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Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Proteins (CBFA2T2)

In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. Additionally we are shipping Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Antibodies (84) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CBFA2T2 CBFA2T2 296293  
CBFA2T2 12396 O70374
CBFA2T2 9139 O43439
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Top Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CBFA2T2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) Interaction Partners

Mouse (Murine) Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) interaction partners

  1. This repressive function is mediated through an ETO (show RUNX1T1 Proteins)-family co-repressor Mtgr1, which tightly binds to the pre-SET/SET domains of Prdm14 (show PRDM14 Proteins) and co-occupies its genomic targets in mouse embryonic stem cells.

  2. Cbfa2t2(-/-) mice display severe defects in pri (show PRDM14 Proteins)mordial germ cell maturation and epigenetic reprogramming

  3. MTGR1 is required for tumorigenesis in the murine AOM (show COL2A1 Proteins)/DSS (show PMP22 Proteins) colitis-associated carcinoma model.

  4. Loss of Mtgr1 impairs the maturation of secretory cells in the small intestine.

  5. Mtgr1 has an important role in crypt survival and regeneration after colonic epithelial ulceration.

  6. c-Myc (show MYC Proteins), a transcriptional target of the Wnt (show WNT2 Proteins) pathway, was overexpressed in the small intestines of mice lacking Mtgr1, thus linking inactivation of Mtgr1 to the activation of a potent oncogene (show RAB1A Proteins)

  7. Eto2 (show CBFA2T3 Proteins) and Mtgr1 as authentic interaction partners of Tal1 (show TAL1 Proteins) and suggest they act as heteromeric corepressors of this bHLH transcription factor (show MSGN1 Proteins) during erythroid differentiation.

Human Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) interaction partners

  1. CBFA2T2 forms a biochemical complex with PRDM14 (show PRDM14 Proteins), a germline-specific transcription factor; mechanistically, CBFA2T2 oligomerizes to form a scaffold upon which PRDM14 (show PRDM14 Proteins) and OCT4 (show POU5F1 Proteins) are stabilized on chromatin

  2. The MTGR1 gene depends on a GC-box-rich sequence for transcriptional regulation and possible ubiquitous expression.

  3. report characterization of two chimeric transcripts identified in AML translocation cases involving CBFA2T2 and C20orf112

  4. ETO (show RUNX1T1 Proteins) family member-mediated oligomerization and repression can be distinct events and that interaction between ETO (show RUNX1T1 Proteins) family members and hSIN3B or N-CoR (show NCOR1 Proteins) may not necessarily strengthen transcriptional repression.

  5. These results reveal novel contributions of MTGR1 and GFI1 to the regulation of neurite outgrowth and identify novel repressors of integrin-dependent neurite outgrowth.

Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) Protein Profile

Protein Summary

In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Gene names and symbols associated with CBFA2T2

  • core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (Cbfa2t2)
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (CBFA2T2)
  • core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) (Cbfa2t2)
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (cbfa2t2)
  • A430091M07 protein
  • C330013D05Rik protein
  • cbfa2t2-a protein
  • Cbfa2t2h protein
  • EHT protein
  • MTGR1 protein
  • p85 protein
  • XETOR protein
  • ZMYND3 protein

Protein level used designations for CBFA2T2

translocated to, 2 , myeloid translocation gene-related protein 1 , protein CBFA2T2 , CBFA2T2 identified gene homolog , MTG8-like protein , MTG8-related protein 1 , core-binding factor runt domain alpha subunit 2 translocated to 2 homolog , core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog , ETO homolog on chromosome 20 , ETO homologous on chromosome 20 , myeloid translocation-related protein 1 , a subunit 2; translocated to, 2 , expressed during neurogenesis

GENE ID SPECIES
296293 Rattus norvegicus
419155 Gallus gallus
12396 Mus musculus
9139 Homo sapiens
379213 Xenopus laevis
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