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Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Proteins (CBFA2T3)

CBFA2T3 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. Additionally we are shipping Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Antibodies (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CBFA2T3 12398 O54972
CBFA2T3 863 O75081
Rat CBFA2T3 CBFA2T3 361431  
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Top Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CBFA2T3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Interaction Partners

Mouse (Murine) Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) interaction partners

  1. MTG16 loss promotes radioresistance and impacts intestinal stem cell function, possibly due to shifting cellular response away from DNA damage-induced apoptosis and towards DNA repair after injury.

  2. Mtg16 promotes plasmacytoid dendritic cell differentiation and restricts classical dendritic cell development in part by repressing Id2.

  3. MTG16 is critical for colonocyte survival and regeneration in response to intestinal injury and provide evidence that this transcriptional corepressor regulates inflammatory recruitment in response to injury.

  4. Mtg16 integrates the activities of signaling pathways and nuclear factors in the establishment of T-cell fate specification.

  5. Data suggest that MTG16 interfaces with critical components of the Notch (show NOTCH1 Proteins) transcription complex to affect Notch (show NOTCH1 Proteins)-dependent lineage allocation in hematopoiesis.

  6. association with T-cell acute lymphocytic leukemia 1, ETO-2 represses gene expression in the early stages of erythroid differentiation

  7. The dynamics of ETO2 recruitment within nuclear complexes couple cell proliferation to cell differentiation and determine the onset of terminal erythroid maturation.

  8. MTG8/ETO (show RUNX1T1 Proteins) and Mtg16 (also known as ETO2) associated with TCF4 (show TCF4 Proteins)

  9. These data suggest that ETO2 directly represses inappropriate early expression of a subset of terminally expressed megakaryocyte genes by binding to GATA1 (show GATA1 Proteins) and SCL (show TAL1 Proteins).

  10. the transcriptional corepressor Mtg16 (myeloid translocation gene on chromosome 16), which is targeted by t(16;21) in acute myeloid leukemia (show BCL11A Proteins), is required for hematopoietic progenitor cell fate decisions and for early progenitor cell proliferation.

Human Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) interaction partners

  1. ETO2 and IRF2BP2 interacting with the NCOR1/SMRT co-repressor complex, suppresses the expression of erythroid genes until erythroid differentiation.

  2. MTG16 co-repressor promotes degradation of HIF1alpha (show HIF1A Proteins) in lymphoblasts.

  3. study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP, CBFA2T3, AMOTL1, FAT4, FBXO11, PLA2G4D, TRRAP and USH2A.

  4. Findings are unprecedented and indicate that the DHH (show DHH Proteins)-RHEBL1 (show RHEBL1 Proteins) fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3-GLIS2 (show GLIS2 Proteins)-positive childhood AML (show RUNX1 Proteins).

  5. Expression of MTG16 reduced glycolytic metabolism while mitochondrial respiration and formation of reactive oxygen species increased.

  6. presence of MTG16 in this complex, and its contributions to transcriptional repression both required Kaiso (show ZBTB33 Proteins) binding to its binding site on DNA, establishing MTG16-Kaiso (show ZBTB33 Proteins) binding as functionally relevant in Kaiso (show ZBTB33 Proteins)-dependent transcriptional repression

  7. Data indicate taht ETO2/CBFA2T3 regulates GATA-1 (show GATA1 Proteins) target genes critical for erythroid differentiation, and the decrease of ETO2 levels during erythroid differentiation would contribute to the activation of these targets.

  8. Identification of a cryptic chromosome 16 inversion (inv (show INVS Proteins)(16)(p13.3q24.3)) in 27% of pediatric acute megakaryoblastic leukemia cases, which encodes a CBFA2T3-GLIS2 (show GLIS2 Proteins) fusion protein.

  9. An evolutionary conserved GATA (show QRSL1 Proteins) binding site is critical in transcriptional regulation of the MTG16 promoter.

  10. Our data indicate that the CBFA2T3/ACSF3 (show ACSF3 Proteins) locus is a novel recurrent oncogenic target of immunoglobulin heavy chain translocations, which might contribute to the pathogenesis of pediatric GC-derived B-cell lymphoma.

Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Protein Profile

Protein Summary

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16\;21)(q24\;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.

Gene names and symbols associated with CBFA2T3

  • core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) (Cbfa2t3)
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (CBFA2T3)
  • core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (Cbfa2t3)
  • A630044F12Rik protein
  • AI465270 protein
  • AW229127 protein
  • Cbfa2t3h protein
  • ETO-2 protein
  • ETO2 protein
  • MTG16 protein
  • MTG16a protein
  • MTG16b protein
  • MTGR2 protein
  • ZMYND4 protein

Protein level used designations for CBFA2T3

ETO/MTG8-related protein ETO-2 , MTG8-related protein 2 , core-binding factor, runt domain, alpha subunit 2; translocated to, 3 homolog; CBFA2T3 identified gene homolog , eight twenty one protein 2 , myeloid translocation gene-related protein 2 , protein CBFA2T3 , protein ETO-2 , MTG8-related gene 2 , myeloid translocation gene 8 and 16b , myeloid translocation gene on chromosome 16 protein , zinc finger MYND domain-containing protein 4 , translocated to, 3

GENE ID SPECIES
12398 Mus musculus
415846 Gallus gallus
863 Homo sapiens
361431 Rattus norvegicus
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