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F9 encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. Additionally we are shipping Coagulation Factor IX Kits (65) and Coagulation Factor IX Proteins (38) and many more products for this protein.
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a computational approach was conducted to select suitable location(s) for introducing new N-glycosylation sites into the human coagulation factor IX.
caspase-3 (show CASP3 Antibodies) inhibitors also suppressed the attenuation of cell adhesion and phosphorylation of p38 MAPK (show MAPK14 Antibodies) by EGF (show EGF Antibodies)-F9. Our data indicated that EGF (show EGF Antibodies)-F9 activated signals for apoptosis and induced de-adhesion in a caspase-3 (show CASP3 Antibodies) dependent manner.
Data suggest that coagulation factor IX (hFIX) minigene containing beta-globin (hBG) introns could represent a particular interest in stem cell-based gene therapy of hemophilias.
miR (show MLXIP Antibodies)-128 and miR (show MLXIP Antibodies)-125 could help to increase the nonsense-mutant F9 levels by repressing nonsense-mediated mRNA decay.
In 293T cells, the addition of 0.5 mM Ca(+2) and 1 mM Mg(+2) resulted in higher recombinant human Factor IX concentration. SK-Hep-1 cell line proved to be very effective in rhFIX production, and it can be used as a novel biotechnological platform for the production of recombinant proteins.
Differentiation studies demonstrated osteogenic (but not chondrogenic or adipogenic) differentiation capability and efficient FIX secretion of the enclosed MSCs in the fibronectin (show FN1 Antibodies)-alginate suspension culture.
Selective disruption of exosite-mediated regulation of factor IX by heparin and antithrombin (show SERPINC1 Antibodies) can be achieved with preserved or enhanced thrombin (show F2 Antibodies) generation capacity.
structural features within residues of the 39-loop contribute to the resistance of FIXa (show ETFB Antibodies) to inhibition by plasma inhibitors ZPI (show SERPINA10 Antibodies) and TFPI (show TFPI Antibodies).
hnRNP A3 is a major liver nuclear protein binding to age related increase element of the factor IX gene.
functional role of binding of F9 to collagen IV (show COL4 Antibodies) in hemostasis.
FIX and FXI (show F11 Antibodies) deficiency cause similar effects in the carotid artery injury model
findings show coagulation factor IX & complement component C4-binding protein can bind Adenovirus fiber knob domain & provide a bridge for virus uptake through cell surface heparan sulfate proteoglycans & low-density lipoprotein receptor (show LDLR Antibodies)-related protein (show LRP1 Antibodies)
Mice lacking plasminogen (show PLG Antibodies) and fIX (Plg (show PLG Antibodies)(-/-)/fIX-/-) have lower mortality at age 6 months than Plg (show PLG Antibodies)(-/-)/fIX+/+ mice
important role for Lyn (show LYN Antibodies) in VWF (show VWF Antibodies)/GPIb-IX-induced integrin activation mediated via the cGMP signaling pathway independently of TXA2 (show TBXA2R Antibodies) synthesis and also indicate that Lyn (show LYN Antibodies) is critically important in GPIb-IX-mediated activation of the cGMP pathway
the heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin (show F2 Antibodies) generation and venous thrombosis
Mg2 (show MCOLN1 Antibodies)+ ions are required to maintain native conformation and in vivo function of factor IX gamma-carboxyglutamic acid domain
This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.
coagulation factor IX
, coagulation factor 9 (plasma thromboplastic component, Christmas disease, hemophilia B)
, gla domain
, coagulation factor 9
, Coagulation factor IX
, coagulation factor IX-like
, Christmas factor
, F9 p22
, FIX F9
, factor 9
, factor IX F9
, plasma thromboplastic component
, plasma thromboplastin component
, christmas factor
, Coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)
, coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)
, factor IX activated protein
, factor IX