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Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase Proteins (CHFR)

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Additionally we are shipping Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase Antibodies (65) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHFR 231600 Q810L3
CHFR 55743 Q96EP1
Rat CHFR CHFR 288734  
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Top Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

CHFR Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase (CHFR) Interaction Partners

Mouse (Murine) Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase (CHFR) interaction partners

  1. CHFR is important for the survival of male premeiotic germ cells, which is likely through maintaining genomic stability in spermatogonial stem cells.

  2. The interaction between CHFR and PARP-1 (show PARP1 Proteins) plays an important role in cell cycle regulation and cancer therapeutic strategies.

  3. CHFR interacts with BRG1, SNF5, and BAF60a of the SWI/SNF-like BAF complex and ubiquitinates them to target for degradation through a proteasome-mediated pathway; SRG3 stabilizes these components by blocking their interaction with CHFR.

  4. RNF8 (show RNF8 Proteins) and Chfr, function together to activate ATM (show ATM Proteins) and maintain genomic stability in vivo.

  5. Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.

  6. PML bodies control the distribution, dynamics and function of CHFR

  7. Downregulation of Chfr contributes to tumorigenesis by controlling the expression levels of Aurora A (show AURKA Proteins).

  8. Mice with deficiencies in both Chfr and Mlh1 (show MLH1 Proteins) (the gene that encodes the DNA mismatch-repair protein Mlh1 (show MLH1 Proteins)) displayed dramatically higher incidence of spontaneous tumors relative to mice deficient for only one of these genes.

Human Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase (CHFR) interaction partners

  1. Data show that hypermethylation of the CHFR promoter, frequent in acute myeloid leukemia (show BCL11A Proteins), is associated with adverse outcome, and can thus be used for risk stratification.

  2. Small molecule inhibition of CHFR-PARP1 (show PARP1 Proteins) interaction is a novel potential therapeutic approach to increase the efficacy of taxane-based chemotherapy in cancer.

  3. CHFR unmethylation is associated with oxaliplatin resistance in gastric cancer.

  4. CHFR methylation has a role in methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer

  5. CHFR promoter methylation is associated with colorectal cancer.

  6. CHFR-PAX5 (show PAX5 Proteins) fusion transcript is associated with B-cell precursor acute lymphoblastic leukemia.

  7. Aberrant methylation of CHFR may be associated with the pathogenesis, progression for B-cell non-Hodgkin lymphoma(B-NHL), which might be a novel molecular marker as prognosis and treatment for B-NHL.

  8. Studies indicate that checkpoint with forkhead and ring finger domains (CHFR) promoter CpG island methylation as prognostic marker.

  9. CHFR ubiquitinates and regulates TOPK (show PBK Proteins) levels, which is essential for its checkpoint function.

  10. CHFR methylation may have a role in chemosensitivity of paclitaxel in advanced gastric cancer

Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase (CHFR) Protein Profile

Protein Summary

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).

Gene names and symbols associated with CHFR

  • checkpoint with forkhead and ring finger domains (Chfr)
  • checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (CHFR)
  • checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (Chfr)
  • checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (chfr)
  • 5730484M20Rik protein
  • C230082M18 protein
  • fc43f10 protein
  • RNF116 protein
  • RNF196 protein
  • si:dkey-69h6.7 protein
  • wu:fc43f10 protein

Protein level used designations for CHFR

E3 ubiquitin-protein ligase CHFR , checkpoint with forkhead and RING finger domains protein , RING finger protein 196 , Checkpoint with forkhead and RING finger domains protein

GENE ID SPECIES
231600 Mus musculus
55743 Homo sapiens
100154400 Sus scrofa
614816 Bos taurus
288734 Rattus norvegicus
564271 Danio rerio
734287 Xenopus laevis
477434 Canis lupus familiaris
100171543 Pongo abelii
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