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Collagen, Type XVIII, alpha 1 Proteins (COL18A1)

COL18A1 encodes the alpha chain of type XVIII collagen. Additionally we are shipping COL18A1 Antibodies (155) and COL18A1 Kits (69) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL18A1 80781 P39060
COL18A1 12822 P39061
COL18A1 85251  
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Top COL18A1 Proteins at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 10 to 12 Days
$206.55
Details
HOST_HEK-293 Mouse Un-conjugated   25 μg Log in to see 10 to 12 Days
$103.27
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 50 μg Log in to see 9 to 11 Days
$506.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$215.25
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 7 to 9 Days
$328.21
Details
HOST_Yeast (Pichia pastoris) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$215.25
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   0.1 mg Log in to see 2 to 3 Days
$309.38
Details
HOST_Yeast (Pichia pastoris) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$190.93
Details

COL18A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine) ,

Rat (Rattus)

Top referenced COL18A1 Proteins

  1. Human COL18A1 Protein expressed in Escherichia coli (E. coli) - ABIN2666547 : Faye, Chautard, Olsen, Ricard-Blum: The first draft of the endostatin interaction network. in The Journal of biological chemistry 2009 (PubMed)
    Show all 5 references for ABIN2666547

  2. Mouse (Murine) COL18A1 Protein expressed in HEK-293 - ABIN2666580 : Sund, Hamano, Sugimoto, Sudhakar, Soubasakos, Yerramalla, Benjamin, Lawler, Kieran, Shah, Kalluri: Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Show all 5 references for ABIN2666580

More Proteins for Collagen, Type XVIII, alpha 1 (COL18A1) Interaction Partners

Pig (Porcine) Collagen, Type XVIII, alpha 1 (COL18A1) interaction partners

  1. Investigate the timecourse of collagen XVIII processing with release of endostatin (ES) and other low-molecular-weight fragments during early ischemia-reperfusion of the heart.

Zebrafish Collagen, Type XVIII, alpha 1 (COL18A1) interaction partners

  1. Together these data suggest that Lh3 (show PLOD3 Proteins)-Collagen18A1 dependent ECM (show MMRN1 Proteins) modifications regulate the transition of trunk neural crest cells from a non-segmental sheet like migration mode to a segmental stream migration mode

  2. These results provide important insight into the biological function and regulation of COL18A1, and point to additional sequences that may contribute to complex diseases involving COL18A1.

  3. diwanka (lh3 (show PLOD3 Proteins)) acts through myotomal type XVIII collagen, a ligand for neural-receptor protein tyrosine phosphatases that guide motor axons

Human Collagen, Type XVIII, alpha 1 (COL18A1) interaction partners

  1. Endostatin is increased in patients with primary sjogren's syndrome patients with interstitial lung disease.

  2. Data show that endostatin levels were elevated in patients with systemic sclerosis (SSc (show CYP11A1 Proteins)) and mixed connective tissue disease (MCTD).

  3. Collaterals formation seems to be associated with the activation of pro-inflammatory factors, growth factors and endostatin in chronic heart failure.

  4. Genebased analyses revealed associations of the COL18A1 gene with longitudinal Blood Pressure phenotypes, associations with essential hypertension, Blood Pressure salt sensitivity, preeclampsia, or preclinical stages of atherosclerosis.

  5. Study demonstrates that endostatin has novel ATPase activity, which mediates its antiangiogenic and antitumor activities.

  6. ADAM8 (show ADAM8 Proteins) and endostatin play a role in osteosarcoma progression.

  7. the intima+media of IPAH vessels, collagens (COL4A5 (show COL4a5 Proteins), COL14A1 (show COL14A1 Proteins), and COL18A1), matrix metalloproteinase (show MMP20 Proteins) (MMP) 19 (show MMP19 Proteins), and a disintegrin and metalloprotease (show ADAM8 Proteins) (ADAM) 33 (show ADAM33 Proteins) were higher expressed, whereas MMP10 (show MMP10 Proteins), ADAM17 (show ADAM17 Proteins), TIMP1 (show TIMP1 Proteins), and TIMP3 (show TIMP3 Proteins) were less abundant.

  8. High endostatin expression is associated with malignant pleural effusions in lung cancer.

  9. In 2 large cohort studies using serum endostatin as a marker for disease severity and mortality in pulmonary arterial hypertension, a variant in the gene encoding ES, Col18a1, was linked independently with reduced mortality.

  10. Serum endostatin is raised in older men who have symptoms of intermittent claudication.

Mouse (Murine) Collagen, Type XVIII, alpha 1 (COL18A1) interaction partners

  1. There are correlations between the elevation of endostatin levels and parallel microvascular rarefaction and induction of renal fibrosis in aging mice.

  2. An excess of the collagen XVIII Tsp-1 (show GZMA Proteins) domain is deleterious in the eye, possibly by impairing certain functions of the full-length molecule.

  3. The results of the present study indicate endostatin promotes soft callus formation but inhibits callus remodeling during fracture healing most probably by an inhibition of angiogenesis.

  4. Data indicate that delivery by attenuated Salmonella of the combination therapeutic plasmid simultaneously knocked down the expression of Stat3 (show STAT3 Proteins) and resulted in over-expression of Endostatin, which synergistically inhibited prostate cancer growth.

  5. Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition

  6. Women with early-onset, but not late-onset preeclampsia have higher levels of endostatin than healthy pregnant women in corresponding lengths of gestation.

  7. In vivo, Collagen XVIII/endostatin does not play an indispensable role in skeletal development

  8. Lack of collagen XVIII/endostatin results in eye abnormalities.

  9. Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis

  10. Endostatin expression effectively inhibits mammary neoplasms growth in nude mice

COL18A1 Protein Profile

Protein Summary

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with COL18A1

  • collagen, type XVIII, alpha 1 (COL18A1)
  • collagen, type XVIII, alpha 1 (col18a1)
  • collagen type XVIII, alpha 1 (col18a1)
  • collagen, type XVIII, alpha 1 (Col18a1)
  • cb371 protein
  • cb529 protein
  • fc96d06 protein
  • KNO protein
  • KNO1 protein
  • KS protein
  • sb:cb529 protein
  • wu:fb47h10 protein
  • wu:fb77g12 protein
  • wu:fc50f04 protein
  • wu:fc96d06 protein
  • wu:fk02h12 protein

Protein level used designations for COL18A1

collagen, type XVIII, alpha 1 , alpha 1 type XVIII collagen , collagen alpha-1(XVIII) chain , procollagen, type XVIII, alpha 1 , collagen alpha-1(XVIII) chain-like , endostatin , antiangiogenic agent , multi-functional protein MFP

GENE ID SPECIES
373978 Gallus gallus
394845 Xenopus (Silurana) tropicalis
474050 Pan troglodytes
508076 Bos taurus
100464575 Ailuropoda melanoleuca
100579175 Sus scrofa
564123 Danio rerio
80781 Homo sapiens
12822 Mus musculus
100126771 Canis lupus familiaris
85251 Rattus norvegicus
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