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anti-Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) Antibodies

CYP27B1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP27B1 Kits (9) and CYP27B1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CYP27B1 1594 O15528
CYP27B1 114700 O35132
CYP27B1 13115 O35084
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Top anti-CYP27B1 Antibodies at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of CYP27B1 Antibody (C-term) (ABIN652999) in mouse kidney tissue lysates (35 µg/lane). CYP27B1 (arrow) was detected using the purified polyclonal antibody. CYP27B1 Antibody (C-term) (ABIN652999) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Flow cytometric analysis of 293 cells using CYP27B1 Antibody (C-term) Cat.-No AP51167PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue stained with CYP27B1 Antibody (C-term) Cat.-No AP51167PU-N  followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of CYP27B1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-CYP27B1 Picoband antibody, IHC(P) IHC(P): Rat Kidney Tissue Anti-CYP27B1 Picoband antibody, IHC(P) IHC(P): Human Kidney Cancer Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$385.00
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$396.00
Details
Rat Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$418.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB   400 μL Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit PE IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$903.83
Details
Human Rabbit APC IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$903.83
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$903.83
Details

CYP27B1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Rat (Rattus) ,


Mouse (Murine) ,


Top referenced anti-CYP27B1 Antibodies

  1. Human Polyclonal CYP27B1 Primary Antibody for FACS, IHC (p) - ABIN652999 : Simon, Munger, Xing Yang, Ascherio: Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis. in Multiple sclerosis (Houndmills, Basingstoke, England) 2010 (PubMed)
    Show all 4 references for ABIN652999

  2. Human Polyclonal CYP27B1 Primary Antibody for FACS, IHC (p) - ABIN951779 : Zhou, LeBoff, Glowacki: Vitamin D metabolism and action in human bone marrow stromal cells. in Endocrinology 2009 (PubMed)
    Show all 2 references for ABIN951779

More Antibodies against CYP27B1 Interaction Partners

Cow (Bovine) Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) interaction partners

  1. Data show that in tissue and secreted cells from the infected mammary glands, 25-hydroxyvitamin D(3) 1alpha-hydroxylase (1alpha-OHase; CYP27B1) gene expression was significantly increased compared to expression in tissue and cells from the healthy mammary tissue.

Human Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) interaction partners

  1. This study reveals no association between CYP27B1 polymorphisms and blood levels of 1alpha,25-hydroxyvitamin D.

  2. this study indicates rs8176345 in CYP27B1 gene is significantly correlated with erlotinib-induced skin rash in patients with advanced non-small cell lung cancer

  3. Vitamin D-binding protein (show GC Antibodies) SNPs are associated with prostate cancer; low 25(OH)D metabolism score and CYP24A1 (show CYP24A1 Antibodies) and CYP27B1 variants are associated with grade

  4. Increased CYP27B1 expression and local duodenal 1,25(OH)2D3 production during puberty may be a metabolic adaptation that promotes dietary calcium absorption.

  5. Data show that cytochrome P450 (show CYP Antibodies) CYP27B1 and CYP24A1 (show CYP24A1 Antibodies) expression were significantly different between tumor and normal tissues in non-small cell lung cancer (NSCLC).

  6. Data suggest compound heterozygous mutations in CYP27B1 (missense/frameshift mutations) in 2 brothers are associated with vitamin D-dependent rickets type 1A; entering puberty urinary calcium is marker for secondary hyperparathyroidism. [CASE REPORT]

  7. The CYP27B1+2838 polymorphism may be useful as pretreatment factor to selection of patients with higher probability of response to therapy.

  8. LNCaP cells were stably transfected with CYP27B.

  9. Results suggest that local expression of CYP27B1 in ovarian tumor cells can modify their behavior and promote a less aggressive phenotype by affecting local concentrations of active of vitamin D levels within the tumor microenvironment.

  10. Case Report: novel pathogenic missense mutation (CYP27B1:Homozygous c.1510C > T(p.Q504X)) causing vitamin D-dependent rickets type 1.

Mouse (Murine) Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1) interaction partners

  1. P450C1 alpha deficiency results in abnormal calcium handling and cardiac dysfunction in mice with defective vitamin D signaling.

  2. Throughout the male reproductive tract specific bands of CYP27B1 are determined.

  3. observed a 3- to 10-fold increase in CYP27B1 mRNA abundance in the lung, spleen, aorta and testis of FGF-23 (show FGF23 Antibodies) null/1alpha-Luc mice

  4. Data show that the absence of either of the two key hydroxylases, vitamin D 25-hydroxylase (CYP2R1 (show CYP2R1 Antibodies)) or vitamin D 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)neither inhibits nor enhances the development of experimental autoimmune encephalomyelitis (EAE).

  5. These results confirm the expression of vitamin D receptor (show VDR Antibodies) and Cyp27b1 in vivo and suggest a potential role for vitamin D(3) in skeletal muscle regeneration following injury.

  6. Bone formation parameters were increased significantly in all pups fed by dams on the rescue diet but were still lower in 1alpha(OH)ase(-/-) pups than in 1alpha(OH)ase(+/-) pups.

  7. regulation of bone CYP27B1 is unique from that in the kidney, and may play an important role in bone formation

  8. study shows CYP27B1 can hydroxylate 25-hydroxyvitamin D2 & 25-hydroxyvitamin D3 associated with phospholipid membranes; low activity found at higher membrane levels of 25-hydroxyvitamin D; substrate inhibition may contribute to enzyme activity regulation

  9. findings demonstrate that regulation of both the 25-hydroxyvitamin D-1 alpha-hydroxylase and 25-hydroxyvitamin D-24-hydroxylase (show CYP24A1 Antibodies) genes by phosphorus is disordered in hypophosphatemic mice at the level of renal mRNA expression

  10. both 1alphaOHase gene ablation and Pi supplementation inhibit renal calcification in Npt2 (show SLC34A1 Antibodies)-/- mice and that 1,25(OH)2D is essential for the development of hypercalciuria and nephrocalcinosis in the mutant strain.

CYP27B1 Antigen Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.

Gene names and symbols associated with CYP27B1

  • cytochrome P450, family 27, subfamily B, polypeptide 1 (cyp27b1) antibody
  • cytochrome P450, family 27, subfamily B, polypeptide 1 (CYP27B1) antibody
  • cytochrome P450, family 27, subfamily b, polypeptide 1 (Cyp27b1) antibody
  • Cp2b antibody
  • Cyp1 antibody
  • CYP1alpha antibody
  • Cyp27b antibody
  • Cyp40 antibody
  • P450c1 antibody
  • Pddr antibody
  • Vdd1 antibody
  • Vddr antibody
  • VddrI antibody
  • Vdr antibody

Protein level used designations for CYP27B1

cytochrome P450, family 27, subfamily B, polypeptide 1 , 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial , mitochondrial 25 hydroxyvitamin D3-1alpha-hydroxylase , 1alpha(OH)ase , 25 hydroxyvitamin D3-1-alpha hydroxylase , 25-OHD-1 alpha-hydroxylase , VD3 1A hydroxylase , calcidiol 1-monooxygenase , cytochrome P450 subfamily XXVIIB polypeptide 1 , cytochrome P450C1 alpha , cytochrome P450VD1-alpha , cytochrome p450 27B1 , 25-hydroxyvitamin D(3) 1-alpha-hydroxylase , P450C1 alpha , P450VD1-alpha , cytochrome P450 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase) , cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1 , cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase) , cytochrome P450, subfamily 27b, polypeptide 1 , 25(OH)D 1alpha-hydroxylase , 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D3 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha) , 25-hydroxyvitamin D3 1alpha-hydroxylase , P450VD1alpha , cytochrome P450, 27b1

GENE ID SPECIES
448754 Xenopus (Silurana) tropicalis
452027 Pan troglodytes
539630 Bos taurus
715747 Macaca mulatta
100034100 Equus caballus
1594 Homo sapiens
114700 Rattus norvegicus
13115 Mus musculus
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