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CHGB encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. Additionally we are shipping CHGB Antibodies (51) and CHGB Kits (30) and many more products for this protein.
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This analysis of mice lacking Cgs highlights the important roles of CgA and CgB in glucose and cardiovascular homeostasis. This study also unveils the existence of direct implications of Cgs in the control of behaviour and mood.
Chromogranin B contributes to a highly efficient system that directly mediates monoamine accumulation and exocytosis in large dense core secretory vesicles.
C-terminal domain of chromogranin B regulates intracellular calcium signaling.
CgB is not required for normal insulin (show INS Proteins) granule biogenesis or maintenance in vivo, but is essential for adequate secretion of islet hormones
Chromogranin B gene ablation reduces the catecholamine cargo and decelerates exocytosis in chromaffin secretory vesicles in mice.
CGB was localized in the nucleus; transcription control role of CGB in the nucleus
These data suggest that RAGE (show AGER Proteins) signaling is capable of driving neuronal differentiation involving CREB (show CREB1 Proteins) activation and induction of chromogranin expression.
Chromogranin B has a role in secretory granule biogenesis
CGB may play an important modulatory role in the control of Ca2 (show CA2 Proteins)+ release from the endoplasmic reticulum
Neuroendocrine-specific expression of Chgb is mediated by the CRE and G/C boxes in cis (show CISH Proteins) and the transcription factors CREB (show CREB1 Proteins), AP-2 (show TFAP2A Proteins), Egr-1 (show EGR1 Proteins) and Sp1 (show SP1 Proteins).
Compared with chromogranin A (show CHGA Proteins), chromogranin B may be more useful during proton pump inhibitor treatment and can detect tumors without liver metastases.
our results suggest that genetic variants of CHGB may have sex-specific effects on the risk of schizophrenia and provide useful preliminary information for further study.
Data indicate that measurement of chromogranin A (CgA (show CHGA Proteins)) alone is sufficient in the management of patients with neuroendocrine tumours (NETs) and that routine additional measurement of chromogranin B (CgB) provides little added value.
intracellular calcium binding protein (show CETN1 Proteins) Sg1 (show ZNF750 Proteins) is increased in early multiple sclerosis (MS) patients compared to relapsing-remitting MS and neurological controls.
The polymorphism P413L in the CHGB gene was not associated with sporadic amyotrophic lateral sclerosis in a group of Italian patients.
CgA (show CGA Proteins) and CgB (show CGB Proteins) have been used as general NEN biomarkers for many years, while CART has only recently been identified
A heterogeneous response to short- and long-term physical activities among circulating granin proteins, particularly chromogranin B.
CgA (show CGA Proteins), CgB (show CGB Proteins), and secretoneurin (show SCG2 Proteins) are detectable in feces, and collagenous colitis patients express higher values than patients with inflammatory bowel disease and controls. In treatment, fecal secretoneurin (show SCG2 Proteins) decreased to control levels in collagenous colitis.
Our findings suggest that altered PTEN, ATRX (show ATRX Proteins), CHGA (show CHGA Proteins), and CHGB expression are associated with aggressive PNET phenotype in VHL (show VHL Proteins) and may serve as useful adjunct prognostic markers to Ki-67 (show MKI67 Proteins) in PNETs.
Results do not support the 413L variant of chromogranin B as a risk factor for sporadic amyotrophic lateral sclerosis in the French population.
chromogranin B has a role in the IP(3)-mediated Ca(2 (show CA2 Proteins)+) release mechanism of secretory granules
colocalization of all three inositol 1,4,5-trisphosphate receptor (IP(3)R (show ITPR1 Proteins))isoforms with chromogranin B to the extent that the majority of each IP(3)R (show ITPR1 Proteins) isoform-labeling gold particles found in the nucleoplasm
determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2 (show CA2 Proteins)+) homeostasis in secretory cells
Chromogranin B was found to co-localize with secretogranin II (show SCG2 Proteins) and IP3 receptors in the nucleus, more specifically, in the IP3-sensitive nucleoplasmic Ca2 (show CA2 Proteins)+ store vesicles.
expression and localization of chromogranin A (CgA (show CHGA Proteins)), chromogranin B (CgB), synaptophysin (show SYP Proteins), and insulin (show INS Proteins) were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells
This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides.
, secretogranin I
, secretogranin B
, Chromogranin B, parathyroid secretory protein
, glucagonoma peptide