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Collagen, Type X, alpha 1 Proteins (COL10A1)

COL10A1 encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Additionally we are shipping Collagen, Type X, alpha 1 Antibodies (20) and Collagen, Type X, alpha 1 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL10A1 1300 Q03692
COL10A1 12813 Q05306
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Top Collagen, Type X, alpha 1 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
$7,759.50
Details

COL10A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Collagen, Type X, alpha 1 (COL10A1) Interaction Partners

Human Collagen, Type X, alpha 1 (COL10A1) interaction partners

  1. increased expression of stromal colXalpha1 and low TILs correlate with poor pathologic response in ER+/HER2 (show ERBB2 Proteins)+ breast tumors. Further studies are needed to confirm their predictive value and impact on long-term outcomes, and to determine whether this collagen exerts a protective effect on the cancer cells or simply reflects other factors within the tumor microenvironment

  2. a novel sequence variation involving an unusual mutational site of the COL10A1 gene can cause mild metaphyseal chondrodysplasia

  3. COL10A1 mutation 2005delC in a Chinese pedigree with Schmid type metaphyseal chondrodysplasia is close to the C-terminus of the protein sequence and may result in genetic heterogeneity of the Chinese population

  4. The results show that COL10A1 is a tumor biomarker upregulated in a wide variety of tumors including those of the breast, colon, bladder, stomach, esophagus, lung, testis, ovary and pancreas.

  5. Yiqi Huayu Bushen Recipe increased the expression of aggrecan (show ACAN Proteins), decreased the expression of type X collagen, and promoted cell proliferation in cells from degenerated human intervertebral discs.

  6. Genetic variation near FRK (show FRK Proteins)/COL10A1 and VEGFA (show VEGFA Proteins) are associated with advanced age-related macular degeneration.

  7. MCDS is a rare genetic skeletal disorder caused by a collagen type X defect. Though much is known about the molecular pathology of the causative COL10A1 mutations, causal therapy of the disease is not yet available

  8. a frameshift mutation leading to elongation of the deduced alpha1(X) chain associated with Metaphyseal Chondrodysplasia type Schmid

  9. The effect of parathyroid hormone on expression of COL10 and COL2 in mesenchymal stem cells from osteoarthritic patients and analyzed the potential mechanisms related to its effect, was investigated.

  10. These results indicate that nitrogen-rich plasma polymerized surfaces inhibit COL10A1 expression via the suppression of COX-1.

Mouse (Murine) Collagen, Type X, alpha 1 (COL10A1) interaction partners

  1. In a model of instability-induced osteoarthritis, Col (show HDAC1 Proteins) X was overexpressed in articular chondrocytes and osteophyte-forming cells in LOX-1 (show OLR1 Proteins)(+)/(+) mice and was significantly downregulated in articular chondrocytes and osteophyte-forming cells in LOX-1 (show OLR1 Proteins)(-)/(-) mice.

  2. Col10 expression was seen in the hypertrophic zone at and below the tidemark of the mandibular condyle cartilage.

  3. These data support a Cox-2-containing, Runx2 (show RUNX2 Proteins)-centered Col10a1 regulatory mechanism, during chondrocyte hypertrophic differentiation.

  4. Data indicate Indian hedgehog (Ihh (show IHH Proteins)) induces collagen type X COL10A1 expression and promotes its transcription through Runx2 (show RUNX2 Proteins)/Smad1 (show SMAD1 Proteins) interactions on a specific promoter region.

  5. these results show that increased Col10a1 expression in Phex (show PHEX Proteins)-deficient osteoblasts is not a major cause of the XLHR phenotype, which was an important issue to address based on the previous findings

  6. Downregulation of carbonic anhydrase IX (show CA9 Proteins) promotes Col10a1 expression in chondrocytes.

  7. Runx2 (show RUNX2 Proteins) directly interacts with murine Col10a1 cis (show CISH Proteins)-enhancer.

  8. SOX9 (show SOX9 Proteins) directly represses Col10a1 expression in immature/proliferating chondrocytes of the growth plate

  9. Studies indicate that Col10a1 is highly expressed in hypertrophic chondrocytes and commonly used as a gene marker for this cell population.

  10. cartilaginous regeneration is due to the expression of chondrogenic factors, such as Sox 9 (show SOX9 Proteins) and type II and X collagens

Cow (Bovine) Collagen, Type X, alpha 1 (COL10A1) interaction partners

  1. The 4.6 kb promoter is able to drive specific expression of Col10a1 in hypertrophic cartilage.

  2. TSG is an important modulator of BMP-regulated induced collagen II and X expression and cartilage development and chondrocyte differentiation

Collagen, Type X, alpha 1 (COL10A1) Protein Profile

Protein Summary

This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).

Gene names and symbols associated with COL10A1

  • collagen alpha-1(X) chain-like (LOC100858979)
  • collagen, type X, alpha 1 (COL10A1)
  • collagen, type X, alpha 1 (Col10a1)
  • Col10 protein
  • Col10a-1 protein

Protein level used designations for COL10A1

Schmid metaphyseal chondrodysplasia , collagen X, alpha-1 polypeptide , collagen alpha-1(X) chain , procollagen, type X, alpha 1 , collagen, type X, alpha 1 (Schmid metaphyseal chondrodysplasia) , collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia) , type X collagen alpha 1

GENE ID SPECIES
100858979 Gallus gallus
1300 Homo sapiens
12813 Mus musculus
282416 Bos taurus
100126150 Gallus gallus
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