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CDSN encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. Additionally we are shipping Corneodesmosin Kits (35) and Corneodesmosin Antibodies (32) and many more products for this protein.
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Investigated potential direct protein-protein interactions between six late cornified envelope (LCE) proteins and two corneodesmosin sequence variants. Partial colocalization of LCE2 and CDSN was observed in normal and psoriasis skin.
we report a patient with PSD (show PSD Proteins) caused by a novel homozygous large deletion in the 6p21.3 region encompassing the CDSN gene, which abrogates CDSN expression
Case Report: homozygous deletion of CDSN was considered to be responsible for generalized peeling skin disease.
PSORS1C1 (show PSORS1C1 Proteins)/CDSN gene may play a pathogenic role in ankylosing spondylitis
A nonsense mutation (C717G) in cDNA sequence of the CDSN gene was identified in all three patients of the family.
CDSN -619C/T polymorphism may not be associated with susceptibility to psoriasis.
CDSN plays a vital role in the structural and functional integrity of the epidermis and the hair follicle integrity by preventing the rupture of corneodesmosome.
identified mRNA transcripts from three genes CDSN, LOR (show LOR Proteins) and KRT9 (show KRT9 Proteins), showing strong over-expression in skin samples relative to samples from forensic body fluids, making them suitable markers for skin identification
Study of consangunity in a large family points to a homozygous nonesense mutation of the gene coding for corneodesmosin.
The distribution of corneodesmosin on the surface of the stratum corneum was mapped at the nanoscale using atomic force microscopy.
These results underscore the essential roles of CDSN in hair physiology and suggest functional relevance of CDSN gene polymorphisms to psoriasis susceptibility.
This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. During maturation of the cornified layers, the protein undergoes a series of cleavages, which are thought to be required for desquamation. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.
, differentiated keratinocyte S protein
, s protein