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anti-Chromodomain Helicase DNA Binding Protein 4 (CHD4) Antibodies

The product of CHD4 belongs to the SNF2/RAD54 helicase family. Additionally we are shipping CHD4 Kits (7) and CHD4 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CHD4 1108 Q14839
CHD4 117535  
CHD4 107932 Q6PDQ2
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Top anti-CHD4 Antibodies at antibodies-online.com

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CHD4 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: OVCAR-3 cell lysate WB Suggested Anti-CHD4  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500  Positive Control: OVCAR-3 cell lysate  There is BioGPS gene expression data showing that CHD4 is expressed in OVCAR3 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using CHD4 Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using CHD4 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated WB Western Blot analysis of CHD4 expression in transfected 293T cell line by CHD4 monoclonal antibody (M01), clone 4H4. Lane 1: CHD4 transfected lysate(220 KDa). Lane 2: Non-transfected lysate. CHD4 monoclonal antibody (M01), clone 4H4 Western Blot analysis of CHD4 expression in HeLa NE. 0.05 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IP, WB 100 μL Log in to see 8 to 9 Days
$392.86
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to CHD4 on formalin-fixed paraffin-embedded human transitional cell carcinoma. [antibody concentration 3 ug/ml] CHD4 monoclonal antibody (M01), clone 4H4 Western Blot analysis of CHD4 expression in Hela S3 NE . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, WB Mi-2 beta antibody tested by immunofluorescence. Top left: HeLa cells stained with Mi-2 beta antibody (1:1,000). Top right: Same cells stained with alpha Tubulin mAb (Clone 5-B-1-2). Bottom left: Same cells stained with DAPI. Bottom right: Merge of all 3 images. Mi-2 beta antibody tested by Western blot. Whole-cell extract of mouse splenocytes stained with Mi-2 beta antibody (1:1,1000). 200 μL Log in to see 1 to 2 Days
$466.67
Details
Human Rabbit Un-conjugated ICC, IF, IP, WB IP Image Immunoprecipitation of CHD4 protein from 293T whole cell extracts using 5 μg of CHD4 antibody, Western blot analysis was performed using CHD4 antibody, EasyBlot anti-Rabbit IgG  was used as a secondary reagent. WB Image Sample (30 ug of whole cell lysate) A: Jurkat B: Raji C: K562 5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IHC (p), WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$676.50
Details
Fruit Fly Rat Un-conjugated IP, WB   100 μg Log in to see 1 to 2 Days
$466.67
Details
Human Rabbit Un-conjugated IF, ELISA 100 μL Log in to see 8 to 10 Days
$478.50
Details

CHD4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
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Rat (Rattus)


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Top referenced anti-CHD4 Antibodies

  1. Human Monoclonal CHD4 Primary Antibody for WB - ABIN393812 : Li, Zhang, Yu, Chen, Gui, Liang, Wang, Sun, Yang, Zhang, Shi, Li, Shang: ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. in The EMBO journal 2009 (PubMed)
    Show all 5 references for ABIN393812

  2. Human Polyclonal CHD4 Primary Antibody for ICC, IF - ABIN2668534 : Curtis, Griffin: The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. in Molecular and cellular biology 2012 (PubMed)
    Show all 3 references for ABIN2668534

  3. Fruit Fly (Drosophila melanogaster) Monoclonal CHD4 Primary Antibody for IP, WB - ABIN2668526 : Murawska, Kunert, van Vugt, Längst, Kremmer, Logie, Brehm: dCHD3, a novel ATP-dependent chromatin remodeler associated with sites of active transcription. in Molecular and cellular biology 2008 (PubMed)

  4. Cow (Bovine) Polyclonal CHD4 Primary Antibody for WB - ABIN2775753 : Sillibourne, Delaval, Redick, Sinha, Doxsey: Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity. in Molecular biology of the cell 2007 (PubMed)

  5. Human Monoclonal CHD4 Primary Antibody for IHC (p), ELISA - ABIN560357 : Nishibuchi, Shibata, Hayakawa, Hayakawa, Ohtani, Sinmyozu, Tagami, Nakayama: Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex. in The Journal of biological chemistry 2014 (PubMed)

  6. Human Polyclonal CHD4 Primary Antibody for IF, IHC - ABIN1533894 : Schmidt, Schreiber: Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. in Biochemistry 1999 (PubMed)

More Antibodies against CHD4 Interaction Partners

Human Chromodomain Helicase DNA Binding Protein 4 (CHD4) interaction partners

  1. Specifically, methyl-CpG-binding domain protein 2 (MBD2 (show MBD2 Antibodies)) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (show DPEP1 Antibodies) domain and MBD2 (show DPEP2 Antibodies) C-terminus.

  2. these data build on our understanding of how CHD4-NuRD acts to regulate gene expression and participates in the DNA-damage response.

  3. CHD4 depletion modulates expression of acute myeloid leukemia (show BCL11A Antibodies) cell genes that regulate tumor formation in vivo and colony formation in vitro.

  4. Also discovered a novel causative role for CHD4, a helicase involved in the histone deacetylase (show HDAC1 Antibodies) complex that is associated with poor clinical outcome.

  5. CHD4 modulates therapeutic response in BRCA2 (show BRCA2 Antibodies) mutant cancer cells.

  6. Endogenous Mta1 (show MTA1 Antibodies)/2 forms a complex with chromodomain helicase (Chd)4, histone deacetylases (Hdac)1 (show HDAC1 Antibodies)/2, RbAp46 (show RBBP7 Antibodies)/48, and Mbd3 (show MBD3 Antibodies) in rat cerebellum

  7. CHD4 and HDAC1 (show HDAC1 Antibodies) occupy the promoters of several of these hypermethylated tumor suppressor genes and physically and functionally interact to maintain their silencing.

  8. repressive functions of MBD2 (show DPEP2 Antibodies)-containing NuRD complexes are dependent on cooperative interactions between the major domains of CHD4 with histones and DNA and on binding of methylated DNA by MBD2 (show DPEP2 Antibodies)

  9. a three-dimensional structural model describing the overall shape and domain interactions of CHD4 and discuss the relevance of these for regulating the remodeling of chromatin by the NuRD complex.

  10. Concerted action of the PHD (show PDC Antibodies), chromo and motor domains regulates the human chromatin remodelling ATPase (show DNAH8 Antibodies) CHD4

Mouse (Murine) Chromodomain Helicase DNA Binding Protein 4 (CHD4) interaction partners

  1. CHD4 depletion modulates expression of acute myeloid leukemia (show BCL11A Antibodies) cell genes that regulate tumor formation in vivo and colony formation in vitro.

  2. CHD4 allows cells to undertake lineage commitment in vivo by modulating the frequency with which lineage-specification genes are expressed.

  3. Chromatin immunoprecipitation assays showed that CHD4-containing NuRD complexes directly bound the promoters of these genes in endothelial cells

  4. Chd4, interacting with Hdac1 (show HDAC1 Antibodies)/2, cooperates with its related proteins Kap1 (show TRIM28 Antibodies) and Cbx1 (show CBX1 Antibodies) to bind at -207/-148 of the Sox9 (show SOX9 Antibodies) promoter.

  5. NuRD negatively regulates TIP5 (show BAZ2A Antibodies) expression, thereby inhibiting ribosomal DNA (rDNA) methylation and maintaining demethylation state of rDNA promoters.

  6. The chromodomain helicase DNA-binding protein 4 (Chd4) is a critical interaction partner of Ezh2 (show EZH2 Antibodies) required specifically for Polycomb (show CBX2 Antibodies) group (PcG)-mediated suppression of the key astrogenic marker gene GFAP (show GFAP Antibodies).

  7. Gata3 (show GATA3 Antibodies)/Chd4 forms functionally distinct complexes, which mediate both positive and negative gene regulation to facilitate Th2 cell differentiation.

  8. In this study, we demonstrate that Mi2beta is required for gamma-globin gene silencing during adult definitive erythropoiesis

  9. Concomitant deletion of Chd4 and Brg1 rescued vascular abnormalities seen in Brg1 mutant yolk sacs to the same extent as LiCl treatment.

  10. activity of the Mi-2beta nucleosome-remodeling and histone-deacetylase (show HDAC1 Antibodies) (NuRD) complex was controlled by the Ikaros (show IKZF1 Antibodies) family of lymphoid lineage-determining proteins.

Xenopus laevis Chromodomain Helicase DNA Binding Protein 4 (CHD4) interaction partners

  1. CHD4 functions as a MAP required for MT stabilization and is involved in generating spindle bipolarity.

CHD4 Antigen Profile

Protein Summary

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.

Gene names and symbols associated with CHD4

  • chromodomain helicase DNA binding protein 4 (CHD4) antibody
  • chromodomain helicase DNA binding protein 4a (chd4a) antibody
  • chromodomain helicase DNA binding protein 4b (chd4b) antibody
  • chromodomain helicase DNA binding protein 4 (chd4) antibody
  • chromodomain helicase DNA binding protein 4 (Chd4) antibody
  • 9530019N15Rik antibody
  • AA617397 antibody
  • b230399n07 antibody
  • BC005710 antibody
  • CHD4 antibody
  • D6Ertd380e antibody
  • im:7143343 antibody
  • MGC145363 antibody
  • Mi-2 antibody
  • Mi-2b antibody
  • Mi-2beta antibody
  • Mi2-BETA antibody
  • mKIAA4075 antibody
  • si:ch211-51m24.3 antibody
  • si:ch211-57k11.10 antibody
  • wu:fb44b12 antibody
  • wu:fd12d03 antibody

Protein level used designations for CHD4

chromodomain helicase DNA binding protein 4 , chromodomain-helicase-DNA-binding protein 4 , ATP-dependent helicase CHD4 , CHD-4 , Mi-2 autoantigen 218 kDa protein , Mi-2 autoantigen , Mi-2 beta

GENE ID SPECIES
418278 Gallus gallus
451788 Pan troglodytes
558344 Danio rerio
560622 Danio rerio
100059817 Equus caballus
100124711 Xenopus (Silurana) tropicalis
100515610 Sus scrofa
100539798 Meleagris gallopavo
100566510 Anolis carolinensis
1108 Homo sapiens
117535 Rattus norvegicus
107932 Mus musculus
380196 Xenopus laevis
477714 Canis lupus familiaris
506402 Bos taurus
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