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Chromosome 22 Open Reading Frame 28 Proteins (C22orf28)

Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'- phosphodiester. Additionally we are shipping Chromosome 22 Open Reading Frame 28 Antibodies (50) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse C22orf28 C22orf28 28088 Q99LF4
C22orf28 51493 Q9Y3I0
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Top Chromosome 22 Open Reading Frame 28 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
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C22orf28 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Chromosome 22 Open Reading Frame 28 (C22orf28) Interaction Partners

Mouse (Murine) Chromosome 22 Open Reading Frame 28 (C22orf28) interaction partners

  1. This novel Faap20 mouse model may be valuable in studying the regulation of the FA pathway during bone marrow failure progress in FA patients.

  2. FAAP (D10Wsu52e) mRNA and protein expression are highly regionalized in the mouse epididymis with predominant enrichment in the initial segment; during sexual maturation, FAAP mRNA is always expressed in the caput epididymides

  3. defects in HSPC117 expression may be an important contributing factor to loss of cloned nuclear transfer embryos in vivo.

Human Chromosome 22 Open Reading Frame 28 (C22orf28) interaction partners

  1. RTCB, the catalytic subunit of the tRNA ligase complex, and its co-factor archease mediate XBP1 (show XBP1 Proteins) mRNA splicing both in vitro and in vivo.

  2. hCLE/C14orf166 associates with DDX1, HSPC117, and FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.

  3. Over-expression of HSPC117 mRNA reduced MMP 2 (show MMP2 Proteins) and MMP 14 (show MMP14 Proteins) mRNA expression, while TIMP 2 (show TIMP2 Proteins) mRNA expression was up-regulated.

  4. study identified HSPC117, a member of the UPF0027 (RtcB) family, as the essential subunit of a tRNA ligase complex; RNA interference-mediated depletion of HSPC117 inhibited maturation of intron-containing pre-tRNA both in vitro and in living cells

Chromosome 22 Open Reading Frame 28 (C22orf28) Protein Profile

Protein Summary

Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity). Essential during post-implantation development of embryos.

Gene names and symbols associated with C22orf28

  • chromosome 1 open reading frame, human C22orf28 (C22ORF28)
  • chromosome 22 open reading frame 28 (C22orf28)
  • RNA 2',3'-cyclic phosphate and 5'-OH ligase (rtcb)
  • chromosome 22 open reading frame 28 (c22orf28)
  • chromosome 5 open reading frame, human C22orf28 (C5H22orf28)
  • DNA segment, Chr 10, Wayne State University 52, expressed (D10Wsu52e)
  • RNA 2',3'-cyclic phosphate and 5'-OH ligase (RTCB)
  • tRNA-splicing ligase RtcB homolog (LOC733658)
  • AI255213 protein
  • AI463255 protein
  • C1H22orf28 protein
  • C10H22orf28 protein
  • C22orf28 protein
  • DJ149A16.6 protein
  • FAAP protein
  • HSPC117 protein
  • MGC154502 protein
  • RP1-149A16.6 protein

Protein level used designations for C22orf28

UPF0027 protein C22orf28 homolog , tRNA-splicing ligase RtcB homolog , hypothetical protein LOC717258 , CG9987-like , hypothetical protein LOC779280 , focal adhesion-associated protein , ankyrin repeat domain 54

GENE ID SPECIES
418064 Gallus gallus
100137237 Papio anubis
595066 Xenopus (Silurana) tropicalis
717258 Macaca mulatta
779280 Xenopus laevis
525106 Bos taurus
28088 Mus musculus
51493 Homo sapiens
733658 Sus scrofa
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