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Cytochrome P450, Family 24, Subfamily A, Polypeptide 1 Proteins (CYP24A1)

CYP24A1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP24A1 Antibodies (83) and CYP24A1 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP24A1 1591 Q07973
CYP24A1 13081 Q64441
Rat CYP24A1 CYP24A1 25279 Q09128
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Top CYP24A1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$862.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,030.69
Details

CYP24A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)
,

More Proteins for Cytochrome P450, Family 24, Subfamily A, Polypeptide 1 (CYP24A1) Interaction Partners

Human Cytochrome P450, Family 24, Subfamily A, Polypeptide 1 (CYP24A1) interaction partners

  1. most heterozygous CYP24A1 mutation carriers have a normal 25OHD/24,25(OH)2D ratio, are usually asymptomatic and have a normal skeletal status but may possibly be at increased risk of nephrocalcinosis

  2. CYP24A1 expression is closely associated with colorectal cancer progression, and it might be a novel prognostic biomarker for CRC (show CALR Proteins).

  3. The CYP24A1 SNP rs927650 may be related to both circulating blood concentrations of 25-hydroxyvitamin D as well as to odds of recurrent colorectal neoplasia.

  4. A definite alteration was seen in vitamin D3-inactivating CYP24A1 gene activity in papillary thyroid carcinoma compared to their normal tissues on a relatively large patient population.

  5. Vitamin D-binding protein (show GC Proteins) SNPs are associated with prostate cancer; low 25(OH)D metabolism score and CYP24A1 and CYP27B1 (show CYP27B1 Proteins) variants are associated with grade

  6. Breast cancer risk may be associated with specific vitamin D-related polymorphisms, particularly CYP24A1 and VDR (show CYP27B1 Proteins).

  7. CYP24A1 biallelic mutations are frequently found in patients presenting with hypercalcemia, low PTH (show PTH Proteins), and renal disease. Haploinsufficiency is not associated with CYP24A1 deficiency.

  8. Data show that cytochrome P450 CYP27B1 (show CYP27B1 Proteins) and CYP24A1 expression were significantly different between tumor and normal tissues in non-small cell lung cancer (NSCLC).

  9. Data suggest that expression of CYP24A1 and cathelicidin is up-regulated in placental extravillous trophoblasts by vitamin D metabolites 1,23-dihydroxyvitamin D3 and 25-hydroxyvitamin D3.

  10. propose three potential human candidate genes for voluntary physical exercise levels (MC3R (show MC3R Proteins), CYP24A1, and GRM8 (show GRM8 Proteins)).

Mouse (Murine) Cytochrome P450, Family 24, Subfamily A, Polypeptide 1 (CYP24A1) interaction partners

  1. results link CYP24 activity to the pathophysiology of FGF23 (show FGF23 Proteins)-dependent renal phosphate wasting states and implicate pharmacologic CYP24 inhibition as a therapeutic adjunct for their treatment.

  2. Gsalpha is required in proximal tubules for suppressing renal vitamin D 24-hydroxylase mRNA levels and for maintaining normal serum 1,25(OH)2D.

  3. Data suggest that control of CYP24A1 increase during diabetes has a beneficial effect on senescence induction and caspase-3 (show CASP3 Proteins) increased expression.

  4. the mechanism through which 1,25(OH)(2)D(3) induces the CYP24A1 enzyme

  5. The expression of vitamin D 24-hydroxylase gene was directly regulated by serum calcium rather than 25-hydroxyvitamin D 1 alpha-hydroxylase.

  6. Results show that Inhibition of 24-OHase activity modulates serum calcitriol PK in normal C3H/HeJ mice.

  7. Cyp24a1 deficiency delays fracture repair and strongly suggest that vitamin D metabolites hydroxylated at position 24, such as 24,25(OH)2D3, play an important role in the mechanisms leading to normal fracture hea

  8. 1,25(OH)2D is the preferred substrate for CYP24 in murine kidney mitochondria.

  9. findings demonstrate that regulation of both the 25-hydroxyvitamin D-1 alpha-hydroxylase and 25-hydroxyvitamin D-24-hydroxylase genes by phosphorus is disordered in hypophosphatemic mice at the level of renal mRNA expression

  10. the absence of CYP24A1 or vitamin D receptor (show VDR Proteins) retards catabolism of 1alpha,25(OH)2D3 and 25(OH)D3

CYP24A1 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CYP24A1

  • cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1)
  • cytochrome P450, family 24, subfamily a, polypeptide 1 (Cyp24a1)
  • 24-OHase protein
  • 25-hydroxyvitaminD324-hydroxylase protein
  • CP24 protein
  • CP450CC24 protein
  • Cyp24 protein
  • HCAI protein
  • P450-CC24 protein
  • VITD12 protein

Protein level used designations for CYP24A1

1,25-@dihydroxyvitamin D3 24-hydroxylase , 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial , 24-OHase , cytochrome P450 24A1 , cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase) , cytochrome P450-CC24 , exo-mitochondrial protein , vitamin D 24-hydroxylase , vitamin D(3) 24-hydroxylase , 25-hydroxyvitamin D-24-hydroxylase , cytochrome P450, 24 , cytochrome P450, 24a1 , 24R-Ohase , 25-hydroxyvitamin D3 24-hydroxylase , Cytochrom P450 (25-hydroxyvitamin D24-hydroxylase) , P450-CC24 , cytochrome P450, subfamily 24 , 25-hydroxyvitamin D3-24-hydroxylase

GENE ID SPECIES
1591 Homo sapiens
13081 Mus musculus
25279 Rattus norvegicus
395827 Gallus gallus
485935 Canis lupus familiaris
397145 Sus scrofa
540080 Bos taurus
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