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Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation.. Additionally we are shipping Chromosome 2 Open Reading Frame 40 Proteins (5) and Chromosome 2 Open Reading Frame 40 Kits (4) and many more products for this protein.
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Human Polyclonal C2orf40 Primary Antibody for EIA, IF - ABIN1450064
Su, Liu, Lu: [Cloning and identification of cDNA fragments related to human esophageal cancer]. in Zhonghua zhong liu za zhi [Chinese journal of oncology] 2000
Show all 3 references for ABIN1450064
Human Polyclonal C2orf40 Primary Antibody for IHC, IHC (p) - ABIN4306960
Baird, Coimbra, Dang, Lopez, Lee, Krzyzaniak, Winfield, Potenza, Eliceiri: Cell surface localization and release of the candidate tumor suppressor Ecrg4 from polymorphonuclear cells and monocytes activate macrophages. in Journal of leukocyte biology 2012
Show all 2 references for ABIN4306960
Human Polyclonal C2orf40 Primary Antibody for IF, IHC - ABIN1534119
Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ... in Nature 2005
low expression or no expression of ECRG4 in esophageal cancer tissues was closely related to the degree of tumor invasion level, TNM (show ODZ1 Antibodies) staging, lymph node metastasis and recurrence and survival after surgery.
loss of ECRG4 protein expression may be involved in tumor progression and may serve as a prognostic biomarker for breast cancer.
Overexpression of ECRG4 inhibited laryngeal cancer cell proliferation and induced cancer cell apoptosis.
Our data suggest that methylation-mediated suppression of the ECRG4 gene occurs frequently in nasopharyngeal carcinoma
Results identify Ecrg4 as a paracrine factor that activates microglia and is chemotactic for monocytes, with potential as an antitumor therapeutic.
ECRG4 is present on the surface of human monocytes and granulocytes and its interaction with the innate immunity receptor complex supports a role for cell surface activation of ECRG4 during inflammation
The expression of ECRG4 is frequently upregulated in a papillary thyroid carcinoma through the demethylation mechanism of CpG islands in the gene promoter region, and the ECRG4 has a tumor-promoting function through inducing the cell cycle transition
ECRG4 is a candidate tumor suppressor gene that might be involved in the proliferation of esophageal squamous cell carcinoma
results suggest that C2ORF40 acts as a tumor suppressor gene in breast cancer pathogenesis and progression and is a candidate prognostic marker for this disease
overexpression of ECRG4 enhanced the chemosensitivity of gastric cancer SGC (show SGCB Antibodies)-7901 cells to 5-FU through induction of apoptosis.
proteolytic cleavage by furin (show FURIN Antibodies) is a posttranslational requirement for proaugurin to suppress cell proliferation
identified esophageal cancer-related gene 4 (Ecrg4) as a senescence inducer with implications for the senescence-like state of postmitotic cells in the aging brain.
ECRG4 level in differentiated chondrocytes is decreased during hypertrophic maturation
Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation.
esophageal cancer related gene 4 protein
, esophageal cancer-related gene 4 protein
, UPF0689 protein C2orf40 homolog
, esophageal cancer-related gene 4 protein homolog