Chromosome 12 Open Reading Frame 5 Proteins (C12orf5)

C12orf5 is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. Additionally we are shipping Chromosome 12 Open Reading Frame 5 Antibodies (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
C12orf5 57103 Q9NQ88
Mouse C12orf5 C12orf5 319801 Q8BZA9
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Top Chromosome 12 Open Reading Frame 5 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_Escherichia coli (E. coli) Human Un-conjugated   25 μg Log in to see 11 to 12 Days
$241.92
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Human Un-conjugated   2 μg Log in to see 6 Days
$168.54
Details

C12orf5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Chromosome 12 Open Reading Frame 5 (C12orf5) Interaction Partners

Human Chromosome 12 Open Reading Frame 5 (C12orf5) interaction partners

  1. the upregulation of hsamiR101 in ccRCC was induced by hypoxia. Its expression deceased the protein expression of TIGAR and promoted glycolysis. This regulatory pathway may represent a novel mechanism of carcinogenesis and requires further investigation.

  2. TIGAR expression in breast carcinoma cells promotes metabolic compartmentalization and tumor growth with a mitochondrial metabolic phenotype with lactate and glutamine catabolism.

  3. we investigate the crosstalk between PFKFB3 (show PFKFB3 Proteins) and TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator), a protein known to protect cells from oxidative stress. Our results show consistent TIGAR induction in HeLa cells in response to PFKFB3 (show PFKFB3 Proteins) knockdown

  4. The study showed that miR (show MLXIP Proteins)-101 inhibited viability, induced apoptosis, pushed glucose metabolism flux from the pentose phosphate pathway into glycolysis in prostate cancer PC3 (show PCSK1 Proteins) cell line by decreasing NADPH (show NQO1 Proteins) levels by throughly directly binding to 3'-UTR of TIGAR mRNA and repressing TIGAR expression.

  5. This study demonstrated that a high p53 (show TP53 Proteins) expression could be associated with the promotion of glycolysis in gastric cancer via the modulation of TIGAR expression.

  6. TIGAR expression may be used as a bio-marker for detection of colorectal cancer and can be used as a target for developing therapeutics for the treatment of colorectal cancer.

  7. TIGAR knockdown reduced tumor growth rate.

  8. Geranylgeranoic acid induced upregulation of the TIGAR gene, which might inhibit the glycolysis in HuH-7 cells with p53 (show TP53 Proteins) mutation.

  9. TIGAR over-expression could diminish the radiosensitivity of Hs 917.T cells, and the autophagy level induced by ionizing radiation (IR) was also decreased by TIGAR transfection.

  10. The Cdk5 (show CDK5 Proteins)-AMT (show AMT Proteins) signal pathway involved in regulation of DDR (show DDR1 Proteins) by TIGAR.

Mouse (Murine) Chromosome 12 Open Reading Frame 5 (C12orf5) interaction partners

  1. Results suggest that TIGAR expression changes during development and its expression level may be correlated with the vulnerability of neurons to ischemic injury.

  2. Although mouse TIGAR expression is clearly induced in the intestines of mice following DNA-damaging stress of ionizing radiation, that was not dependent on p53 (show TP53 Proteins) or TAp73 (show TP73 Proteins).

  3. TIGAR protein expression in brain is increased following ischemia reperfusion injury.

  4. Therefore, we conclude that TIGAR knockdown-induced radiosensitization of glioma cells may be dependent on the inhibition of TRX1 (show TXN Proteins) nuclear translocation.

  5. TIGAR protects ischemic brain injury and preserves mitochodrial function.

  6. TIGAR has roles in efficient intestinal regeneration and tumorigenesis

  7. p53 (show TP53 Proteins)/TIGAR-mediated inhibition of myocyte mitophagy is responsible for impairment of mitochondrial integrity and subsequent apoptosis.

  8. p53 (show TP53 Proteins) and TIGAR inhibit glycolysis in hypoxic myocytes and that inhibition of glycolysis is closely involved in apoptosis, suggesting that p53 (show TP53 Proteins) and TIGAR are significant mediators of cellular energy homeostasis and cell death under ischemic stress.

Chromosome 12 Open Reading Frame 5 (C12orf5) Protein Profile

Protein Summary

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.

Gene names and symbols associated with C12orf5

  • chromosome 1 open reading frame, human C12orf5 (C1H12ORF5)
  • chromosome 12 open reading frame 5 (c12orf5)
  • chromosome 12 open reading frame 5 (LOC100226990)
  • chromosome 12 open reading frame 5 (C12orf5)
  • chromosome 5 open reading frame, human C12orf5 (C5H12orf5)
  • RIKEN cDNA 9630033F20 gene (9630033F20Rik)
  • AA793651 protein
  • AI595337 protein
  • C12orf5 protein
  • C79710 protein
  • C85509 protein
  • FR2BP protein
  • Tigar protein

Protein level used designations for C12orf5

TP53-induced glycolysis and apoptosis regulator , fructose-2,6-bisphosphatase TIGAR , probable fructose-2,6-bisphosphatase TIGAR , chromosome 12 open reading frame 5 , fructose-2,6-bisphosphate 2-phosphatase , transactivated by NS3TP2 protein

GENE ID SPECIES
419040 Gallus gallus
100145723 Xenopus (Silurana) tropicalis
100226990 Taeniopygia guttata
57103 Homo sapiens
734566 Xenopus laevis
615392 Bos taurus
319801 Mus musculus
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