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anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Antibodies

CBFA2T3 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. Additionally we are shipping Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CBFA2T3 12398 O54972
CBFA2T3 863 O75081
CBFA2T3 361431  
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Top anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Antibodies at antibodies-online.com

Showing 10 out of 28 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-CBFA2T3 Antibody Titration: 0.2-1 ug/mlPositive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MTG16 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Chicken Rabbit Un-conjugated WB Hum. Adult Placenta; Host: Rabbit. Target Name: CHAD . Sample Tissue: Human Adult Placenta . Antibody Dilution: 1.0ug/ml.; CBFA2T3 antibody - N-terminal region in Hum. Adult Placenta cells using Western Blot Human Jurkat; WB Suggested Anti-CBFA2T3 Antibody Titration: 0.2-1 ug/ml. Positive Control: Jurkat cell lysate. CBFA2T3 is supported by BioGPS gene expression data to be expressed in Jurkat.; CBFA2T3 antibody - N-terminal region in Human Jurkat cells using Western Blot 50 μg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CBFA2T3 Antibody Titration: 2.5ug/mlELISA Titer: 1:312500Positive Control: Jurkat cell lysate WB Suggested Anti-CBFA2T3  Antibody Titration: 2.5 µg/mL ELISA Titer: 1:.12500  Positive Control: Jurkat cell lysate  CBFA2T3 is supported by BioGPS gene expression data to be expressed in Jurkat 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), ELISA 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated IHC, ELISA 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated ELISA, IHC   100 μL Log in to see 14 Days
$201.19
Details

CBFA2T3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , ,


Human , ,
,

Rat (Rattus)


Top referenced anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Antibodies

  1. Human Polyclonal CBFA2T3 Primary Antibody for IHC, ELISA - ABIN1533845 : Gamou, Kitamura, Hosoda, Shimizu, Shinohara, Hayashi, Nagase, Yokoyama, Ohki: The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. in Blood 1998 (PubMed)
    Show all 3 references for ABIN1533845

  2. Chicken Polyclonal CBFA2T3 Primary Antibody for WB - ABIN2778220 : Powell, Gardner, Bais, Hinze, Baker, Whitmore, Crawford, Kochetkova, Spendlove, Doggett, Sutherland, Callen, Kremmidiotis: Sequencing, transcript identification, and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor genes. in Genomics 2002 (PubMed)

More Antibodies against Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Interaction Partners

Mouse (Murine) Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) interaction partners

  1. MTG16 loss promotes radioresistance and impacts intestinal stem cell function, possibly due to shifting cellular response away from DNA damage-induced apoptosis and towards DNA repair after injury.

  2. Mtg16 promotes plasmacytoid dendritic cell differentiation and restricts classical dendritic cell development in part by repressing Id2.

  3. MTG16 is critical for colonocyte survival and regeneration in response to intestinal injury and provide evidence that this transcriptional corepressor regulates inflammatory recruitment in response to injury.

  4. Mtg16 integrates the activities of signaling pathways and nuclear factors in the establishment of T-cell fate specification.

  5. Data suggest that MTG16 interfaces with critical components of the Notch (show NOTCH1 Antibodies) transcription complex to affect Notch (show NOTCH1 Antibodies)-dependent lineage allocation in hematopoiesis.

  6. association with T-cell acute lymphocytic leukemia 1, ETO-2 represses gene expression in the early stages of erythroid differentiation

  7. The dynamics of ETO2 recruitment within nuclear complexes couple cell proliferation to cell differentiation and determine the onset of terminal erythroid maturation.

  8. MTG8/ETO (show RUNX1T1 Antibodies) and Mtg16 (also known as ETO2) associated with TCF4 (show TCF4 Antibodies)

  9. These data suggest that ETO2 directly represses inappropriate early expression of a subset of terminally expressed megakaryocyte genes by binding to GATA1 (show GATA1 Antibodies) and SCL (show TAL1 Antibodies).

  10. the transcriptional corepressor Mtg16 (myeloid translocation gene on chromosome 16), which is targeted by t(16;21) in acute myeloid leukemia (show BCL11A Antibodies), is required for hematopoietic progenitor cell fate decisions and for early progenitor cell proliferation.

Human Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) interaction partners

  1. ETO2 and IRF2BP2 (show IRF2BP2 Antibodies) interacting with the NCOR1 (show NCOR1 Antibodies)/SMRT (show NCOR2 Antibodies) co-repressor complex, suppresses the expression of erythroid genes until erythroid differentiation.

  2. MTG16 co-repressor promotes degradation of HIF1alpha (show HIF1A Antibodies) in lymphoblasts.

  3. study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP (show CREBBP Antibodies), CBFA2T3, AMOTL1 (show AMOTL1 Antibodies), FAT4 (show FAT4 Antibodies), FBXO11 (show FBXO11 Antibodies), PLA2G4D, TRRAP (show TRRAP Antibodies) and USH2A (show USH2A Antibodies).

  4. Findings are unprecedented and indicate that the DHH (show DHH Antibodies)-RHEBL1 (show RHEBL1 Antibodies) fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3-GLIS2 (show GLIS2 Antibodies)-positive childhood AML (show RUNX1 Antibodies).

  5. Expression of MTG16 reduced glycolytic metabolism while mitochondrial respiration and formation of reactive oxygen species increased.

  6. presence of MTG16 in this complex, and its contributions to transcriptional repression both required Kaiso (show ZBTB33 Antibodies) binding to its binding site on DNA, establishing MTG16-Kaiso (show ZBTB33 Antibodies) binding as functionally relevant in Kaiso (show ZBTB33 Antibodies)-dependent transcriptional repression

  7. Data indicate taht ETO2/CBFA2T3 regulates GATA-1 (show GATA1 Antibodies) target genes critical for erythroid differentiation, and the decrease of ETO2 levels during erythroid differentiation would contribute to the activation of these targets.

  8. Identification of a cryptic chromosome 16 inversion (inv (show INVS Antibodies)(16)(p13.3q24.3)) in 27% of pediatric acute megakaryoblastic leukemia cases, which encodes a CBFA2T3-GLIS2 (show GLIS2 Antibodies) fusion protein.

  9. An evolutionary conserved GATA (show QRSL1 Antibodies) binding site is critical in transcriptional regulation of the MTG16 promoter.

  10. Our data indicate that the CBFA2T3/ACSF3 (show ACSF3 Antibodies) locus is a novel recurrent oncogenic target of immunoglobulin heavy chain translocations, which might contribute to the pathogenesis of pediatric GC-derived B-cell lymphoma.

Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Antigen Profile

Protein Summary

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16\;21)(q24\;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.

Gene names and symbols associated with CBFA2T3

  • core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) (Cbfa2t3) antibody
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (CBFA2T3) antibody
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (Cbfa2t3) antibody
  • A630044F12Rik antibody
  • AI465270 antibody
  • AW229127 antibody
  • Cbfa2t3h antibody
  • ETO-2 antibody
  • ETO2 antibody
  • MTG16 antibody
  • MTG16a antibody
  • MTG16b antibody
  • MTGR2 antibody
  • ZMYND4 antibody

Protein level used designations for CBFA2T3

ETO/MTG8-related protein ETO-2 , MTG8-related protein 2 , core-binding factor, runt domain, alpha subunit 2; translocated to, 3 homolog; CBFA2T3 identified gene homolog , eight twenty one protein 2 , myeloid translocation gene-related protein 2 , protein CBFA2T3 , protein ETO-2 , MTG8-related gene 2 , myeloid translocation gene 8 and 16b , myeloid translocation gene on chromosome 16 protein , zinc finger MYND domain-containing protein 4 , translocated to, 3

GENE ID SPECIES
12398 Mus musculus
415846 Gallus gallus
863 Homo sapiens
361431 Rattus norvegicus
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