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CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. Additionally we are shipping CTLA4 Antibodies (452) and CTLA4 Proteins (85) and many more products for this protein.
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Data show that CTLA-4(+)PD-1 (show PDCD1 ELISA Kits)(-) memory CD4 (show CD4 ELISA Kits)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (show GUSB ELISA Kits), and contained replication-competent and infectious virus.
data suggest that increased expression of checkpoint blockade molecules PD-1 (show PDCD1 ELISA Kits) and CTLA-4 on donor T cells is not sufficient to prevent GvHD, and that cooperation between checkpoint blockade signaling by host cells and donor Tregs is necessary to limit GvHD in allo-HSCT recipients
Treg cells expand in both humans and mice in blood-stage malaria and interfere with conventional T helper cell responses and follicular T helper (TFH)-B cell interactions in germinal centers. Mechanistically, Treg cells function in a critical temporal window to impede protective immunity through cytotoxic-T-lymphocyte-associated protein-4 (CTLA-4).
CTLA-4 expressed by FOXP3 (show FOXP3 ELISA Kits)(+) regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis.
results are consistent with a complex pathway in which CD28 (show CD28 ELISA Kits) is the primary driver of Treg proliferation and CTLA-4 functions as the main brake but is also dependent on TCR signals and interactions with CD80 (show CD80 ELISA Kits)/CD86 (show CD86 ELISA Kits)
CTLA-4(+) microvesicles can competitively bind B7 costimulatory molecules on bystander dendritic cells, resulting in downregulation of B7 surface expression.
this study shows that miR (show MLXIP ELISA Kits)-155 is modulated by a major dust mite allergen, Dermatophagoides farinae (Df1), and increases CD4 (show CD4 ELISA Kits)+ T cell proliferation through the downregulation of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expression
CTLA-4 regulates atherosclerosis by suppressing proatherogenic immune responses.
Data suggest enhanced clinical benefit from combining CTLA-4 antigen blockade with poxvirus-based active immunotherapy.
up-regulated expression correlates with the tolerogenic effect of syngeneic hematopoietic stem cell transplantation
Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner
CTLA-4 expressing Th17 cells may present regulatory activities in pancreatic cancer patients.
Data show there was an independent negative prognostic impact of cytotoxic T lymphocyte associated antigen 4 (T-CTLA-4) expression in metastatic lymph nodes.
High CTLA4 expression is associated with B-cell lymphoma.
In this discovery cohort, the combination of PD-1 (show PDCD1 ELISA Kits) and CTLA-4 emerged as the best predictor of response. Patients whose tumors had at least 20% of CD8 (show CD8A ELISA Kits)+ T cells expressing these two markers had a median progression-free survival of 31.6 months, versus 9.6 months for patients with less than 20% of this subtype among their tumor CD8 (show CD8A ELISA Kits)+ cells
Review/Meta-analysis: CTLA-4 may not be a major susceptibility locus in humans with ankylosing spondylitis.
This review focuses on the pathogenesis, clinical manifestations and management of immune-related toxicity of anti-CTLA-4 and anti-PD-1 (show PDCD1 ELISA Kits) antibodies
The CTLA-4 blockade may restore Th1 (show TH1L ELISA Kits) function in patients with COPD (show ARCN1 ELISA Kits) and so aid the clearance of bacterial pathogens responsible for acute exacerbations of chronic obstructive pulmonary disease.
High CTLA4 expression is associated with head-and-neck squamous cell carcinoma.
AUthors observed a significant correlation between the proportion of Tregs and (in)CTLA-4+ Tregs with IL-17A (show IL17A ELISA Kits) concentration in clBALF. Data confirmed significant differences in the proportion of regulatory elements between cancerous lung and healthy lung and PB and the usefulness of BALF analysis in evaluation of immune response regulation in local lung cancer environment.
Suggest a truncated diphtheria toxin based recombinant porcine CTLA-4 fusion toxin as a novel approach for in vivo depletion of CD80 (show CD80 ELISA Kits)-positive cells.
The surface expression of CTLA-4 was increased in subclinical stages of paratuberculosis infection while levels of ZAP-70 (show ZAP70 ELISA Kits) were decreased in CD4 (show CD4 ELISA Kits)+ T cells of both subclinical and clinical animals, indicating a change in T cell phenotype with disease state.
These results suggested that the expression level of CTLA-4 in CD4 (show CD4 ELISA Kits)-positive T cells has a potentially immunosuppressive function in bovine leukemia infection.
Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 (show FOXP3 ELISA Kits) and CTLA4.
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
cytotoxic T-lymphocyte-associated protein 4 precursor
, CD152 protein
, cytotoxic T-lymphocyte protein 4
, cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM
, cytotoxic T-lymphocyte-associated protein 4
, costimulatory molecule B7 receptor
, cytotoxic T lymphocyte-associated antigen 4
, CD152 antigen
, cytotoxic T-lymphocyte-associated antigen 4
, CD152 isoform
, celiac disease 3
, cytotoxic T lymphocyte associated antigen 4 short spliced form
, cytotoxic T-lymphocyte antigen 4
, cytotoxic T-lymphocyte-associated serine esterase-4
, ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
, soluble form
, transmembrane form
, cytotoxic T lymphocyte-associated protein 4
, costimulatory molecule B7 receptor CD152