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anti-Cullin-Associated and Neddylation-Dissociated 1 (CAND1) Antibodies

Enhances transcription from various types of promoters. Additionally we are shipping CAND1 Kits (5) and CAND1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CAND1 71902 Q6ZQ38
CAND1 55832 Q86VP6
CAND1 117152 P97536
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Top anti-CAND1 Antibodies at antibodies-online.com

Showing 10 out of 34 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CAND1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, IP, WB Conjugation pathways for ubiquitin and ubiquitin-like modifiers (UBLs). Most modifiers mature by proteolytic processing from inactive precursors (a, amino acid). Arrowheads point to the cleavage sites. Ubiquitin is expressed either as polyubiquitin or as a fusion with ribosomal proteins. Conjugation requires activating (E1) and conjugating (E2) enzymes that form thiolesters (S) with the modifiers. Modification of cullins by RUB involves SCF(SKP1/cullin-1/F-box protein) /CBC(cullin- 2/elongin B/elonginC) -like E3 enzymes that are also involved in ubiquitination. In contrast to ubiquitin, the UBLs do not seem to form multi-UBL chains. UCRP(ISG15) resembles two ubiquitin moieties linked head-to-tail. Whether HUB1 functions as a modifier is currently unclear. APG12 and URM1 are distinct from the other modifiers because they are unrelated in sequence to ubiquitin. Data contributed by S.Jentsch, see references below. 0.1 mL Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated EIA, IP, WB Conjugation pathways for ubiquitin and ubiquitin-like modifiers (UBLs). Most modifiers mature by proteolytic processing from inactive precursors (a, amino acid). Arrowheads point to the cleavage sites. Ubiquitin is expressed either as polyubiquitin or as a fusion with ribosomal proteins. Conjugation requires activating (E1) and conjugating (E2) enzymes that form thiolesters (S) with the modifiers. Modification of cullins by RUB involves SCF(SKP1/cullin-1/F-box protein) /CBC(cullin- 2/elongin B/elonginC) -like E3 enzymes that are also involved in ubiquitination. In contrast to ubiquitin, the UBLs do not seem to form multi-UBL chains. UCRP(ISG15) resembles two ubiquitin moieties linked head-to-tail. Whether HUB1 functions as a modifier is currently unclear. APG12 and URM1 are distinct from the other modifiers because they are unrelated in sequence to ubiquitin. Data contributed by S.Jentsch, see references below. 0.1 mL Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to CAND1 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to CAND1 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated IHC (p), WB Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$676.50
Details
Dog Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to CAND1 on HeLa cell (antibody concentration 10 µg/mL). CAND1 monoclonal antibody (M01), clone 5D7 Western Blot analysis of CAND1 expression in HeLa NE. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated WB CAND1 monoclonal antibody (M05), clone 1G5. Western Blot analysis of CAND1 expression in Hela NE. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details

CAND1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)


Human , ,
,
,
Rat (Rattus)


Top referenced anti-CAND1 Antibodies

  1. Human Polyclonal CAND1 Primary Antibody for EIA, IP - ABIN117945 : Concejero, Chen, Wang, Wang, Lin, Liu, Yang, Yong, Lin, Jawan, Huang, Cheng, Eng: Living donor liver transplantation for hepatocellular carcinoma: a single-center experience in Taiwan. in Transplantation 2008 (PubMed)
    Show all 9 references for ABIN117945

  2. Human Polyclonal CAND1 Primary Antibody for EIA, IP - ABIN117944 : Kim, Min, Lee, Kim, Oh, Jeon, Lee, Im, Chung, Kim, Kim, Bang, Sung, Kim, Heo: High tumour islet macrophage infiltration correlates with improved patient survival but not with EGFR mutations, gene copy number or protein expression in resected nonsmall cell lung cancer. in British journal of cancer 2008 (PubMed)
    Show all 9 references for ABIN117944

  3. Cow (Bovine) Polyclonal CAND1 Primary Antibody for WB - ABIN2775887 : Min, Kwon, Park, Park, Yoon, Yoon: CAND1 enhances deneddylation of CUL1 by COP9 signalosome. in Biochemical and biophysical research communications 2005 (PubMed)

  4. Human Monoclonal CAND1 Primary Antibody for IF, IHC (p) - ABIN565932 : Korzeniewski, Hohenfellner, Duensing: CAND1 promotes PLK4-mediated centriole overduplication and is frequently disrupted in prostate cancer. in Neoplasia (New York, N.Y.) 2012 (PubMed)

  5. Cow (Bovine) Polyclonal CAND1 Primary Antibody for WB - ABIN2775888 : Min, Hwang, Lee, Park, Tamura, Yoon: TIP120A associates with cullins and modulates ubiquitin ligase activity. in The Journal of biological chemistry 2003 (PubMed)

More Antibodies against CAND1 Interaction Partners

Mouse (Murine) Cullin-Associated and Neddylation-Dissociated 1 (CAND1) interaction partners

  1. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation

Human Cullin-Associated and Neddylation-Dissociated 1 (CAND1) interaction partners

  1. Data show that the differentiation of LiSa-2 preadipocytes is associated with an increase of cullin-associated and neddylation-dissociated 1 (CAND1), COP9 (show COPS8 Antibodies) signalosome (CSN), neddylated cullin 3 (Cul3 (show CUL3 Antibodies)) and the BTB protein Keap1 (show KEAP1 Antibodies).

  2. The Epstein-Barr virus protein BPLF1, is targeted to cullin-RING ubiquitin ligases (CRLs) via the interaction of the conserved helix-2 with helix-23 of cullins, at a site involved in electrostatic interaction with CAND1.

  3. We demonstrate that the accumulation of p27 (show PAK2 Antibodies) is associated with an increase of CAND1 and a decrease of Skp2 during adipogenesis of human LiSa-2 preadipocytes. CAND1 knockdown reduces p27 (show PAK2 Antibodies) and blocks adipogenesis.

  4. Study shows that Cand1 can unambiguously stimulate SCF (show KITLG Antibodies) activity in vitro by enabling an F box protein (show FBXW10 Antibodies)-Skp1 (show SKP1 Antibodies) complex to access Cul1 (show CUL1 Antibodies) that was previously occupied by a different F box protein (show FBXW10 Antibodies)-Skp1 (show SKP1 Antibodies) complex, and that Cand1 promotes assembly in vivo of new F box proteins with pre-existing Cul1 (show CUL1 Antibodies) molecules.

  5. CAND1 promotes PLK4 (show PLK4 Antibodies)-mediated centriole overduplication and is frequently disrupted in prostate cancer.

  6. COMMD1 (show COMMD1 Antibodies) (copper metabolism MURR1 (show COMMD1 Antibodies) domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.

  7. CAND1 does not function by sequestering cullins in vivo to prevent substrate receptor autoubiquitination and is likely to regulate cullin RING ligase activity via alternative mechanisms

  8. miR (show MLXIP Antibodies)-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression.

  9. selectively binds to unneddylated CUL1 (show CUL1 Antibodies) and is dissociated by CUL1 (show CUL1 Antibodies) neddylation

  10. binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex

Arabidopsis thaliana Cullin-Associated and Neddylation-Dissociated 1 (CAND1) interaction partners

  1. HVE/CAND1 gene acts upstream of ATHB-8 at least in higher order veins, in a pathway that involves AXR1, but not LOP1, PIN1, CVP1 or CVP2.

  2. The disruption of the CAND1-CUL1 interaction results in an increased abundance of assembled SCF(TIR1) complex; stabilization of the CAND1-CUL1 interaction diminishes SCF(TIR1) complex abundance.

CAND1 Antigen Profile

Protein Summary

Enhances transcription from various types of promoters. Regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. Prevents neddylation of CUL1 by physically blocking access to the neddylation site. Disrupts interactions between CUL1 and SKP1 and between CUL1 and F-box proteins (By similarity).

Gene names and symbols associated with CAND1

  • cullin-associated and neddylation-dissociated 1 (CAND1) antibody
  • cullin-associated and neddylation-dissociated 1 (cand1) antibody
  • cullin associated and neddylation disassociated 1 (Cand1) antibody
  • cullin-associated and neddylation-dissociated 1 (Cand1) antibody
  • cullin-associated NEDD8-dissociated protein 1 (CAND1) antibody
  • 2310038O07Rik antibody
  • 6330512O03Rik antibody
  • AI195005 antibody
  • AI846556 antibody
  • ATCAND1 antibody
  • cand2 antibody
  • cullin-associated and neddylation dissociated antibody
  • CULLIN-ASSOCIATED AND NEDDYLATION DISSOCIATED 1 antibody
  • D10Ertd516e antibody
  • ETA2 antibody
  • fb78a05 antibody
  • HEMIVENATA antibody
  • HVE antibody
  • mKIAA0829 antibody
  • T8K22.14 antibody
  • T8K22_14 antibody
  • Tip120 antibody
  • Tip120A antibody
  • Tp120a antibody
  • wu:fb78a05 antibody
  • zgc:55729 antibody

Protein level used designations for CAND1

cullin-associated and neddylation-dissociated 1 , cullin-associated and neddylation-dissociated 2 (putative) , TIP120 protein , cullin-associated NEDD8-dissociated protein 1 , cullin-associated and neddylation-dissociated protein 1 , p120 CAND1 , cullin-associated NEDD8-dissociated protein 1-like , TBP-interacting protein , TBP interacting protein , TBP-interacting protein 120A , TBP-interacting protein of 120 kDa A , TBP-interacting protein TIP120A , cullin associated and neddylation disassociated 1

GENE ID SPECIES
417837 Gallus gallus
447973 Xenopus (Silurana) tropicalis
452060 Pan troglodytes
100159824 Acyrthosiphon pisum
100173509 Pongo abelii
100177977 Ciona intestinalis
100202560 Hydra magnipapillata
100347974 Oryctolagus cuniculus
100386203 Callithrix jacchus
100485277 Xenopus (Silurana) tropicalis
100543082 Meleagris gallopavo
71902 Mus musculus
55832 Homo sapiens
117152 Rattus norvegicus
443799 Xenopus laevis
406806 Danio rerio
474437 Canis lupus familiaris
538086 Bos taurus
814786 Arabidopsis thaliana
Selected quality suppliers for anti-CAND1 (CAND1) Antibodies
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