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Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Proteins (CYP3A4)

CYP3A4 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP3A4 Antibodies (92) and CYP3A4 Kits (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP3A4 1576 P08684
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Top CYP3A4 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Yeast (Pichia pastoris) Human Un-conjugated   10 mg Log in to see 2 to 3 Days
$157.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CYP3A4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,

More Proteins for Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) Interaction Partners

Horse (Equine) Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) interaction partners

  1. It was concluded that CYP3A related metabolism in horse is not solely dependent on the expression of the enzyme but also on adequate levels of NADPH P450 reductase (show POR Proteins) and cytochrome b(5 (show CYB5A Proteins)).

Rhesus Monkey Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) interaction partners

  1. study of genetic variants of CYP3A4 in cynomolgus and rhesus macaques from China

Human Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4) interaction partners

  1. Both donor and recipient CYP3A5 (show CYP3A5 Proteins) genotype significantly influences tacrolimus once daily pharmacokinetics in stable liver transplant recipients, while CYP3A4*22 is not a suitable biomarker

  2. Data provides evidence that CYP3A4*22 (rs35599367) increases the formation of the nonfunctional CYP3A4 splice variant with partial intron 6 retention, thereby reducing the production of functional full-length CYP3A4 mRNA.

  3. Early postpartum women possessed higher CYP3A activity based on plasma 4beta-hydroxycholesterol and had a large pharmacokinetic variability in amlodipine disposition.

  4. patients who expressed CYP3A5 (show CYP3A5 Proteins)*3 had an increased incidence of vincristine-related neurotoxicity.

  5. Report CYP3A4 induction in six fully characterized cryopreserved human hepatocyte preparations and HepaRG cell line.

  6. The shape and localization of human CYP3A4 protein embedded in a phospholipid nanodisc environment has been determined.

  7. a critical role of the CYP3A5 (show CYP3A5 Proteins) 6986A>G and CYP3A4 -392A>G polymorphisms on the variation of Tac (show IL2RA Proteins) exposure during the early and the late post-transplant phase, respectively.

  8. CYP3A4-expressing recombinant human liver microsomal preparation showed significantly higher Km for the formation of 1'-hydroxymidazolam than baculovirus-infected insect cell microsomes.

  9. CYP3A4 further activates, rather than inactivates, 20-hydroxy vitamin D3.

  10. In this cohort study in morbidly obese patients, systemic clearance of midazolam was 1.7 times higher 1 year after bariatric surgery, which may potentially result from an increase in hepatic CYP3A activity per unit of liver weight.

CYP3A4 Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist\; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with CYP3A4

  • cytochrome P450 3A4 (PTRG_01782)
  • cytochrome P450 3A4 (PTRG_06060)
  • cytochrome P450, family 3, subfamily A, polypeptide 4 (cyp3a4)
  • cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4)
  • cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 (CYP3A4)
  • cytochrome P450, subfamily IIIA, polypeptide 4 (CYP3A4)
  • CP33 protein
  • CP34 protein
  • CYP3A protein
  • CYP3A3 protein
  • CYP3A4 protein
  • CYP3A12 protein
  • CYP3A21 protein
  • CYP3A80 protein
  • CYPIIIA3 protein
  • CYPIIIA4 protein
  • CYPIIIA21 protein
  • HLP protein
  • MGC108372 protein
  • NF-25 protein
  • P450C3 protein
  • P450PCN1 protein

Protein level used designations for CYP3A4

cytochrome P450 3A4 , cytochrome P450, family 3, subfamily A, polypeptide 4 , cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 , Cytochrome P450 CM3A-10 , cytochrome P450 3A21 , 1,8-cineole 2-exo-monooxygenase , P450-III, steroid inducible , albendazole monooxygenase , albendazole sulfoxidase , cytochrome P450 3A3 , cytochrome P450 HLp , cytochrome P450 NF-25 , cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 , cytochrome P450-PCN1 , glucocorticoid-inducible P450 , nifedipine oxidase , quinine 3-monooxygenase , taurochenodeoxycholate 6-alpha-hydroxylase , cytochrome P450 CYP3A12 , cytochrome P450 3A80

GENE ID SPECIES
6339762 Pyrenophora tritici-repentis Pt-1C-BFP
6344316 Pyrenophora tritici-repentis Pt-1C-BFP
548503 Xenopus (Silurana) tropicalis
463582 Pan troglodytes
100037189 Xenopus laevis
100294525 Equus caballus
100404344 Callithrix jacchus
100462903 Macaca mulatta
1576 Homo sapiens
479740 Canis lupus familiaris
416477 Gallus gallus
507988 Bos taurus
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