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Cyclic Nucleotide Gated Channel beta 1 Proteins (CNGB1)

Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. Additionally we are shipping GARP Antibodies (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CNGB1 1258 Q14028
Mouse CNGB1 CNGB1 333329  
Rat CNGB1 CNGB1 83686  
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Top GARP Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CNGB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Cyclic Nucleotide Gated Channel beta 1 (CNGB1) Interaction Partners

Cow (Bovine) Cyclic Nucleotide Gated Channel beta 1 (CNGB1) interaction partners

  1. Three CNGA1 (show CNGA1 Proteins) subunits and a single CNGB1 subunit form the rod cyclic nucleotide-gated ion channels.

  2. Glutamic acid-rich proteins could provide the environment needed for protein interactions in the rim (show RBBP8 Proteins) region of optic discs.

  3. Results suggest a novel role for glutamic acid-rich protein-2 as a regulator of spontaneous activation of rod photoreceptor phosphodiesterase, allowing rods to operate at the single photon detection limit.

Human Cyclic Nucleotide Gated Channel beta 1 (CNGB1) interaction partners

  1. Helios (show ZNFN1A2 Proteins), and not FoxP3 (show FOXP3 Proteins), is the marker of activated Tregs expressing GARP/LAP, and FoxP3 (show FOXP3 Proteins)+Helios (show ZNFN1A2 Proteins)+ Tregs have more suppressive characteristics, compared with FoxP3 (show FOXP3 Proteins)+Helios (show ZNFN1A2 Proteins)- Tregs.

  2. GARP2 expression in cones can be detrimental to cones. RDS (show PRPH2 Proteins)/GARP interactions remain under investigation but are critical for both OS structure and function.

  3. Deletion of the cyclic nucleotide gated channel CNGB1 alters response waveform but leaves light adaptation intact in a transgenic model.

  4. When expressed in a heterologous expression system the corresponding mutant full-length CNGB1a subunit was more susceptible to proteosomal degradation compared to the wild-type counterpart

  5. we report targeting of cyclic nucleotide-gated channel(CNG (show CNGA1 Proteins)) to rod outer segment required interaction with ankyrin-G; ankyrin-G localized to rod outer segments, coimmunoprecipitated with CNG (show CNGA1 Proteins) channel & bound to C-terminal domain of channel beta1 subunit

Mouse (Murine) Cyclic Nucleotide Gated Channel beta 1 (CNGB1) interaction partners

  1. Eliminating Cngb1 and reducing RDS (show PRPH2 Proteins) leads to additive defects in RDS (show PRPH2 Proteins) expression levels and rod electroretinogram (ERG (show ERG Proteins)) function, (e.g., Cngb1-/-/rds (show PRPH2 Proteins)+/- versus rds (show PRPH2 Proteins)+/- or Cngb1-/-) but not to additive defects in rod ultrastructure.

  2. Peripherin-2 links CNGB1 to the light-detector rhodopsin in outer segments of rod photoreceptors.

  3. These results confirm that rods are marginally functional in the absence of the beta-subunit (show POLG Proteins) and in addition show that CFF (show HCFC1 Proteins) (critical flicker frequency)may be a more sensitive measure of remaining functional cone vision

  4. In Cngb1(-/-) x rd1 (show PDE6B Proteins) double mutants, cGMP levels are high, but rod photoreceptor viability and outer segment morphology are improved.

  5. Deletion of the cyclic nucleotide gated channel CNGB1 alters response waveform but leaves light adaptation intact.

  6. Our results show that CNGB1 is a crucial determinant of native cyclic nucleotide-gated channel targeting.

  7. The role of CNGB1 in the function of the olfactory bulb and nucleotide-gated ion channel function is reported.

  8. Ca2 (show CA2 Proteins)+/calmodulin (show Calm2 Proteins)-mediated CNG (show CNGA1 Proteins) channel fast desensitization is less important in regulating the sensitivity to recurring stimulation than previously thought and instead functions primarily to terminate olfactory sensory neuron responses

  9. we report targeting of cyclic nucleotide-gated channel(CNG (show CNGA1 Proteins)) to rod outer segment required interaction with ankyrin-G; ankyrin-G localized to rod outer segments, coimmunoprecipitated with CNG (show CNGA1 Proteins) channel & bound to C-terminal domain of channel beta1 subunit

  10. Knockout of GARPs and the beta-subunit (show POLG Proteins) of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrity.

GARP (CNGB1) Protein Profile

Protein Summary

Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit.

Gene names and symbols associated with CNGB1

  • hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4)
  • cyclic nucleotide gated channel alpha 4 (CNGA4)
  • cyclic nucleotide gated channel beta 1 (CNGB1)
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (hcn4)
  • cyclic nucleotide gated channel beta 1a (cngb1a)
  • cyclic nucleotide gated channel beta 1 (LOC100359123)
  • cyclic nucleotide gated channel beta 1 (Cngb1)
  • CNCG2 protein
  • CNCG3L protein
  • CNCG4 protein
  • CNG4 protein
  • CNGB1 protein
  • Cngb1b protein
  • GAR1 protein
  • GARP protein
  • Gm1959 protein
  • HCN4 protein
  • RCNC2 protein
  • RCNCb protein
  • RCNCbeta protein
  • RP45 protein
  • si:ch211-160j6.1 protein
  • si:ch211-203b17.1 protein

Protein level used designations for CNGB1

hyperpolarization activated cyclic nucleotide-gated potassium channel 4 , cyclic nucleotide gated channel alpha 4 , cardiac hyperpolarization-activated current subunit 4 , cyclic nucleotide gated channel beta 1 , cyclic nucleotide gated channel alpha 3-like , Cyclic nucleotide-gated cation channel alpha-4-like , cyclic nucleotide-gated cation channel beta-1-like , cyclic nucleotide-gated cation channel alpha-4-like , CNG channel beta-1 , CNG-4 , cyclic nucleotide-gated cation channel 4 , cyclic nucleotide-gated cation channel beta-1 , cyclic nucleotide-gated cation channel gamma , cyclic nucleotide-gated cation channel modulatory subunit , cyclic nucleotide-gated channel beta-1 , glutamic acid-rich protein , glutamic-acid-rich protein , cDNA sequence BC016201 , cyclic nucleotide-gated channel beta subunit 1 , 240 kDa protein of rod photoreceptor CNG-channel , CNG channel 4 , CNG4

GENE ID SPECIES
427478 Gallus gallus
430630 Gallus gallus
448794 Canis lupus familiaris
454126 Pan troglodytes
476830 Canis lupus familiaris
516000 Bos taurus
557843 Danio rerio
568211 Danio rerio
611173 Canis lupus familiaris
705414 Macaca mulatta
768759 Gallus gallus
100055033 Equus caballus
100062786 Equus caballus
100358494 Oryctolagus cuniculus
100359123 Oryctolagus cuniculus
100478198 Ailuropoda melanoleuca
100480265 Ailuropoda melanoleuca
706073 Macaca mulatta
1258 Homo sapiens
333329 Mus musculus
83686 Rattus norvegicus
281702 Bos taurus
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