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Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 Proteins (CYP1B1)

CYP1B1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP1B1 Antibodies (123) and CYP1B1 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP1B1 1545 Q16678
CYP1B1 13078 Q64429
Rat CYP1B1 CYP1B1 25426 Q64678
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Top CYP1B1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 11 to 13 Days
$880.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days
$914.38
Details

CYP1B1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1) Interaction Partners

Human Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1) interaction partners

  1. CYP1B1/EPHX1 (show EPHX1 Proteins) genotyping could help to predict the risk of DNA damage and to optimize doses of coal tar (show RBM8A Proteins) and UVR exposure in psoriatic patients in whom Goeckerman therapy was applied.

  2. The p.Gly61Glu mutation in CYP1B1 affects the ECM (show MMRN1 Proteins) structure. This implies that the ECM (show MMRN1 Proteins) of the trabecular meshwork may also be disrupted in a manner that affects aqueous humor flow resulting in increased intraocular pressure and contributing to the glaucoma phenotype.

  3. Cytochrome P450-1B1 Gene Polymorphisms are not associated with Risk of Breast Cancer.

  4. CYP1B1 rs1056836 was significantly associated with BCR (show BCR Proteins) (hazard ratio [HR]: 0.69; 95% confidence interval [CI]: 0.40-0.89, P = 0.002) and relative CYP1B1 mRNA expression. Our findings suggest inherited genetic variation in the CYP1B1 gene may contribute to variable clinical outcomes for patients with clinically localized prostate cancer.

  5. either absent or very low CYP1B1 activity levels are the primary molecular defect involved in primary congenital glaucoma pathogenesis.

  6. 3 polymorphisms, rs10012, rs1056827, and rs150799650 in the CYP1B1 gene correlate with urinary bladder cancer significantly in the Indo (show IDO1 Proteins)-European population of Uttar Pradesh, India.

  7. the single nucleotide polymorphisms rs180040 and rs1056827 of CYP1B1 showed an association with risk of primary open-angle glaucoma (Meta-Analysis)

  8. African-American women, the CYP1B1 SNP rs162561 was associated with right ventricular ejection fraction.

  9. CYP1B1 genetic polymorphisms may influence outcome of taxane therapy in Roma and Hungarian populations.

  10. Results show that CYP1B1 may promote renal cell carcinoma (show MOK Proteins) development by inducing CDC20 (show CDC20 Proteins) expression and inhibiting apoptosis through the down-regulation of DAPK1 (show DAPK1 Proteins).

Mouse (Murine) Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1) interaction partners

  1. hypertension, and associated pathogenesis in ApoE (show APOE Proteins)(-/-)/Cyp1b1(+/+) mice on an atherogenic diet are most likely dependent on CYP1B1-generated oxidative stress and increased plasma lipid levels independent of blood pressure and absorption of lipids.

  2. Follicle stimulating hormone functions via p38 MAPK (show MAPK14 Proteins)-induced dephosphorylation at Ser (show SIGLEC1 Proteins)(727) of STAT1 (show STAT1 Proteins) to downregulate Cyp1b1 expression and maintain the estradiol levels in mouse dominant follicles.

  3. Cyp1b1 contributes to angiotensin II induced hypertension and its pathogenesis in male mice.

  4. Suggest that Cyp1b1 plays a critical role in female mice in protecting against renal dysfunction and end-organ damage associated with ANG II (show AGT Proteins)-induced hypertension.

  5. Data indicaate that adduct formation in cytochrome P450 Cyp1b1 knockout mice was significantly reduced compared to wild-type mice receiving dibenzo[def,p]chrysene (DBC).

  6. Cyp1b1 deletion substantially alters the expression of genes associated with fatty acid homeostasis

  7. Data indicate that hepatic stearoyl-CoA desaturase 1 (SCD1) expression was decreased in cytochrome P450 1B1 (CYP1B1)-null mice.

  8. Using inhibitors of p38 (show CRK Proteins) and MSKs, as well as mouse embryonic cells derived from p38alpha (show MAPK14 Proteins)-deficient and MSK1 (show RPS6KA5 Proteins)/2 double knockout mice, we show here that TNF-alpha (show TNF Proteins) potentiates CYP1B1 upregulation via the p38 (show CRK Proteins)/MSK1 (show RPS6KA5 Proteins) kinase cascade

  9. a direct role for mitochondrial CYP1B1 in PAH-mediated oxidative and chemical damage to mitochondria.

  10. Cyp1B1 expression in vascular cells plays an important role in the regulation of the cellular reductive state, thrombospondin (TSP)2 (show THBS2 Proteins) expression, and NF-kappaB (show NFKB1 Proteins) activation.

Zebrafish Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 (CYP1B1) interaction partners

  1. CYP1B1 knockdown studies show CYP1B1 is not a significant factor in causing synergistic toxicity of PAHs, nor, in contrast to CYP1A, in providing protection

CYP1B1 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma\; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.

Gene names and symbols associated with CYP1B1

  • cytochrome P450 1B1 (CYP1B1)
  • cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1)
  • cytochrome P450 1B1-like (LOC100719054)
  • cytochrome P450, family 1, subfamily b, polypeptide 1 (Cyp1b1)
  • cytochrome P450, family 1, subfamily B, polypeptide 1 (cyp1b1)
  • CP1B protein
  • CYP1B protein
  • CYP1B1 protein
  • CYPIB1 protein
  • GLC3A protein
  • P4501b1 protein
  • zgc:136223 protein

Protein level used designations for CYP1B1

cytochrome P450 1B1 , cytochrome P450, family 1, subfamily B, polypeptide 1 , aryl hydrocarbon hydroxylase , cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile) , flavoprotein-linked monooxygenase , microsomal monooxygenase , xenobiotic monooxygenase , CYPIB1 , benz[a]anthracene inducible , cytochrome P450, 1b1, benz[a]anthracene inducible , cytochrome P450CMEF , cytochrome P450EF , P450RAP , cytochrome P450, subfamily 1B, polypeptide 1 , cytochrome P450RAP , cytochrome P4501B

GENE ID SPECIES
100079784 Ornithorhynchus anatinus
100172192 Pongo abelii
459163 Pan troglodytes
100719054 Cavia porcellus
1545 Homo sapiens
428832 Gallus gallus
511470 Bos taurus
13078 Mus musculus
25426 Rattus norvegicus
100150054 Danio rerio
483038 Canis lupus familiaris
421466 Gallus gallus
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