURP (show HJURP Proteins) and CENP-A, implicating RNA-based chaperone targeting in histone variant assembly.

  10. results indicate that the regions of CENP-A required for early events in centromere establishment differ from those that are required for maintaining centromere identity.

Mouse (Murine) Centromere Protein A (CENPA) interaction partners

  1. CPCs maintain relatively high levels of CENP-A early in life, which is necessary for sustaining proliferation, inhibiting senescence, and promoting survival following differentiation of CPCs.

  2. Results report that the level of CENP-A, a protein required for cell division, declines precipitously with age in an islet-specific manner.

  3. Cenpa, Cenpb (show CENPB Proteins), and Bub3 (show BUB3 Proteins), but not Cenpc, interacted with PARP-1 (show PARP1 Proteins)

  4. The centromere-targeting domain of CENP-A is both necessary and sufficient for recruitment to double-strand breaks. CENP-A accumulation at DNA breaks is enhanced by active non-homologous end-joining but does not require DNA-PKcs (show PRKDC Proteins) or Ligase IV.

Xenopus laevis Centromere Protein A (CENPA) interaction partners

  1. CENP-A assembly into chromatin requires unidentified deoxycytidine deaminase (show APOBEC3G Proteins) and UNG2 (show CCNO Proteins), a uracil DNA glycosylase (show UNG Proteins).

  2. CENP-A deposition at the centromeres is dependent on HJURP (show HJURP Proteins).

CENPA Protein Profile

Protein Summary

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with Centromere Protein A Proteins (CENPA)

  • centromere identifier (cid)
  • centromere protein-A (CENP-A)
  • centromere protein A (cenpa)
  • centromeric histone-3 like protein (cenp-A)
  • centromere-specific histone H3 CENP-A (cnp1)
  • cenp-A (HAN_3g422)
  • centromere protein A (Cenp-a)
  • centromere protein A (CENPA)
  • centromere protein A (CMU_016480)
  • centromere protein A (Cenpa)
  • centromere protein A-like (LOC100353660)
  • histone H3-like centromeric protein A (cenpa)
  • BcDNA:RE21270 protein
  • cenH3 protein
  • CenH3/CID protein
  • CenH3[Cid] protein
  • Cenp-a protein
  • CENP-A/Cid protein
  • CENP-C protein
  • cenpA protein
  • CenpA/CID protein
  • cenpx protein
  • CG13329 protein
  • Cid protein
  • CID/CENP-A protein
  • Cid[Mel] protein
  • Dmel\\CG13329 protein
  • RGD1563607 protein
  • sim2 protein

Protein level used designations for Centromere Protein A Proteins (CENPA)

CG13329-PA , centromere identifier protein , centromere protein A , cid-PA , centromere protein-A , centromere protein, Xenopus , histone H3-like centromeric protein A , centromeric histone-3 like protein , cenp-A , centromere autoantigen A , centromere protein A, 17kDa , centromere-specific histone , centrosomin A , CENP-A , ggCENP-A

36495 Drosophila melanogaster
407119 Bos taurus
549339 Xenopus (Silurana) tropicalis
857118 Guillardia theta
2539658 Schizosaccharomyces pombe 972h-
5739547 Hemiselmis andersenii
100233153 Nasonia vitripennis
459086 Pan troglodytes
697312 Macaca mulatta
6995376 Cryptosporidium muris RN66
613898 Bos taurus
1058 Homo sapiens
12615 Mus musculus
298850 Rattus norvegicus
475692 Canis lupus familiaris
100724949 Cavia porcellus
100113359 Gallus gallus
101110750 Ovis aries
735079 Xenopus laevis
100689459 Cricetulus griseus
100353660 Oryctolagus cuniculus
100302659 Danio rerio
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