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Cyclin-Dependent Kinase-Like 5 Proteins (CDKL5)

CDKL5 is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Additionally we are shipping CDKL5 Antibodies (70) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CDKL5 6792 O76039
CDKL5 382253 Q3UTQ8
Rat CDKL5 CDKL5 100362725  
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Top CDKL5 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days

CDKL5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for Cyclin-Dependent Kinase-Like 5 (CDKL5) Interaction Partners

Human Cyclin-Dependent Kinase-Like 5 (CDKL5) interaction partners

  1. Mutations in exon 8 of cyclin-dependent kinase-like 5 gene (show GPD1 Proteins) were determined to be disease-causing in epileptic encephalopathy.

  2. study presents the genotype of 2 sisters, a CDKL5 mutation c. 283-3_290del, but different phenotype

  3. Data suggest that the increased dosage of cyclin dependent kinase like 5 protein(CDKL5) might have affected interactions of this kinase with its substrates, leading to perturbation of neurodevelopmental and neurobehavioral abnormalities.

  4. It was indicated that CDKL5 controls excitatory synaptic transmission and the conditions associated with CDKL5 deviation in man indicates synaptic abnormalities.

  5. CDKL5 gene mutations accounted for 5.4% of boys with early onset epileptic encephalopathy

  6. CDKL5 gene is not useful in practical molecular diagnosis of atypical Rett syndrome.

  7. Mutations in the CDKL5 gene associtaed with Hanefield variants of Rett syndrome and early-onset epileptic encephalopathies.

  8. study described the clinical condition and characterization of two first Brazilian patients with CDKL5 mutations, including the first Brazilian case of atypical Rett related to abnormalities in this gene

  9. CDKL5 mutations cause severe epilepsy in infancy with subsequent epileptic encephalopathy.

  10. aberrations of CDKL5 and ARX combined are an important consideration in the genetic forms of early-onset epilepsy in boys

Mouse (Murine) Cyclin-Dependent Kinase-Like 5 (CDKL5) interaction partners

  1. these results point to a role of CDKL5 in the early steps of neuronal differentiation that can be explained, at least in part, by its association with shootin1 (show KIAA1598 Proteins).

  2. Findings highlight a critical role of CDKL5 in the fundamental processes of brain development, namely neuronal precursor proliferation, survival and maturation

  3. Amph1 (show AMPH Proteins) is the cytoplasmic substrate for CDKL5.

  4. CDKL5 regulates signal transduction pathways and mediates autistic-like phenotypes.

  5. a functional axis between MYCN (show MYCN Proteins) and CDKL5 governing both neuron proliferation rate and differentiation.

  6. CDKL5 is localized at excitatory synapses and contributes to correct dendritic spine structure and synapse activity.

  7. both subcellular localization and expression of CDKL5 are modulated by the activation of extrasynaptic N-methyl-D-aspartate receptors and suggest regulation of CDKL5 by cell death pathways.

  8. CDKL5 is involved in pre-mRNA processing (show PRPF39 Proteins), by controlling splicing factor (show SLU7 Proteins) dynamics.

  9. CDKL5 phosphorylation is required for its entrance into the nucleus whereas a portion of the COOH-terminal domain is responsible for a stable residency in this cellular compartment probably through protein-protein interactions

  10. CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail

CDKL5 Protein Profile

Protein Summary

This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized.

Gene names and symbols associated with CDKL5

  • cyclin-dependent kinase-like 5 (CDKL5)
  • cyclin-dependent kinase-like 5 (cdkl5)
  • cyclin-dependent kinase-like 5 (LOC100355402)
  • cyclin-dependent kinase-like 5 (Cdkl5)
  • BC038161 protein
  • EIEE2 protein
  • ISSX protein
  • Stk9 protein

Protein level used designations for CDKL5

cyclin-dependent kinase-like 5 , cyclin-dependent kinase-like 5-like , cyclin dependent kinase 5 transcript , serine/threonine kinase 9 , serine/threonine-protein kinase 9

100057902 Equus caballus
428001 Gallus gallus
100145195 Xenopus (Silurana) tropicalis
100355402 Oryctolagus cuniculus
100407783 Callithrix jacchus
100472831 Ailuropoda melanoleuca
100583908 Nomascus leucogenys
6792 Homo sapiens
382253 Mus musculus
491761 Canis lupus familiaris
100623797 Sus scrofa
538337 Bos taurus
100362725 Rattus norvegicus
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