Cullin 4A Proteins (CUL4A)

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009].. Additionally we are shipping Cullin 4A Antibodies (76) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CUL4A 8451 Q13619
CUL4A 99375 Q3TCH7
Rat CUL4A CUL4A 361181  
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Top Cullin 4A Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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CUL4A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Cullin 4A (CUL4A) Interaction Partners

Zebrafish Cullin 4A (CUL4A) interaction partners

  1. Results show that cul4a but not cul4b (show CUL4B Proteins) is required for the expression of tbx5a, an essential transcription factor in heart and limb development.

Human Cullin 4A (CUL4A) interaction partners

  1. knockdown of cullin 4A via small interfering RNA inhibited the proliferation of the multiple myeloma cell lines by delaying cell-cycle progression and increasing apoptosis. cullin 4A downregulation inhibited multiple myeloma cell migration and invasion in vitro. Our results suggested that cullin 4A could be a promising therapy target in multiple myeloma patients

  2. findings revealed that CUL4A and CUL4B (show CUL4B Proteins) are differentially associated with etiologic factors for pulmonary malignancies and are independent prognostic markers for the survival of distinct lung cancer subtypes

  3. decreased tumour growth and increased chemosensitivity to gemcitabine were also noted after Cul4A knockdown.

  4. CUL4A played an oncogene (show RAB1A Proteins) role through ZEB1 in IL-6 (show IL6 Proteins)-induced colorectal carcinoma progression.

  5. Overexpression of miR (show MLXIP Proteins)-494 inhibited proliferation, migration, invasion and EMT (show ITK Proteins) of ovarian cancer cells by directly suppressing CUL4A expression. Therefore, our findings indicate that miR (show MLXIP Proteins)-494/CUL4A axis is important in the control of ovarian cancer tumorigenesis.

  6. CUL4A sensitizes colorectal cancer cells to cisplatin induced cell death.

  7. Elevated expression of CUL4A is positively correlated with distant metastases.

  8. Increased CUL4A expression is associated with osteosarcoma.

  9. Findings indicate the importance of a microRNAs miR (show MLXIP Proteins)-9/137-CUL4A-Hippo signaling axis in gastric cancer (GC), and suggest new therapeutic targets for future treatment of GC.

  10. CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.

Mouse (Murine) Cullin 4A (CUL4A) interaction partners

  1. These studies identify CUL4-DDB1 (show DDB1 PLURAL_@36464@) complex as a novel post-translational regulator of stem and progenitor maintenance and differentiation.

  2. CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.

  3. Findings indicate that Cul4A is oncogenic in vivo and that Cul4A over-expression is associated with cisplatin resistance in lung cancer cells.

  4. this study revealed an indispensable role for Cul4a during male germ cell meiosis.

  5. The primary spermatocytes in Cul4A-/- mice are deficient in progression through late prophase I, a time point when expression of the X-linked Cul4B (show CUL4B Proteins) gene is silenced due to meiotic sex chromosome inactivation.

  6. CUL-4A is critical for early embryonic development. CUL-4A(-/-) embryos die between 4.5 and 7.5 dpc.

  7. Enforced CUL-4A expression does not alter the cell cycle distribution of uninduced cells. It increases the proportion of induced cells in S-phase & reduces the proportion in G0/G1. This CUL-4A regulatory function is interconnected with differentiation.

  8. a Cul4A ubiquitin ligase (show RNF123 Proteins) positively regulates proliferation by targeting p27 (show CDKN1B Proteins) for degradation and that Cul4A down-regulation during terminal erythroid differentiation allows p27 (show CDKN1B Proteins) to accumulate and signal cell cycle exit

  9. Cul4A(+/-) hematopoietic stem-cells exhibit defects in engraftment and self-renewal capacity

  10. Cul4A deficiency resulted in DNA damage and apoptosis of rapidly dividing cells, and mutant mice died within 3 to 10 days after induction with dramatic atrophy of the intestinal villi, bone marrow, and spleen, and with hematopoietic failure

Cullin 4A (CUL4A) Protein Profile

Protein Summary

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009

Gene names and symbols associated with Cullin 4A Proteins (CUL4A)

  • cullin 4A (CUL4A)
  • cullin 4A (cul4a)
  • cullin 4A (Cul4a)
  • 2810470J21Rik protein
  • AW495282 protein
  • CUL4A protein
  • RGD1563853 protein
  • zgc:64071 protein

Protein level used designations for Cullin 4A Proteins (CUL4A)

cullin 4A , cullin-4A-like , CUL-4A , cullin-4A

GENE ID SPECIES
100033930 Equus caballus
394002 Danio rerio
452694 Pan troglodytes
548647 Xenopus (Silurana) tropicalis
607683 Canis lupus familiaris
100411111 Callithrix jacchus
100453992 Pongo abelii
100470988 Ailuropoda melanoleuca
100549149 Meleagris gallopavo
100579811 Nomascus leucogenys
8451 Homo sapiens
99375 Mus musculus
361181 Rattus norvegicus
418744 Gallus gallus
100517912 Sus scrofa
617935 Bos taurus
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