Cystathionine-beta-Synthase Proteins (CBS)

The protein encoded by CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. Additionally we are shipping Cystathionine-beta-Synthase Antibodies (108) and Cystathionine-beta-Synthase Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CBS 24250 P32232
CBS 12411 Q91WT9
CBS 875 P35520
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Top Cystathionine-beta-Synthase Proteins at

Showing 10 out of 30 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 2 to 3 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Yeast Human His tag   50 μg Log in to see 8 to 11 Days
HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Yeast Yeast His tag   50 μg Log in to see 8 to 11 Days
HOST_Escherichia coli (E. coli) Yeast His tag   50 μg Log in to see 11 Days

CBS Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine)

Human , , , ,
, , ,

Top referenced Cystathionine-beta-Synthase Proteins

  1. Human CBS Protein expressed in Wheat germ - ABIN1348191 : Austgen, Hermann, Dantzler, Rogers, Kline: Hydrogen sulfide augments synaptic neurotransmission in the nucleus of the solitary tract. in Journal of neurophysiology 2011 (PubMed)
    Show all 4 references for 1348191

More Proteins for Cystathionine-beta-Synthase (CBS) Interaction Partners

Chimpanzee Cystathionine-beta-Synthase (CBS) interaction partners

Mouse (Murine) Cystathionine-beta-Synthase (CBS) interaction partners

  1. showed that N-homocysteinylation of collagen in Cbs(-/-) mice impairs its cross-linking

  2. the findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS or CSE (show CTH Proteins) slightly ameliorates the outcome of LPS (show TLR4 Proteins)-induced endotoxemia in vivo.

  3. These data confirm a key role for the H2S-generating enzymes Cbs and Cth (show CTH Proteins) in pulmonary vascular development and homeostasis and in lung alveolarization.

  4. genetic deficiency results in reduced Tet1 (show TET1 Proteins) and Tet2 expression, which leads to hypermethylation of Foxp3 (show FOXP3 Proteins), and impairment of Treg cell differentiation and immune homeostasis.

  5. Elevated homocytsteine levels in the CBS-/+ mouse skeletal muscles caused diminished anti-oxidant capacity and contributed to enhanced total protein as well as PGC-1alpha specific nitrotyrosylation after ischemia.

  6. CBS disruption causes embryo retention and developmental delay in the mouse oviduct.

  7. CBS is present in adrenocortical cells and accounts for H2S generation in adrenal glands. CBS is critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.

  8. Elevating endogenous H2S via CBS over-expression in immortalized microglia not only reduced the expression of pro-inflammatory M1 genes, but also enhanced the anti-inflammatory M2 marker IL-10 (show IL10 Proteins) production.

  9. Cbs protein expression is upregulated in brain cortex following traumatic brain injury.

  10. Brain of mice heterozygous for Cbs displays overexpression of DYR (show DHFR Proteins) kinase and SAH (show ACSM3 Proteins) hydrolase.

Human Cystathionine-beta-Synthase (CBS) interaction partners

  1. SNPs in CBS were not related to relevant changes in homocysteine levels in coronary artery disease patients or controls.

  2. The CBS rs2124459 was associated with a reduced risk of cleft palate in both French and Belgian populations. These results highlight the prominent involvement of the vitamin B6-dependent transsulfuration pathway of homocysteine in orofacial cleft risk and the interest for evaluating vitamin B6 status in further population studies.

  3. There is no ordinary conjunction between human CBS and severe sepsis/septic shock, but CBS genotypes are involved in disease susceptibility.

  4. Oligomeric status of human cystathionine beta-synthase modulates AdoMet (show MAT1A Proteins) binding.

  5. Significant interactions were observed among the methylenetetrahydrofolate reductase (MTHFR (show MTHFR Proteins); C677T; A1298C) and cystathionine-beta-synthase (CBS; T833C/844ins68, G919A) polymorphisms in the results for homocysteine (Hcy) levels, where heterozygous had higher values.

  6. results indicate that binding of SAM (show TTN Proteins) to regulatory and stabilizing sites in CBS may have evolved to display an exquisite thermodynamic and structural specificity towards SAM (show TTN Proteins) as well as the ability to transduce the allosteric signal responsible for CBS activation.

  7. CBS 844ins68 polymorphisms were not associated with Oral squamous cell carcinoma risk in southeastern Brazilians.

  8. This is the first mutational analysis of CBS done in a Filipino patient with classic homocystinuria who presented with a novel duplication mutation and a novel missense mutation.

  9. Two novel compound heterozygous mutations in the CBS gene, c.407T > C (p. L136P) and c.473C > T (p.A158V), were identified in the three patients of a Han Chinese family with homocystinuria

  10. SNP rs11203172 in the CBS gene is associated with a significantly decreased risk to develop early-onset preeclampsia.

Cow (Bovine) Cystathionine-beta-Synthase (CBS) interaction partners

  1. These findings indicate that greater synthesis of phosphatidylcholine (show SGMS1 Proteins) and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.

Cystathionine-beta-Synthase (CBS) Protein Profile

Protein Summary

The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with CBS

  • cystathionine-beta-synthase (cbs-a)
  • cystathionine-beta-synthase (cbs)
  • cystathionine beta-synthase (Cbs)
  • cystathionine-beta-synthase (CBS)
  • cystathionine beta-synthase (CNA06170)
  • cystathionine beta-synthase (Tb11.02.5400)
  • cystathionine beta-synthase CBS (cbs)
  • cystathionine beta-synthase (cbs)
  • cystathionine beta-synthase (cysB)
  • cystathionine beta synthase (Cbs)
  • cystathionine-beta-synthase (cbs-b)
  • cystathionine-beta-synthase b (cbsb)
  • AI047524 protein
  • AI303044 protein
  • cb442 protein
  • cbs protein
  • DDBDRAFT_0189727 protein
  • DDBDRAFT_0191292 protein
  • DDB_0189727 protein
  • DDB_0191292 protein
  • GB12529 protein
  • HIP4 protein
  • wu:fb37g05 protein
  • wu:fm61c07 protein
  • wu:fq06c06 protein
  • zgc:113704 protein

Protein level used designations for CBS

cystathionine-beta-synthase , cystathionine beta-synthase , cystathionine beta-synthase CBS , beta-thionase , hemoprotein H-450 , serine sulfhydrase , methylcysteine synthase

380308 Xenopus laevis
493533 Xenopus (Silurana) tropicalis
551341 Apis mellifera
736626 Pan troglodytes
3253577 Cryptococcus neoformans var. neoformans JEC21
3665875 Trypanosoma brucei brucei strain 927/4 GUTat10.1
4551426 Mycobacterium ulcerans Agy99
6228672 Mycobacterium marinum M
7006755 Rhodospirillum centenum SW
7705918 Gemmatimonas aurantiaca T-27
7712188 Rhodococcus erythropolis PR4
7746532 Rhodococcus opacus B4
8616308 Dictyostelium discoideum AX4
100136726 Oncorhynchus mykiss
100635325 Amphimedon queenslandica
24250 Rattus norvegicus
12411 Mus musculus
446655 Xenopus laevis
418545 Gallus gallus
875 Homo sapiens
611071 Canis lupus familiaris
514525 Bos taurus
100008766 Oryctolagus cuniculus
266987 Danio rerio
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