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Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. Additionally we are shipping CRYAB Kits (45) and CRYAB Proteins (36) and many more products for this protein.
Showing 10 out of 454 products:
Cow (Bovine) Monoclonal CRYAB Primary Antibody for ELISA, ICC - ABIN361808
Bullard, Ferguson, Minajeva, Leake, Gautel, Labeit, Ding, Labeit, Horwitz, Leonard, Linke: Association of the chaperone alphaB-crystallin with titin in heart muscle. in The Journal of biological chemistry 2004
Show all 13 references for ABIN361808
Human Monoclonal CRYAB Primary Antibody for WB - ABIN393435
Kida, Wierzba-Bobrowicz, Palminiello, Kaur, Jarzabek, Walus, Albertini, Golabek: Molecular chaperone alphaB-crystallin is expressed in the human fetal telencephalon at midgestation by a subset of progenitor cells. in Journal of neuropathology and experimental neurology 2010
Show all 5 references for ABIN393435
Human Monoclonal CRYAB Primary Antibody for WB - ABIN1944889
Kramps, de Man, de Jong: The primary structure of the B2 chain of human alpha-crystallin. in FEBS letters 1977
Show all 4 references for ABIN1944889
Human Polyclonal CRYAB Primary Antibody for IHC, ELISA - ABIN1532587
Dubin, Ally, Chung, Piatigorsky: Human alpha B-crystallin gene and preferential promoter function in lens. in Genomics 1990
Show all 2 references for ABIN1532587
Human Polyclonal CRYAB Primary Antibody for IHC, ELISA - ABIN1532588
Kovalyov, Shishkin, Efimochkin, Kovalyova, Ershova, Egorov, Musalyamov: The major protein expression profile and two-dimensional protein database of human heart. in Electrophoresis 1996
Show all 2 references for ABIN1532588
Human Polyclonal CRYAB Primary Antibody for IHC (p), WB - ABIN657620
Martins-de-Souza, Schmitt, Röder, Lebar, Schneider-Axmann, Falkai, Turck: Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia. in Journal of psychiatric research 2010
Human Polyclonal CRYAB Primary Antibody for ELISA, WB - ABIN238599
Ousman, Tomooka, van Noort, Wawrousek, OConnor, Hafler, Sobel, Robinson, Steinman: Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. in Nature 2007
This study clearly demonstrated that both the length and electrostatic charge of the COOH-terminal segment play crucial roles in governing the structural stability and chaperone activity of alphaB-crystallin.
This work examines the molecular mechanism by which two canonical sHsps, alphaB-crystallin (alphaB-c) and Hsp27 (show HSPB1 Antibodies), interact with aggregation-prone alpha-syn to prevent its aggregation in vitro Both sHsps are very effective inhibitors of alpha-syn aggregation
343delT/343delT and WT KI/343delT-induced pluripotent stem cell-derived skeletal myotubes and cardiomyocytes did not express detectable levels of 343delT protein, contributable to the extreme insolubility of the mutant protein. Overexpression of HSPB5 343delT resulted in insoluble mutant protein aggregates and induction of a cellular stress response.
Study suggests that wild-type and mutant alphaB-Cry (show CRY2 Antibodies) have dissimilar secondary and tertiary structures. Moreover, alphaB-Cry (show CRY2 Antibodies) indicates slightly improved chaperone activity upon the R12C mutation. These results may explain to some extent the non-cataractogenic nature of R12C mutation in aB-Cry (show CRY2 Antibodies).
Cryab expression was elevated in osteosarcoma tissues and cell lines, and down-regulation of Cryab in MG-63 and U-2OS cells led to a decline in the cells' aggressiveness, and reduced secretion of matrix metalloproteinase-9 (show MMP9 Antibodies) in vitro, and lower metastasis potential in vivo.
Identifies alphaB-crystallin as a new binding partner for Nav1.5 (show SCN5A Antibodies). alphaB-Crystallin interacts with Nav1.5 (show SCN5A Antibodies) and increases INa (show INA Antibodies) by modulating the expression level and internalization of cell surface Nav1.5 (show SCN5A Antibodies) and ubiquitination of Nav1.5 (show SCN5A Antibodies), which requires the protein-protein interactions between alphaB-crystallin and Nav1.5 (show SCN5A Antibodies) and between alphaB-crystallin and functionally active Nedd4-2 (show NEDD4L Antibodies).
alphaB-crystallin is an important regulator of epithelial-mesenchymal transition, acting as a molecular chaperone (show HSP90AA1 Antibodies) for SMAD4 (show SMAD4 Antibodies) and as its potential therapeutic target for preventing subretinal fibrosis development in neovascular age-related macular degeneration
alpha B crystallin is an independent prognostic factor of infiltrating ductal carcinoma of the breast
two novel missense mutations, p.R11C and p.R12C, in CRYAB associated with autosomal recessive congenital nuclear cataracts.
Similar to wild type alphaA- and alphaB-crystallins, the deamidated mutants showed strong interaction with betaA3-crystallin (show CRYBA1 Antibodies).
Phosphorylation of alphaB-crystallin has dual role that manifests either beneficial or deleterious consequences depending on the extent of phosphorylation and interaction with cytoskeleton. [review]
This study demonstrated that HspB5 mRNA localization in myelin-enriched white and gray matter
It is a non-Hsp gene, which is essential for HSF1 (show HSF1 Antibodies)-mediated maintenance of whole body homeostasis.
A previously unrecognized link between c-Jun (show JUN Antibodies) and Nrf2 (show NFE2L2 Antibodies) transcription factors and redox-induced CRYAB expression in muscle cells.
CryAB protects decidualization against stress conditions.
TNF-alpha (show TNF Antibodies)-induced endothelial adhesion molecule (show NCAM1 Antibodies) expression is reduced in inflamed vessels of alphaB-crystallin deficient mice, and leukocyte rolling velocity and IkappaB levels are increased.
Study shows that overexpression of Bcl-2 (show BCL2 Antibodies) is sufficient to reduce the levels and overall architecture of protein deposition in the transgenic CryABR120G/Bcl-2 (show BCL2 Antibodies) hearts.
alphaB-crystallin is over-expressed in fibrotic lung tissue and favors TGF-beta1 (show TGFB1 Antibodies) pathway via its role in modulating the cellular localization of Smad4 (show SMAD4 Antibodies).
Data suggest that Cryab plays role in embryo implantation/decidualization; on day 5 of pregnancy when embryo implantation takes place, high level of Cryab mRNA is expressed in subluminal stroma surrounding the implanting blastocyst.
Alpha B-crystallin inhibits caspase 3 activation in cells primed for apoptosis by retinoblastoma protein inactivation.
The alphaB-crystallin content of bovine type I muscle fibers is quantitatively similar to that in the predominantly type I fibers of rat soleus muscle.
In the presence of alpha-crystallin or GroEL (show GroEL Antibodies) the kinetic of GAPDH (show GAPDH Antibodies) aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation.
one of the functions of alphaB-crystallin is to bind microtubules via microtubule binding proteins and to give the MTs (show NEU2 Antibodies) resistance to disassembly
The study provides evidence for the regulation of the chaperone activity of alphaB-crystallin by phosphorylation and indicates that this may play an important role in alleviating the pathogenic effects associated with protein conformational diseases.
Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families\; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone\; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits\; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed\; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases\; a missense mutation cosegregated in a family with a desmin-related myopathy.
crystallin, alpha B
, alpha-crystallin B chain
, hypothetical protein
, heat shock protein beta-5
, heat-shock 20 kD like-protein
, renal carcinoma antigen NY-REN-27
, rosenthal fiber component
, alpha B-crystallin
, crystallin, alpha 2
, crystallin, alpha polypeptide 2
, Crystallin, alpha polypeptide 2
, Alpha-crystallin B chain
, alpha B crystallin