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The protein encoded by CSPG5 is a proteoglycan that may function as a neural growth and differentiation factor. Additionally we are shipping CSPG5 Antibodies (65) and CSPG5 Kits (7) and many more products for this protein.
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CALEB is transiently required for synapse maturation in the cerebellum.
Despite the previously reported upregulation of Cspg5 during retinal degeneration in Rpe65 (show RPE65 Proteins)/ mice, no protective effect or any involvement of Cspg5 in disease progression was identified.
there is a glycosylation site for chondroitin sulfate on the neural part-time proteoglycan (show Vcan Proteins), neuroglycan C
neuroglycan C is a novel component of midkine (show MDK Proteins) receptors involved in process elongation
PI3K-Akt (show AKT1 Proteins)-mammalian target of rapamycin (mTOR (show FRAP1 Proteins)) signaling pathway and PKC are important for CALEB/NGC-induced stimulation of dendritic branching. CALEB/NGC-induced spine morphogenesis is independent of PI3K but depends on PKC.
During retinal degeneration in Rpe65 (show RPE65 Proteins)-/- mice, neuroglycan C(NGC) expression is induced in neural retina, but not in retinal pigment epithelium, where NGC is expressed at highest levels.
results suggest that NGC may be a novel candidate gene, and neuregulin signaling pathways may play an important role in schizophrenia
NGC IV, which was first found in the present study, had the shortest cytoplasmic domain among the four variants
The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene.
chondroitin sulfate proteoglycan 5 (neuroglycan C)
, chondroitin sulfate proteoglycan 5
, acidic leucine-rich EGF-like domain-containing brain protein
, neuroglycan C
, epidermal growth factor