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Cullin 3 Proteins (CUL3)

CUL3 encodes a member of the cullin protein family. Additionally we are shipping Cullin 3 Antibodies (91) and Cullin 3 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CUL3 8452 Q13618
CUL3 26554 Q9JLV5
CUL3 301555  
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Top Cullin 3 Proteins at

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

CUL3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Cullin 3 (CUL3) Interaction Partners

Arabidopsis thaliana Cullin 3 (CUL3) interaction partners

  1. Data show that CUL3 and BPM proteins assemble in planta with WRI1.

  2. The plasma membrane-associated phototropic receptor phot1 is ubiquitinated in response to blue light activation. Ubiquitination of phot1 is dependent upon both the phot1-interacting proteins NPH3 and CUL3.

  3. AtCUL3a and AtCUL3b can assemble in Arabidopsis with BTB/POZ-MATH and AtRBX1 proteins to form functional E3 ligases. [AtCUL3a]

  4. CUL3A is ubiquitously expressed in plants and is able to interact with the ring-finger protein (show TRIM31 Proteins) RBX1 (show RBX1 Proteins). [CUL3A]

  5. Arabidopsis CUL3A gene is essential for normal embryogenesis.

  6. work highlights that CUL3 is essential for the normal division and organisation of the root stem cell niche and columella root cap cells

  7. CUL3a and CUL3b are essential for plant development [CUL3a]

Human Cullin 3 (CUL3) interaction partners

  1. CUL3 acts as a tumor suppressor by regulating oxidative stress

  2. The authors find that the KCTD proteins 5, 6, 9 and 17 bind to Cul3 with high affinity, while the KCTD proteins 1 and 16 do not have detectable binding.

  3. Study identifies a key role of Cul3-KLHL20 (show KLHL20 Proteins) in autophagy termination by controlling autophagy-dependent turnover of ULK1 (show ULK1 Proteins) and VPS34 (show PIK3C3 Proteins) complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism.

  4. Data show that the differentiation of LiSa-2 preadipocytes is associated with an increase of cullin-associated and neddylation-dissociated 1 (CAND1 (show CAND1 Proteins)), COP9 (show COPS8 Proteins) signalosome (CSN), neddylated cullin 3 (Cul3) and the BTB protein Keap1 (show KEAP1 Proteins).

  5. Heterodimeric CUL3 proteinubiquitylates TIAM1.CUL3 regulates TIAM1 abundance and subsequent RAC1 signaling.

  6. these findings indicate that the designed stapled peptides can efficiently mimic protein-protein interactions and are potentially able to modulate fundamental biological processes involving Cul3.

  7. these results suggest an essential role for CUL3 in the invasion and migration of trophoblast cells, and dysregulation of its expression may be associated with the onset of pre-eclampsia

  8. The KCTD5/cullin3 complex stabilizes ZNF711 transcription factor.Formation of trimeric complexes of KCTD5/cullin3 with MCM7, ZNF711 and FAM193B.

  9. Cul3 deletion mutations (associated with hypertension), impair ubiquitin ligase activity toward RhoA (show RHOA Proteins).

  10. Studied the DNA-level mechanisms affecting KEAP1 (show KEAP1 Proteins)/CUL3/RBX1 E3-ubiquitin ligase (show MUL1 Proteins) complex as a regulator of NRF2 (show GABPA Proteins) levels in ovarian cancer.

Mouse (Murine) Cullin 3 (CUL3) interaction partners

  1. Suggest that the hyperkalemia in knock-in mouse with the CUL3(Delta403-459) mutation is not caused by reduced ROMK (show KCNJ1 Proteins) expression in the distal nephron.

  2. Study identifies a key role of Cul3-KLHL20 (show KLHL20 Proteins) in autophagy termination by controlling autophagy-dependent turnover of ULK1 (show ULK1 Proteins) and VPS34 (show PIK3C3 Proteins) complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism.

  3. These results suggest that KLHL2 (show KLHL2 Proteins) likely plays a role in the pathogenesis of FHHt, and aggravates the phenotype caused by mutations in CUL3 and WNK4 (show WNK4 Proteins).

  4. Hypoxia-responsive miR (show MLXIP Proteins)-101 stimulates angiogenesis by activating the HO-1 (show HMOX1 Proteins)/VEGF (show VEGFA Proteins)/eNOS (show NOS3 Proteins) axis via Cul3 targeting

  5. Mutation of cul3 protein is involved in the development of renal hypertension and chronic kidney diseases.

  6. Data show that Bcl6 (show BCL6 Proteins) (B cell lymphoma 6)-cullin 3 complexes provide essential negative feedback regulation during both thymocyte development and T cell activation to restrain excessive T follicular helper (Tfh) responses.

  7. the early or pre-induction nuclear export of INrf2 (show KEAP1 Proteins) in response to antioxidants is controlled by tyrosine phosphorylation, whereas the nuclear export of Cul3 and Rbx1 is controlled by INrf2 (show KEAP1 Proteins), allowing normal activation or repression of Nrf2 (show NFE2L2 Proteins)

  8. Knockdown of Cullin-3 or inhibition of cullin-RING ligase activity in aortic smooth muscle cells increased RhoA (show RHOA Proteins).

  9. CUL3 deletion in mice demonstrated an essential role for CUL3 in the development of PLZF (show ZBTB16 Proteins)- and BCL6 (show BCL6 Proteins)-dependent lineages; distinct lineage-specific BTB-ZF transcription factors recruit CUL3 to alter the ubiquitination pattern of their associated chromatin-modifying complex

  10. The authors identified MUF1 as the first substrate for RhoBTB-Cul3 ubiquitin ligase complexes.

Caenorhabditis elegans (C. elegans) Cullin 3 (CUL3) interaction partners

  1. KEL-8 is a substrate receptor for Cullin 3 ubiquitin ligases that is required for the proteolysis of GLR-1 receptors and suggest a novel postmitotic role in neurons for Kelch/CUL3 ubiquitin ligases.

  2. The BTB-containing protein MEL-26 is a component required for degradation of MEI-1 (show MEI1 Proteins) in vivo; importantly, MEL-26 specifically interacts with CUL-3 and MEI-1 (show MEI1 Proteins) in vivo and in vitro, and displays properties of a substrate-specific adaptor

  3. the identification of a large family of BTB-domain proteins as substrate-specific adaptors for C. elegans CUL-3

  4. FIGL-1 by the CUL-3MEL-26 E3 ligase spatially restricts FIGL-1 function to mitotic cells, where it is required for correct progression through mitosis.

  5. cullin (CUL)-3 as a component of E3 ligase and KEL-8 as the substrate adaptor of RPY-1.

Cullin 3 (CUL3) Protein Profile

Protein Summary

This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with Cullin 3 Proteins (CUL3)

  • cullin 3 (CUL3)
  • cullin 3 (cul3)
  • cullin 3 (cul3-a)
  • cullin 3 (cul3-b)
  • cullin-3 (PTRG_11586)
  • Cullin-3 (CUL-3) (Smp_117580)
  • cullin 3a (cul3a)
  • cullin 3 (Cul3)
  • Protein CUL-3 (cul-3)
  • AI467304 protein
  • ATCUL3 protein
  • ATCUL3A protein
  • AW146203 protein
  • CUL-3 protein
  • CUL-3-A protein
  • CUL-3-B protein
  • CUL3 protein
  • CUL3A protein
  • cul3b protein
  • Cullin-3 protein
  • Cullin-3-A protein
  • Cullin-3-B protein
  • cullin 3 protein
  • cullin 3A protein
  • mKIAA0617 protein
  • PHA2E protein
  • T24P13.25 protein
  • wu:fc37e01 protein

Protein level used designations for Cullin 3 Proteins (CUL3)

cullin-3 , cullin-3-A , cullin-3-B , Cullin-3 (CUL-3) , cullin 3 , CUL-3

100061420 Equus caballus
548729 Xenopus (Silurana) tropicalis
446487 Xenopus laevis
444103 Xenopus laevis
6349903 Pyrenophora tritici-repentis Pt-1C-BFP
8349090 Schistosoma mansoni
324655 Danio rerio
744812 Pan troglodytes
839226 Arabidopsis thaliana
8452 Homo sapiens
26554 Mus musculus
301555 Rattus norvegicus
424804 Gallus gallus
477392 Canis lupus familiaris
534325 Bos taurus
178547 Caenorhabditis elegans
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