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The protein encoded by CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. Additionally we are shipping Cystathionine-beta-Synthase Antibodies (106) and Cystathionine-beta-Synthase Kits (13) and many more products for this protein.
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Human CBS Protein expressed in Wheat germ - ABIN1348191
Austgen, Hermann, Dantzler, Rogers, Kline: Hydrogen sulfide augments synaptic neurotransmission in the nucleus of the solitary tract. in Journal of neurophysiology 2011
Show all 4 references for ABIN1348191
the findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS or CSE (show CTH Proteins) slightly ameliorates the outcome of LPS (show TLR4 Proteins)-induced endotoxemia in vivo.
These data confirm a key role for the H2S-generating enzymes Cbs and Cth (show CTH Proteins) in pulmonary vascular development and homeostasis and in lung alveolarization.
genetic deficiency results in reduced Tet1 (show TET1 Proteins) and Tet2 expression, which leads to hypermethylation of Foxp3 (show FOXP3 Proteins), and impairment of Treg cell differentiation and immune homeostasis.
Elevated homocytsteine levels in the CBS-/+ mouse skeletal muscles caused diminished anti-oxidant capacity and contributed to enhanced total protein as well as PGC-1alpha specific nitrotyrosylation after ischemia.
CBS disruption causes embryo retention and developmental delay in the mouse oviduct.
CBS is present in adrenocortical cells and accounts for H2S generation in adrenal glands. CBS is critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.
Elevating endogenous H2S via CBS over-expression in immortalized microglia not only reduced the expression of pro-inflammatory M1 genes, but also enhanced the anti-inflammatory M2 marker IL-10 (show IL10 Proteins) production.
Cbs protein expression is upregulated in brain cortex following traumatic brain injury.
Brain of mice heterozygous for Cbs displays overexpression of DYR (show DHFR Proteins) kinase and SAH (show ACSM3 Proteins) hydrolase.
These findings set the stage to investigate the role of CBS and the transsulfuration pathway in the generation of GSH in mouse retina.
Significant interactions were observed among the methylenetetrahydrofolate reductase (MTHFR (show MTHFR Proteins); C677T; A1298C) and cystathionine-beta-synthase (CBS; T833C/844ins68, G919A) polymorphisms in the results for homocysteine (Hcy) levels, where heterozygous had higher values.
results indicate that binding of SAM (show TTN Proteins) to regulatory and stabilizing sites in CBS may have evolved to display an exquisite thermodynamic and structural specificity towards SAM (show TTN Proteins) as well as the ability to transduce the allosteric signal responsible for CBS activation.
CBS 844ins68 polymorphisms were not associated with Oral squamous cell carcinoma risk in southeastern Brazilians.
This is the first mutational analysis of CBS done in a Filipino patient with classic homocystinuria who presented with a novel duplication mutation and a novel missense mutation.
Two novel compound heterozygous mutations in the CBS gene, c.407T > C (p. L136P) and c.473C > T (p.A158V), were identified in the three patients of a Han Chinese family with homocystinuria
SNP rs11203172 in the CBS gene is associated with a significantly decreased risk to develop early-onset preeclampsia.
In Asian populations, the investigated polymorphisms mapping at TCN2 (show TCN2 Proteins) and CBS genes did not provide any evidence of association with cleft lip/cleftpalate.
Study found a novel association of CD2AP (show Cd2ap Proteins) with plasma homocysteine in participants with African ancestry and found a new variant in the candidate gene CBS associated with homocysteine
Cystathionine-beta-synthase carriers tend to have a higher serum total homocysteine level in the presence of folate deficiency than non-carriers
CBS is involved in regulating lipid metabolism in ovarian cancer cells.
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene.
, cystathionine beta-synthase
, cystathionine beta-synthase CBS
, hemoprotein H-450
, serine sulfhydrase
, methylcysteine synthase