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Chloride Channel 4 Proteins (CLCN4)

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Additionally we are shipping Chloride Channel 4 Antibodies (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLCN4 12727 Q61418
CLCN4 1183 P51793
Rat CLCN4 CLCN4 60586  
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Top Chloride Channel 4 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details

CLCN4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human ,
,

More Proteins for Chloride Channel 4 (CLCN4) Interaction Partners

Mouse (Murine) Chloride Channel 4 (CLCN4) interaction partners

  1. In Mus (show TRPV6 Proteins) spretus, the chloride channel 4 gene Clcn4-2 is X-linked and dosage compensated by X up-regulation and X inactivation, while in the closely related mouse species Mus (show TRPV6 Proteins) musculus, Clcn4-2 has been translocated to chromosome 7.

Human Chloride Channel 4 (CLCN4) interaction partners

  1. This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5 (show KCNH5 Proteins), CLCN4, and ARHGEF15 (show ARHGEF15 Proteins)) not previously associated with epilepsies in humans.

  2. the voltage dependence of uncoupled ClC-4 by protons and anions

  3. CLCN4 is a novel driver of colon cancer progression.

  4. Studies showed that three novel CLC-5 (show CLCN5 Proteins) mutations were identified, and mutations in OCRL1 (show OCRL Proteins), CLC-4 and cofilin (show CFL1 Proteins) excluded in causing Dent's disease.

  5. ClC-4 is an intracellular chloride channel (show CLCA1 Proteins) that stimulates copper incorporation into ceruloplasmin (show CP Proteins), probably by improving the efficiency of the ATP7B (show ATP7B Proteins) copper pump.

  6. coupled Cl-/H+ transport of ClC-4 and ClC-5 (show CLCN5 Proteins) is of significant magnitude in vivo

  7. crystal structure: CLIC4 (show CLIC4 Proteins) appears to be able to form a redox-regulated ion channel in the absence of any partner proteins

  8. The proposed mechanism results in anion-dependent conversion of ClC (show CLC Proteins)-type exchanger into an anion channel with typical attributes of ClC (show CLC Proteins) anion channels.

Chloride Channel 4 (CLCN4) Protein Profile

Protein Summary

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins.

Gene names and symbols associated with Chloride Channel 4 Proteins (CLCN4)

  • chloride channel 4 (CLCN4)
  • chloride channel, voltage-sensitive 4 (CLCN4)
  • chloride channel, voltage-sensitive 4 (clcn4)
  • chloride channel 4-2 (Clcn4-2)
  • chloride channel, voltage-sensitive 4 (Clcn4)
  • ClC-4 protein
  • ClC-4A protein
  • CLC4 protein
  • Clc4-2 protein
  • Clcn4 protein
  • Clcn4-2 protein

Protein level used designations for Chloride Channel 4 Proteins (CLCN4)

chloride channel 4 , H(+)/Cl(-) exchange transporter 4 , chloride channel protein 4 , chloride transporter ClC-4 , clC-4 , voltage-gated chloride channel ClC-4A , chloride channel 4-2 , putative chloride channel (similar to Mm Clcn4-2) , putative chloride channel 4-2

GENE ID SPECIES
428005 Gallus gallus
491736 Canis lupus familiaris
511699 Bos taurus
100145074 Xenopus (Silurana) tropicalis
12727 Mus musculus
1183 Homo sapiens
60586 Rattus norvegicus
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