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Cullin 4B Proteins (CUL4B)

CUL4B is a member of the cullin family. Additionally we are shipping Cullin 4B Antibodies (87) and Cullin 4B Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CUL4B 8450 Q13620
CUL4B 72584 A2A432
Rat CUL4B CUL4B 302502  
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Top Cullin 4B Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CUL4B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Cullin 4B (CUL4B) Interaction Partners

Zebrafish Cullin 4B (CUL4B) interaction partners

  1. Results show that cul4a (show CUL4A Proteins) but not cul4b is required for the expression of tbx5a, an essential transcription factor in heart and limb development.

Human Cullin 4B (CUL4B) interaction partners

  1. these results showed that knockdown of CUL4B inhibit proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway

  2. Our data are consistent with the idea that the CUL4A (show CUL4A Proteins)/B-DDB1 (show DDB1 Proteins)-CRBN (show CRBN Proteins) complex catalyses the polyubiquitination and thus controls the degradation of CLC-1 (show CLCN1 Proteins) channels.

  3. FBXO44 (show FBXO44 Proteins)-mediated degradation of RGS2 (show RGS2 Proteins) protein uniquely depends on a Cul4B/DDB1 (show DDB1 Proteins) complex.

  4. results established a critical role of CUL4B in negatively regulating the p53 (show TP53 Proteins)-ROS (show ROS1 Proteins) positive feedback loop that drives cellular senescence

  5. Results demonstrated that CUL4B promotes cell proliferation and inhibits the apoptosis of osteosarcoma cells.

  6. Results show that CUL4A (show CUL4A Proteins)- and CUL4B-mediated polyubiquitination of gamma-tubulin (show TUBG1 Proteins) for its degradation.

  7. Data show that CUL4B variants are associated with a wide range of cerebral malformations and suggest an important role in brain through its interaction with WDR62, a protein in which variants were identified in patients with cerebral malformations.

  8. Cullin4B-Ring E3 ligase complex (CRL4B) is physically associated with PRC2. CRL4B possesses an intrinsic transcription repressive activity by promoting H2AK119 monoubiquitination. CUL4B promotes cancer cell proliferation, invasion, and tumorigenesis in vitro and in vivo.

  9. CUL4B can up-regulate Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signalling in human HCC (show FAM126A Proteins) through transcriptionally repressing Wnt (show WNT2 Proteins) antagonists and thus contributes to the malignancy of HCC (show FAM126A Proteins).

  10. The intellectual disability phenotype is caused by aberrant splicing and removal of intron 7 from CUL4B gene primary transcript.

Mouse (Murine) Cullin 4B (CUL4B) interaction partners

  1. CUL4B links two distinct spermatogenetic processes to a single E3 ligase, highlighting the significance of ubiquitin modification during spermatogenesis.

  2. results demonstrate a critical role of CUL4B in hepatocarcinogenesis in mice

  3. Ptgds (show PTGDS Proteins) is targeted and repressed by the CUL4B/PRC2 complex.

  4. FBXO44 (show FBXO44 Proteins)-mediated degradation of RGS2 (show RGS2 Proteins) protein uniquely depends on a Cul4B/DDB1 (show DDB1 Proteins) complex.

  5. CUL4B knockdown alleviated in vivo tumorigenesis in glioma xenograft nude mice.

  6. Data indicate a role of cullin family, CUL4B, in the immune system.

  7. Data indicate that in Cul4b-deficient embryonic fibroblasts showed Jab1 (show COPS5 Proteins) accumulation.

  8. Cul4b mutant mouse showed decrease in the number of parvalbumin (show PVALB Proteins)-positive neurons and altered dendritic properties.

  9. Epiblast-specific deletion of Cul4b prevented embryonic lethality and gave rise to viable Cul4b null mice.

  10. Cul4b is essential for the development of extra-embryonic tissues, but is dispensable for embryogenesis itself.

Cullin 4B (CUL4B) Protein Profile

Protein Summary

This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Cullin 4B Proteins (CUL4B)

  • cullin 4B (CUL4B)
  • cullin 4B (cul4b)
  • cullin 4B (Tb927.3.1290)
  • cullin 4B (Cul4b)
  • 2700050M05Rik protein
  • AA409770 protein
  • CUL-4B protein
  • im:7140950 protein
  • im:7150765 protein
  • MGC115611 protein
  • mKIAA0695 protein
  • MRXHF2 protein
  • MRXS15 protein
  • MRXSC protein
  • RGD1564494 protein
  • SFM2 protein
  • Tb03.1J15.620 protein

Protein level used designations for Cullin 4B Proteins (CUL4B)

cullin 4B , cullin-4B , cullin-4B-like , CUL-4B

GENE ID SPECIES
492102 Canis lupus familiaris
539668 Bos taurus
696410 Macaca mulatta
735163 Xenopus laevis
3656065 Trypanosoma brucei brucei strain 927/4 GUTat10.1
100033938 Equus caballus
100079138 Ornithorhynchus anatinus
100151714 Xenopus (Silurana) tropicalis
100194954 Salmo salar
100351102 Oryctolagus cuniculus
100394843 Callithrix jacchus
100475326 Ailuropoda melanoleuca
100542698 Meleagris gallopavo
100564485 Anolis carolinensis
100592746 Nomascus leucogenys
560313 Danio rerio
8450 Homo sapiens
72584 Mus musculus
302502 Rattus norvegicus
422364 Gallus gallus
100513454 Sus scrofa
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