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The product of CHD4 belongs to the SNF2/RAD54 helicase family. Additionally we are shipping CHD4 Kits (7) and CHD4 Proteins (6) and many more products for this protein.
Showing 10 out of 76 products:
Human Monoclonal CHD4 Primary Antibody for WB - ABIN393812
Li, Zhang, Yu, Chen, Gui, Liang, Wang, Sun, Yang, Zhang, Shi, Li, Shang: ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. in The EMBO journal 2009
Show all 5 references for ABIN393812
Human Polyclonal CHD4 Primary Antibody for ICC, IF - ABIN2668534
Curtis, Griffin: The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. in Molecular and cellular biology 2012
Show all 3 references for ABIN2668534
Human Polyclonal CHD4 Primary Antibody for IP, PLA - ABIN252858
Ma, Lin, Bartolomei, Schultz: Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. in Biology of reproduction 2010
Human Monoclonal CHD4 Primary Antibody for IHC (p), ELISA - ABIN560357
Nishibuchi, Shibata, Hayakawa, Hayakawa, Ohtani, Sinmyozu, Tagami, Nakayama: Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex. in The Journal of biological chemistry 2014
Human Polyclonal CHD4 Primary Antibody for IP, WB - ABIN252857
Shakya, Kang, Chumley, Williams, Tantin: Oct1 is a switchable, bipotential stabilizer of repressed and inducible transcriptional states. in The Journal of biological chemistry 2011
Human Polyclonal CHD4 Primary Antibody for IF, IHC - ABIN1533894
Schmidt, Schreiber: Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. in Biochemistry 1999
Cow (Bovine) Polyclonal CHD4 Primary Antibody for WB - ABIN2775753
Sillibourne, Delaval, Redick, Sinha, Doxsey: Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity. in Molecular biology of the cell 2007
Human Polyclonal CHD4 Primary Antibody for IP, WB - ABIN252859
Gu, Hu, Ebrahem, Crabb, Mahfouz, Radivoyevitch, Crabb, Saunthararajah: Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy. in The Journal of biological chemistry 2014
Specifically, methyl-CpG-binding domain protein 2 (MBD2 (show MBD2 Antibodies)) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (show DPEP1 Antibodies) domain and MBD2 (show DPEP2 Antibodies) C-terminus.
these data build on our understanding of how CHD4-NuRD acts to regulate gene expression and participates in the DNA-damage response.
CHD4 depletion modulates expression of acute myeloid leukemia (show BCL11A Antibodies) cell genes that regulate tumor formation in vivo and colony formation in vitro.
Also discovered a novel causative role for CHD4, a helicase involved in the histone deacetylase (show HDAC1 Antibodies) complex that is associated with poor clinical outcome.
CHD4 modulates therapeutic response in BRCA2 (show BRCA2 Antibodies) mutant cancer cells.
Endogenous Mta1 (show MTA1 Antibodies)/2 forms a complex with chromodomain helicase (Chd)4, histone deacetylases (Hdac)1 (show HDAC1 Antibodies)/2, RbAp46 (show RBBP7 Antibodies)/48, and Mbd3 (show MBD3 Antibodies) in rat cerebellum
CHD4 and HDAC1 (show HDAC1 Antibodies) occupy the promoters of several of these hypermethylated tumor suppressor genes and physically and functionally interact to maintain their silencing.
repressive functions of MBD2 (show DPEP2 Antibodies)-containing NuRD complexes are dependent on cooperative interactions between the major domains of CHD4 with histones and DNA and on binding of methylated DNA by MBD2 (show DPEP2 Antibodies)
a three-dimensional structural model describing the overall shape and domain interactions of CHD4 and discuss the relevance of these for regulating the remodeling of chromatin by the NuRD complex.
Concerted action of the PHD (show PDC Antibodies), chromo and motor domains regulates the human chromatin remodelling ATPase (show DNAH8 Antibodies) CHD4
CHD4 allows cells to undertake lineage commitment in vivo by modulating the frequency with which lineage-specification genes are expressed.
Chromatin immunoprecipitation assays showed that CHD4-containing NuRD complexes directly bound the promoters of these genes in endothelial cells
Chd4, interacting with Hdac1 (show HDAC1 Antibodies)/2, cooperates with its related proteins Kap1 (show TRIM28 Antibodies) and Cbx1 (show CBX1 Antibodies) to bind at -207/-148 of the Sox9 (show SOX9 Antibodies) promoter.
NuRD negatively regulates TIP5 (show BAZ2A Antibodies) expression, thereby inhibiting ribosomal DNA (rDNA) methylation and maintaining demethylation state of rDNA promoters.
The chromodomain helicase DNA-binding protein 4 (Chd4) is a critical interaction partner of Ezh2 (show EZH2 Antibodies) required specifically for Polycomb (show CBX2 Antibodies) group (PcG)-mediated suppression of the key astrogenic marker gene GFAP (show GFAP Antibodies).
Gata3 (show GATA3 Antibodies)/Chd4 forms functionally distinct complexes, which mediate both positive and negative gene regulation to facilitate Th2 cell differentiation.
In this study, we demonstrate that Mi2beta is required for gamma-globin gene silencing during adult definitive erythropoiesis
Concomitant deletion of Chd4 and Brg1 rescued vascular abnormalities seen in Brg1 mutant yolk sacs to the same extent as LiCl treatment.
activity of the Mi-2beta nucleosome-remodeling and histone-deacetylase (show HDAC1 Antibodies) (NuRD) complex was controlled by the Ikaros (show IKZF1 Antibodies) family of lymphoid lineage-determining proteins.
CHD4 functions as a MAP required for MT stabilization and is involved in generating spindle bipolarity.
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
chromodomain helicase DNA binding protein 4
, chromodomain-helicase-DNA-binding protein 4
, ATP-dependent helicase CHD4
, Mi-2 autoantigen 218 kDa protein
, Mi-2 autoantigen
, Mi-2 beta