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Chloride Channel Ka Proteins (CLCNKA)

CLCNKA is a member of the CLC family of voltage-gated chloride channels. Additionally we are shipping Chloride Channel Ka Antibodies (45) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLCNKA 12733 Q9WUB7
CLCNKA 1187 P51800
Rat CLCNKA CLCNKA 79425 Q06393
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Top Chloride Channel Ka Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details

CLCNKA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human ,
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More Proteins for Chloride Channel Ka (CLCNKA) Interaction Partners

Mouse (Murine) Chloride Channel Ka (CLCNKA) interaction partners

  1. molecular substrate of a chloride channel (show CLCA1 Proteins) previously detected in the mouse thick ascending limb

  2. the major component of Cl(-) transport sensitive to NPPB (show BNP Proteins) or pH is mediated by CLC-K1 in the tAL (show TALDO1 Proteins).

  3. Gene expression profiling in the collecting tubules of aquaporin-1 (show AQP1 Proteins) and CLC (show CLC Proteins)-Nk1 (show HGF Proteins) knockout mice.

  4. induction of SGK1 (show SGK1 Proteins), CLC-K1 and barttin (show BSND Proteins) by high osmolarity and change in intracellular volume in distal renal tubular cells in vivo and in vitro

Human Chloride Channel Ka (CLCNKA) interaction partners

  1. Single loci of tag Single Nucleotide Polymorphisms of CLCNKA_B are not enough to increase the Essential Hypertension susceptibility, the combination of CLCNKA SNP, salt, marine products, meat, edible oil consumption is associated with elevated risk.

  2. R8W and G47R, two naturally occurring barttin (show BSND Proteins) mutations identified in patients with Bartter syndrome type IV, reduce barttin (show BSND Proteins) palmitoylation and CLC-K (show CLCNKB Proteins)/barttin (show BSND Proteins) channel activity.

  3. HEK293 cells the potentiating effect of niflumic acid (NFA) on CLC-Ka (show CLCNKB Proteins)/barttin (show BSND Proteins) and CLC-Kb (show CLCNKB Proteins)/barttin (show BSND Proteins) channels seems to be absent while the blocking efficacy of niflumic acid and benzofuran derivatives observed in oocytes is preserved

  4. following variables were significantly associated with an estimated glomerular filtration rate: age, type 2 diabetes, total cholesterol, LDL-cholesterol, and the CLCNKA GG genotype

  5. The variant CLCNKA risk allele, telegraphed by linked variants in the adjacent HSPB7 (show HSPB7 Proteins) gene, uncovers a previously overlooked genetic mechanism affecting the cardio-renal axis.

  6. Identify a protein region that is involved in calcium binding and that is likely undergoing conformational changes underlying the complex gating of CLC-K (show CLCNKB Proteins) channels.

  7. Combined impairment of ClC-Ka (show CLCNKB Proteins) and ClC-Kb (show CLCNKB Proteins) results in phenotype that mimics neonatal Barrter's syndrome with deafness

  8. Barttin (show BSND Proteins) modulates trafficking and function of ClC-K1 and ClC-Kb (show CLCNKB Proteins) channels

  9. CLCNKA genetic variants may have roles in salt-sensitive hypertension

  10. The structure of the cytoplasmic domain of CLCNKA reveals a conserved interaction interface.

Chloride Channel Ka (CLCNKA) Protein Profile

Protein Summary

This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Chloride Channel Ka Proteins (CLCNKA)

  • chloride channel Ka (CLCNKA)
  • chloride channel Ka (Clcnka)
  • chloride channel, voltage-sensitive Ka (CLCNKA)
  • chloride channel, voltage-sensitive Ka (Clcnka)
  • C75963 protein
  • ClC-K1 protein
  • CLCK1 protein
  • Clcnk1 protein
  • CLCNKA protein
  • CLCNKB protein
  • hClC-Ka protein

Protein level used designations for Chloride Channel Ka Proteins (CLCNKA)

chloride channel Ka , chloride channel protein ClC-Ka-like , chloride channel K1 , chloride channel protein ClC-Ka , putative basolateral cTAL chloride channel ClC-Ka , chloride channel, kidney, A , clC-K1 , Chloride channel protein ClC-Kb , chloride channel Kb , clC-K2

GENE ID SPECIES
469844 Pan troglodytes
703259 Macaca mulatta
100456543 Pongo abelii
100593875 Nomascus leucogenys
12733 Mus musculus
1187 Homo sapiens
79425 Rattus norvegicus
100009213 Oryctolagus cuniculus
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