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Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'- phosphodiester. Additionally we are shipping Chromosome 22 Open Reading Frame 28 Antibodies (50) and many more products for this protein.
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This novel Faap20 mouse model may be valuable in studying the regulation of the FA pathway during bone marrow failure progress in FA patients.
FAAP (D10Wsu52e) mRNA and protein expression are highly regionalized in the mouse epididymis with predominant enrichment in the initial segment; during sexual maturation, FAAP mRNA is always expressed in the caput epididymides
defects in HSPC117 expression may be an important contributing factor to loss of cloned nuclear transfer embryos in vivo.
RTCB, the catalytic subunit of the tRNA ligase complex, and its co-factor archease mediate XBP1 (show XBP1 Proteins) mRNA splicing both in vitro and in vivo.
hCLE/C14orf166 associates with DDX1, HSPC117, and FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
Over-expression of HSPC117 mRNA reduced MMP 2 (show MMP2 Proteins) and MMP 14 (show MMP14 Proteins) mRNA expression, while TIMP 2 (show TIMP2 Proteins) mRNA expression was up-regulated.
study identified HSPC117, a member of the UPF0027 (RtcB) family, as the essential subunit of a tRNA ligase complex; RNA interference-mediated depletion of HSPC117 inhibited maturation of intron-containing pre-tRNA both in vitro and in living cells
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity). Essential during post-implantation development of embryos.
UPF0027 protein C22orf28 homolog
, tRNA-splicing ligase RtcB homolog
, hypothetical protein LOC717258
, hypothetical protein LOC779280
, focal adhesion-associated protein
, ankyrin repeat domain 54