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Exhibits broad antiviral activity, most probably causing an early viral translation block.. Additionally we are shipping Chromosome 6 Open Reading Frame 150 Proteins (5) and many more products for this protein.
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Cow (Bovine) Polyclonal C6orf150 Primary Antibody for WB - ABIN2785007
Rush, Moritz, Lee, Guo, Goss, Spek, Zhang, Zha, Polakiewicz, Comb: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. in Nature biotechnology 2005
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Human Polyclonal C6orf150 Primary Antibody for EIA, WB - ABIN950947
Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: The DNA sequence and analysis of human chromosome 6. ... in Nature 2003
Show all 2 references for ABIN950947
cGAS and STING are intracellular sensors that activate the interferon (show IFNA Antibodies) pathway in response to virus infection. [review]
cGAS silencing inhibited production of proinflammatory cytokines and matrix metalloproteinases (MMPs) as well as AKT (show AKT1 Antibodies) and ERK (show EPHB2 Antibodies) phosphorylation in TNFalpha (show TNF Antibodies)-stimulated fibroblast-like synoviocytes
A STING-dependent, cGAS-independent pathway important for full interferon (show IFNA Antibodies) production and antiviral control of enveloped RNA viruses.
By directly binding to cGAS, LANA, and particularly, a cytoplasmic isoform, inhibit the cGAS-STING-dependent phosphorylation of TBK1 (show TBK1 Antibodies) and IRF3 (show IRF3 Antibodies) and thereby antagonize the cGAS-mediated restriction of KSHV lytic replication.
TRIM21 (show TRIM21 Antibodies)-induced exposure of the viral genome promotes sensing of DNA and RNA viruses by cGAS and RIG-I (show DDX58 Antibodies)
cGAS is an innate sensor of Mycobacterium tuberculosis.Mycobacterium tuberculosis differentially activates cGAS- and inflammasome-dependent intracellular immune responses through ESX-1 (show ESX1 Antibodies).
Study found that PQBP1 (show PQBP1 Antibodies) directly binds to reverse-transcribed HIV-1 DNA and interacts with cGAS to initiate an IRF3 (show IRF3 Antibodies)-dependent innate response.
Studies in THP-1 (show GLI2 Antibodies) knockout cells revealed that the recognition of RNA:DNA hybrids is completely attributable to the cGAS-STING pathway.
IFI16 (show IFI16 Antibodies) and cGAS cooperate in a novel way to sense nuclear herpesviral DNA and initiate innate signaling
The cGAS/STING/TBK1 (show TBK1 Antibodies)/IRF3 (show IRF3 Antibodies) cascade was not a direct target of viral antihost strategies, and authors found no evidence that adenovirus stimulation of the cGAS/STING DNA response had an impact on viral replication efficiency.
Exhibits broad antiviral activity, most probably causing an early viral translation block.
chromosome 6 open reading frame 150
, cGAMP synthase
, cyclic GMP-AMP synthase
, mab-21 domain-containing protein 1
, protein MB21D1