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CYP46A1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 Kits (8) and Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 Proteins (4) and many more products for this protein.
Showing 10 out of 58 products:
Human Polyclonal CYP46A1 Primary Antibody for EIA, WB - ABIN318821
Pikuleva: Cytochrome P450s and cholesterol homeostasis. in Pharmacology & therapeutics 2006
Show all 3 references for ABIN318821
Cow (Bovine) Polyclonal CYP46A1 Primary Antibody for WB - ABIN2773829
Galluzzi, Geroldi, Benussi, Ghidoni, Testa, Borsci, Bonetti, Manfellotto, Romanelli, Zulli, Binetti, Frisoni: Association of blood pressure and genetic background with white matter lesions in patients with mild cognitive impairment. in The journals of gerontology. Series A, Biological sciences and medical sciences 2008
hippocampal CYP46A1 protein and 24S-hydroxycholesterol levels were reduced in a mouse model of Alzheimer's Disease-like Tau neuropathology
under conditions of membrane cholesterol reduction by increased CYP46A1 expression, neurons increase isoprenoid synthesis and sGTPase prenylation. This leads to a reduction in liver X receptor activity
Human CYP46A1 oxidizes 7-dehydrocholesterol to 24-hydroxy-7-dehydrocholesterol and 25-hydroxy-7-dehydrocholesterol.
While there were no differences in cognitive performance between participants with and those without metabolic syndrome, ApoE (show APOE Antibodies) and CYP46 genotypes did correlate with mental manipulation scores.
results of meta-analysis suggested that CYP46A1 rs754203 is a minor risk factor for Alzheimer's disease
An meta-analysis has successfully proved that CC genotype of the CYP46A1 T/C polymorphism could increase the risk of Alzheimer's disease.
A meta-analysis indicates that the CYP46 gene SNP rs754203 is not significantly associated with sporadic Alzheimer's disease susceptibility in Chinese Han populations.
To identify the determinants of tight azole binding to CYP46A1.
analysis of binding of the cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1
The intronic polymorphism in CYP46A1 is associated with Alzheimer disease in a Chinese Han population, and the CYP46A1 T allele might be a risk factor.
EFV enhanced CYP46A1 activity and cerebral cholesterol turnover in animals with no effect on the levels of brain cholesterol.
Increased expression of CYP46A1 in the striatum decreased neuronal atrophy in a Huntington's disease model.
the CYP46 gene locus may predispose to Alzheimer's disease by increasing the 24S-hydroxycholesterol/cholesterol ratio in the brain.
The expression of CYP46A1, as well as other cytochrome P450s involved in cholesterol homeostasis, are potently regulated by histone acetylation status.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
, cytochrome P450, family 46, subfamily A, polypeptide 1
, cytochrome P450, family 46
, cytochrome P450 46A1
, cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
, cholestrol 24-hydroxylase
, cytochrome P450, 46 (cholesterol 24-hydroxylase)
, cytochrome P450, 46a1 (cholesterol 24-hydroxylase)