anti-Crystallin, alpha B (CRYAB) Antibodies

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. Additionally we are shipping CRYAB Kits (47) and CRYAB Proteins (36) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CRYAB 1410 P02511
CRYAB 12955 P23927
CRYAB 25420 P23928
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-CRYAB Antibodies at antibodies-online.com

Showing 10 out of 470 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of CRYAB (arrow) using rabbit polyclonal CRYAB Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CRYAB gene. CRYAB Antibody (Center)  western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the CRYAB antibody detected the CRYAB protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HepG2 cells treated with nocodazole 1ug/ml 16h, using CRYAB (Phospho-Ser19) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human skeletal muscle, using CRYAB (Phospho-Ser19) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from COS7 cells treated with anisomycin 25ug/ml 30', using CRYAB (Phospho-Ser45) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human heart, using CRYAB (Phospho-Ser45) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human skeletal muscle, using CRYAB/Crystallin-alpha-B (Phospho-Ser59) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Cow Mouse Un-conjugated ELISA, ICC, IF, WB Alpha B Crystallin (1A7 D5), AlphaA (L), AlphaB (R). 50 μg Log in to see 2 to 3 Days
$202.40
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from 293 cells, using CRYAB (Ab-19) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using CRYAB (Ab-19) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human heart tissue, using CRYAB/Crystallin-alpha-B (Ab-45) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated ELISA, WB ABIN238599 (0.01µg/ml) staining of mouse eye lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Human Mouse Un-conjugated WB CRYAB monoclonal antibody (M01), clone 1A10-1A4 Western Blot analysis of CRYAB expression in C32. Detection limit for recombinant GST tagged CRYAB is approximately 1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated WB 400 μL Log in to see 10 to 11 Days
$324.50
Details

CRYAB Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
, ,
,
, , , , , , , , , , , , , , , , , , ,
Mouse (Murine) , , , ,
, , ,
,
, , , , , , , , , , , , , , , , , , ,
Rat (Rattus) , , , ,
, ,
,
, , , , , , , , , , , , , , , , , , ,

Top referenced anti-CRYAB Antibodies

  1. Cow (Bovine) Monoclonal CRYAB Primary Antibody for ELISA, ICC - ABIN361808 : Bullard, Ferguson, Minajeva, Leake, Gautel, Labeit, Ding, Labeit, Horwitz, Leonard, Linke: Association of the chaperone alphaB-crystallin with titin in heart muscle. in The Journal of biological chemistry 2004 (PubMed)
    Show all 13 references for 361808

  2. Human Monoclonal CRYAB Primary Antibody for WB - ABIN393435 : Kida, Wierzba-Bobrowicz, Palminiello, Kaur, Jarzabek, Walus, Albertini, Golabek: Molecular chaperone alphaB-crystallin is expressed in the human fetal telencephalon at midgestation by a subset of progenitor cells. in Journal of neuropathology and experimental neurology 2010 (PubMed)
    Show all 5 references for 393435

  3. Human Monoclonal CRYAB Primary Antibody for WB - ABIN1944889 : Kramps, de Man, de Jong: The primary structure of the B2 chain of human alpha-crystallin. in FEBS letters 1977 (PubMed)
    Show all 4 references for 1944889

  4. Human Polyclonal CRYAB Primary Antibody for IHC, ELISA - ABIN1532588 : Dubin, Ally, Chung, Piatigorsky: Human alpha B-crystallin gene and preferential promoter function in lens. in Genomics 1990 (PubMed)
    Show all 2 references for 1532588

  5. Human Polyclonal CRYAB Primary Antibody for IHC, ELISA - ABIN1531572 : Kovalyov, Shishkin, Efimochkin, Kovalyova, Ershova, Egorov, Musalyamov: The major protein expression profile and two-dimensional protein database of human heart. in Electrophoresis 1996 (PubMed)
    Show all 2 references for 1531572

  6. Human Polyclonal CRYAB Primary Antibody for ELISA, WB - ABIN238599 : Ousman, Tomooka, van Noort, Wawrousek, OConnor, Hafler, Sobel, Robinson, Steinman: Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. in Nature 2007 (PubMed)

  7. Human Polyclonal CRYAB Primary Antibody for IHC (p), WB - ABIN657620 : Martins-de-Souza, Schmitt, Röder, Lebar, Schneider-Axmann, Falkai, Turck: Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia. in Journal of psychiatric research 2010 (PubMed)

More Antibodies against CRYAB Interaction Partners

Pig (Porcine) Crystallin, alpha B (CRYAB) interaction partners

  1. This study clearly demonstrated that both the length and electrostatic charge of the COOH-terminal segment play crucial roles in governing the structural stability and chaperone activity of alphaB-crystallin.

Human Crystallin, alpha B (CRYAB) interaction partners

  1. Results demonstrated that CRYAA (show CRYAA Antibodies) rs7278468 and CRYAB rs370803064/rs387907338 are correlated with the risk and clinicopathological features of children suffering from congenital cataract.

  2. A missense mutation in alpha B-crystallin that changes proline 20 to an arginine leads to diminished anti-apoptotic activity compared with the native protein.

  3. phosphorylation finely regulates the chaperone activity of CRYAB with multipass TMPs and suggest a pivotal role for S59 in this process

  4. A missense mutation (p.D109G) in CRYAB causes restrictive cardiomyopathy (RCM (show Unc5c Antibodies)).

  5. This work examines the molecular mechanism by which two canonical sHsps, alphaB-crystallin (alphaB-c) and Hsp27 (show HSPB1 Antibodies), interact with aggregation-prone alpha-syn to prevent its aggregation in vitro Both sHsps are very effective inhibitors of alpha-syn aggregation

  6. 343delT/343delT and WT KI/343delT-induced pluripotent stem cell-derived skeletal myotubes and cardiomyocytes did not express detectable levels of 343delT protein, contributable to the extreme insolubility of the mutant protein. Overexpression of HSPB5 343delT resulted in insoluble mutant protein aggregates and induction of a cellular stress response.

  7. Study suggests that wild-type and mutant alphaB-Cry (show CRY2 Antibodies) have dissimilar secondary and tertiary structures. Moreover, alphaB-Cry (show CRY2 Antibodies) indicates slightly improved chaperone activity upon the R12C mutation. These results may explain to some extent the non-cataractogenic nature of R12C mutation in aB-Cry (show CRY2 Antibodies).

  8. Cryab expression was elevated in osteosarcoma tissues and cell lines, and down-regulation of Cryab in MG-63 and U-2OS cells led to a decline in the cells' aggressiveness, and reduced secretion of matrix metalloproteinase-9 (show MMP9 Antibodies) in vitro, and lower metastasis potential in vivo.

  9. Identifies alphaB-crystallin as a new binding partner for Nav1.5 (show SCN5A Antibodies). alphaB-Crystallin interacts with Nav1.5 (show SCN5A Antibodies) and increases INa (show INA Antibodies) by modulating the expression level and internalization of cell surface Nav1.5 (show SCN5A Antibodies) and ubiquitination of Nav1.5 (show SCN5A Antibodies), which requires the protein-protein interactions between alphaB-crystallin and Nav1.5 (show SCN5A Antibodies) and between alphaB-crystallin and functionally active Nedd4-2 (show NEDD4L Antibodies).

  10. alphaB-crystallin is an important regulator of epithelial-mesenchymal transition, acting as a molecular chaperone (show HSP90AA1 Antibodies) for SMAD4 (show SMAD4 Antibodies) and as its potential therapeutic target for preventing subretinal fibrosis development in neovascular age-related macular degeneration

Mouse (Murine) Crystallin, alpha B (CRYAB) interaction partners

  1. desmin and alphaBeta-crystallin are localized at sarcoplasmic reticulum (SR)-mitochondria-associated membranes (MAMs), where they interact with VDAC, Mic60 - the core component of mitochondrial contact site and cristae organizing system (MICOS) complex - and ATP synthase, suggesting that these associations could be crucial in mitoprotection at different levels.

  2. This study demonstrated that HspB5 mRNA localization in myelin-enriched white and gray matter

  3. alphaB-crystallin is an important regulator of epithelial-mesenchymal transition, acting as a molecular chaperone (show HSP90AA1 Antibodies) for SMAD4 (show SMAD4 Antibodies) and as its potential therapeutic target for preventing subretinal fibrosis development in neovascular age-related macular degeneration

  4. It is a non-Hsp gene, which is essential for HSF1 (show HSF1 Antibodies)-mediated maintenance of whole body homeostasis.

  5. A previously unrecognized link between c-Jun (show JUN Antibodies) and Nrf2 (show NFE2L2 Antibodies) transcription factors and redox-induced CRYAB expression in muscle cells.

  6. CryAB protects decidualization against stress conditions.

  7. TNF-alpha (show TNF Antibodies)-induced endothelial adhesion molecule (show NCAM1 Antibodies) expression is reduced in inflamed vessels of alphaB-crystallin deficient mice, and leukocyte rolling velocity and IkappaB levels are increased.

  8. Study shows that overexpression of Bcl-2 (show BCL2 Antibodies) is sufficient to reduce the levels and overall architecture of protein deposition in the transgenic CryABR120G/Bcl-2 (show BCL2 Antibodies) hearts.

  9. alphaB-crystallin is over-expressed in fibrotic lung tissue and favors TGF-beta1 (show TGFB1 Antibodies) pathway via its role in modulating the cellular localization of Smad4 (show SMAD4 Antibodies).

  10. Data suggest that Cryab plays role in embryo implantation/decidualization; on day 5 of pregnancy when embryo implantation takes place, high level of Cryab mRNA is expressed in subluminal stroma surrounding the implanting blastocyst.

Cow (Bovine) Crystallin, alpha B (CRYAB) interaction partners

  1. The alphaB-crystallin content of bovine type I muscle fibers is quantitatively similar to that in the predominantly type I fibers of rat soleus muscle.

  2. In the presence of alpha-crystallin or GroEL (show GroEL Antibodies) the kinetic of GAPDH (show GAPDH Antibodies) aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation.

  3. one of the functions of alphaB-crystallin is to bind microtubules via microtubule binding proteins and to give the MTs (show NEU2 Antibodies) resistance to disassembly

  4. The study provides evidence for the regulation of the chaperone activity of alphaB-crystallin by phosphorylation and indicates that this may play an important role in alleviating the pathogenic effects associated with protein conformational diseases.

CRYAB Antigen Profile

Protein Summary

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families\; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone\; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits\; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed\; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases\; a missense mutation cosegregated in a family with a desmin-related myopathy.

Gene names and symbols associated with CRYAB

  • crystallin, alpha B (CRYAB) antibody
  • hypothetical protein (alpha-B-crystallin) antibody
  • crystallin, alpha B (Cryab) antibody
  • AACRYA antibody
  • CMD1II antibody
  • Crya-2 antibody
  • Crya2 antibody
  • CRYAB antibody
  • CTPP2 antibody
  • CTRCT16 antibody
  • HspB5 antibody
  • MFM2 antibody

Protein level used designations for CRYAB

crystallin, alpha B , alpha-crystallin B chain , hypothetical protein , heat shock protein beta-5 , heat-shock 20 kD like-protein , renal carcinoma antigen NY-REN-27 , rosenthal fiber component , P23 , alpha B-crystallin , alpha(B)-crystallin , crystallin, alpha 2 , crystallin, alpha polypeptide 2 , Crystallin, alpha polypeptide 2 , Alpha(B)-crystallin , Alpha-crystallin B chain , alpha B crystallin , alpha-B-crystallin , alphaB-crystallin

GENE ID SPECIES
451543 Pan troglodytes
710747 Macaca mulatta
791109 Ornithorhynchus anatinus
100127443 Sus scrofa
191528 Caenorhabditis elegans
1410 Homo sapiens
12955 Mus musculus
281719 Bos taurus
25420 Rattus norvegicus
396089 Gallus gallus
100519789 Sus scrofa
497274 Ovis aries
100009295 Oryctolagus cuniculus
100306972 Cavia porcellus
479441 Canis lupus familiaris
101827485 Mesocricetus auratus
100172850 Pongo abelii
Selected quality suppliers for anti-CRYAB (CRYAB) Antibodies
Did you look for something else?