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E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Additionally we are shipping Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase Antibodies (69) and many more products for this protein.
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CHFR is important for the survival of male premeiotic germ cells, which is likely through maintaining genomic stability in spermatogonial stem cells.
The interaction between CHFR and PARP-1 (show PARP1 Proteins) plays an important role in cell cycle regulation and cancer therapeutic strategies.
CHFR interacts with BRG1, SNF5, and BAF60a of the SWI/SNF-like BAF complex and ubiquitinates them to target for degradation through a proteasome-mediated pathway; SRG3 stabilizes these components by blocking their interaction with CHFR.
RNF8 (show RNF8 Proteins) and Chfr, function together to activate ATM (show ATM Proteins) and maintain genomic stability in vivo.
Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.
PML bodies control the distribution, dynamics and function of CHFR
Downregulation of Chfr contributes to tumorigenesis by controlling the expression levels of Aurora A (show AURKA Proteins).
Mice with deficiencies in both Chfr and Mlh1 (show MLH1 Proteins) (the gene that encodes the DNA mismatch-repair protein Mlh1 (show MLH1 Proteins)) displayed dramatically higher incidence of spontaneous tumors relative to mice deficient for only one of these genes.
Re-expression of CHFR in miR (show MLXIP Proteins)-26a overexpressing cells partially rescues normal mitosis and impairs the tumorigenesis exerted by miR (show MLXIP Proteins)-26a.
Data show that hypermethylation of the CHFR promoter, frequent in acute myeloid leukemia (show BCL11A Proteins), is associated with adverse outcome, and can thus be used for risk stratification.
Small molecule inhibition of CHFR-PARP1 (show PARP1 Proteins) interaction is a novel potential therapeutic approach to increase the efficacy of taxane-based chemotherapy in cancer.
CHFR unmethylation is associated with oxaliplatin resistance in gastric cancer.
CHFR methylation has a role in methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer
CHFR promoter methylation is associated with colorectal cancer.
CHFR-PAX5 (show PAX5 Proteins) fusion transcript is associated with B-cell precursor acute lymphoblastic leukemia.
Aberrant methylation of CHFR may be associated with the pathogenesis, progression for B-cell non-Hodgkin lymphoma(B-NHL), which might be a novel molecular marker as prognosis and treatment for B-NHL.
Studies indicate that checkpoint with forkhead and ring finger domains (CHFR) promoter CpG island methylation as prognostic marker.
CHFR ubiquitinates and regulates TOPK (show PBK Proteins) levels, which is essential for its checkpoint function.
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).
E3 ubiquitin-protein ligase CHFR
, checkpoint with forkhead and RING finger domains protein
, RING finger protein 196
, Checkpoint with forkhead and RING finger domains protein