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Exhibits broad antiviral activity, most probably causing an early viral translation block.. Additionally we are shipping Chromosome 6 Open Reading Frame 150 Proteins (5) and many more products for this protein.
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Cow (Bovine) Polyclonal C6orf150 Primary Antibody for WB - ABIN2785007
Rush, Moritz, Lee, Guo, Goss, Spek, Zhang, Zha, Polakiewicz, Comb: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. in Nature biotechnology 2005
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Human Polyclonal C6orf150 Primary Antibody for EIA, WB - ABIN950947
Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: The DNA sequence and analysis of human chromosome 6. ... in Nature 2003
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cGAS silencing inhibited production of proinflammatory cytokines and matrix metalloproteinases (MMPs) as well as AKT (show AKT1 Antibodies) and ERK (show EPHB2 Antibodies) phosphorylation in TNFalpha (show TNF Antibodies)-stimulated fibroblast-like synoviocytes
A STING-dependent, cGAS-independent pathway important for full interferon (show IFNA Antibodies) production and antiviral control of enveloped RNA viruses.
By directly binding to cGAS, LANA, and particularly, a cytoplasmic isoform, inhibit the cGAS-STING-dependent phosphorylation of TBK1 (show TBK1 Antibodies) and IRF3 (show IRF3 Antibodies) and thereby antagonize the cGAS-mediated restriction of KSHV lytic replication.
TRIM21 (show TRIM21 Antibodies)-induced exposure of the viral genome promotes sensing of DNA and RNA viruses by cGAS and RIG-I (show DDX58 Antibodies)
cGAS is an innate sensor of Mycobacterium tuberculosis.Mycobacterium tuberculosis differentially activates cGAS- and inflammasome-dependent intracellular immune responses through ESX-1 (show ESX1 Antibodies).
Study found that PQBP1 (show PQBP1 Antibodies) directly binds to reverse-transcribed HIV-1 DNA and interacts with cGAS to initiate an IRF3 (show IRF3 Antibodies)-dependent innate response.
Studies in THP-1 (show GLI2 Antibodies) knockout cells revealed that the recognition of RNA:DNA hybrids is completely attributable to the cGAS-STING pathway.
IFI16 (show IFI16 Antibodies) and cGAS cooperate in a novel way to sense nuclear herpesviral DNA and initiate innate signaling
The cGAS/STING/TBK1 (show TBK1 Antibodies)/IRF3 (show IRF3 Antibodies) cascade was not a direct target of viral antihost strategies, and authors found no evidence that adenovirus stimulation of the cGAS/STING DNA response had an impact on viral replication efficiency.
The crystal structures of human cGAS in its apo (show C9orf3 Antibodies) form, representing its autoinhibited conformation as well as in its cGAMP- and sulfate-bound forms, are reported.
Exhibits broad antiviral activity, most probably causing an early viral translation block.
chromosome 6 open reading frame 150
, cGAMP synthase
, cyclic GMP-AMP synthase
, mab-21 domain-containing protein 1
, protein MB21D1