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Cytochrome C Oxidase Subunit IV Isoform 1 Proteins (COX4I1)

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. Additionally we are shipping COX4I1 Antibodies (187) and COX4I1 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COX4I1 1327 P13073
COX4I1 12857 P19783
Rat COX4I1 COX4I1 29445 P10888
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Top COX4I1 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Primate His tag   1 mg Log in to see 56 to 66 Days
$2,035.00
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,097.33
Details
Yeast Primate His tag   1 mg Log in to see 56 to 66 Days
$2,172.50
Details
Yeast Primates His tag   1 mg Log in to see 56 to 66 Days
$2,249.50
Details
Yeast Primate His tag   1 mg Log in to see 56 to 66 Days
$2,289.83
Details
Yeast Pongo pygmaeus His tag   1 mg Log in to see 56 to 66 Days
$2,311.83
Details

COX4I1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

More Proteins for Cytochrome C Oxidase Subunit IV Isoform 1 (COX4I1) Interaction Partners

Human Cytochrome C Oxidase Subunit IV Isoform 1 (COX4I1) interaction partners

  1. We provide evidence that COX4-1 controls BMI1 (show BMI1 Proteins) expression via a redox mechanism

  2. COXIV mRNA (1.6 fold; P<0.01) and COXIV protein expression (1.5 fold; P<0.05) were increased by training but COXIV protein expression was decreased (20%; P<0.01) by acute exercise pre- and post-training.

  3. Identification of three transcription factors that bind a conserved responsive element of the COX4I2 gene, namely recombination signal sequence-binding protein Jkappa (RBPJ (show RBPJ Proteins)), coiled-coil-helix-coiled-coil-helix domain 2 (CHCHD2) and CXXC finger protein 5 (CXXC5 (show CXXC5 Proteins)).

  4. COX (show COX8A Proteins) activity (electron transport complex IV) is reduced by 29% in maternal history of Alzheimer's disease compared to normal controls, and by 30% compared to paternal history of Alzheimer's disease.

  5. Studies suggest a model that links cell signaling with the phosphorylation state of Cytochrome c (Cytc (show CYCS Proteins)) and cytochrome c (show CYCS Proteins) oxidase (COX (show COX8A Proteins)).

  6. Studies suggest that the main function of nuclear encoded subunits of cytochrome c (show CYCS Proteins) oxidase appears to be "only" to control the activity of the mitochondrial subunits.

  7. Studies indicate that the mechanism for proton pumping in cytochrome c (show CYCS Proteins) oxidase is based on an electrostatic analysis of a kinetic experiment for the O to E transition.

  8. Studies indicate that nitric oxide (NO) inhibition of cytochrome c (show CYCS Proteins) oxidase (CcOX (show COX5A Proteins)) is rapid and reversible and may occur in competition with oxygen.

  9. Novel insights into the assembly and function of human nuclear-encoded cytochrome c (show CYCS Proteins) oxidase subunits 4

  10. Data found that subunits Cox6a (show COX6A1 Proteins), Cox6b (show COX6B1 Proteins) and Cox7a (show COX7A1 Proteins) assembled into pre-existing complex IV, while Cox4-1 and Cox6c (show COX6C Proteins) subunits assembled into subcomplexes that may represent rate-limiting intermediates.

Cow (Bovine) Cytochrome C Oxidase Subunit IV Isoform 1 (COX4I1) interaction partners

  1. Studies indicate that the patterns of charge translocation of cytochrome c (show CYCS Proteins) oxidase coupled to transfer of the 3rd and 4th electrons are very similar.

  2. Studies indicate that mutational amino acid replacement in proton channels, at the negative (N) side of membrane-inserted prokaryotic aa(3 (show ACY3 Proteins)) oxidases, as well as Zn(2+) binding at this site in the bovine oxidase, uncouples proton pumping.

  3. Studies indicate that nitric oxide (NO) binding to reduced ba(3) and bovine cytochrome aa3 (show ACY3 Proteins).

  4. Studies indicate that X-ray structure of heart cytochrome c oxidase (CcO) suggest that O(2) molecules are transiently trapped at the Cu(B) site before binding to Fe(a3)(2+) to provide O(2)(-).

  5. Studies indicate that photoexcitation of Ru (II) to Ru(II*) leads to rapid electron transfer to the ferric heme group in cytochrome c (Cc), followed by electron transfer to Cu(A) in cytochrome c oxidase (CcO) with a rate constant of 60,000s(-1).

  6. Studies suggest for the His291 model of proton pumping in cytochrome c oxidase (CcO).

Rabbit Cytochrome C Oxidase Subunit IV Isoform 1 (COX4I1) interaction partners

Mouse (Murine) Cytochrome C Oxidase Subunit IV Isoform 1 (COX4I1) interaction partners

  1. exercise training caused an increase in mRNA and protein levels of COXIV, whereas NAC intervention lowered the two so significantly that even exercise training could not reverse the effect of NAC intervention

  2. Data suggest that that obesity affects both sperm and seminal plasma composition; Cox4i1 mRNA is up-regulated in spermatozoa of obese mice compared to control mice.

  3. Our data suggest that MPP(+) acts on astrocytes in a sex- and brain region-specific manner involving cytochrome c (show CYCS Proteins) oxidase isoform expression in an impairment of energy production and elevated oxidative stress levels

  4. Knockdown of small interfering RNA-mediated COX (show CPOX Proteins) subunit IV decreases progesterone synthesis in steroidogenic cells.

  5. Under conditions of reduced oxygen availability, hypoxia-inducible factor 1 (show HIF1A Proteins) reciprocally regulates COX4 subunit expression by activating transcription of the genes encoding COX4-2 and LON (show LONP1 Proteins), a mitochondrial protease that is required for COX4-1 degradation.

COX4I1 Protein Profile

Protein Summary

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation.

Gene names and symbols associated with COX4I1

  • cytochrome c oxidase subunit IV isoform 1 (COX4I1)
  • cytochrome c oxidase subunit IV isoform 1 (Cox4I1)
  • cytochrome c oxidase polypeptide IV (LOC780848)
  • cytochrome c oxidase polypeptide IV (BMEII0322)
  • cytochrome c oxidase polypeptide IV (RSal33209_1582)
  • cytochrome c oxidase polypeptide IV (SJAG_00976)
  • cytochrome c oxidase polypeptide IV (HMPREF0733_11926)
  • cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)
  • cytochrome c oxidase subunit IV isoform 1 (Cox4i1)
  • cytochrome c oxidase subunit IV isoform 1 (cox4i1)
  • cytochrome c oxidase subunit IV isoform 2 (lung) (COX4I2)
  • AL024441 protein
  • Cox4 protein
  • COX4-1 protein
  • COX4-2 protein
  • Cox4a protein
  • COX4B protein
  • COX4L2 protein
  • COXIV protein
  • COXIV-2 protein
  • dJ857M17.2 protein
  • GB20012 protein
  • mg:bb02d03 protein
  • zgc:110058 protein

Protein level used designations for COX4I1

cytochrome c oxidase subunit 4 isoform 1, mitochondrial , OXPHOS complex IV subunit IV , cytochrome c oxidase polypeptide IV , cytochrome c oxidase subunit IV , COX IV-1 , cytochrome c oxydase subunit 4 , cytochrome c oxidase, subunit IVa , cytochrome c oxidase, subunit 4a , cytochrome c oxidase, subunit IV , Cox4-1 , COX IV-2 , cytochrome c oxidase subunit 4 isoform 2, mitochondrial , cytochrome c oxidase subunit IV-like 2

GENE ID SPECIES
100173464 Pongo abelii
412396 Apis mellifera
100117406 Nasonia vitripennis
780848 Bombyx mori
1198094 Brucella melitensis bv. 1 str. 16M
5824714 Renibacterium salmoninarum ATCC 33209
7050847 Schizosaccharomyces japonicus yFS275
9903229 Rothia dentocariosa ATCC 17931
454391 Pan troglodytes
415826 Gallus gallus
1327 Homo sapiens
479623 Canis lupus familiaris
281090 Bos taurus
100327269 Oryctolagus cuniculus
12857 Mus musculus
29445 Rattus norvegicus
326975 Danio rerio
84701 Homo sapiens
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