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D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. Additionally we are shipping D-Dopachrome Tautomerase Antibodies (76) and D-Dopachrome Tautomerase Kits (22) and many more products for this protein.
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Study demonstrated that DDT was over- expressed in pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines in a pattern correlated with MIF (show AMH Proteins), and knockdown of DDT and MIF (show AMH Proteins) in PANC- 1 cells cooperatively inhibited cell proliferation, invasion and tumor formation. The tautomerase activities of both MIF (show AMH Proteins) and DDT are required for their negative regulatory role in p53 (show TP53 Proteins) and their tumor-promoting functions.
DDT was increased in burn patients.
Gene expression level of DDT is significantly higher in AD patients when compared to normal controls.
High MIF-2 levels are predictive of the development of organ dysfunction in myocardial ischemia reperfusion injury.
Both p53 (show TP53 Proteins) wildtype and mutant human lung adenocarcinoma tumors rely on MIF (show AMH Proteins) family members for maximal cell growth and survival.
findings identify DDT as a functionally redundant but more potent cytokine to MIF (show AMH Proteins) in cancer and suggest that current attempts to inhibit MIF (show AMH Proteins) signaling may fail because of DDT compensation.
D-dopachrome tautomerase secreted from adipocytes acts on preadipocytes to promote IL-6 (show IL6 Proteins) expression and to inhibit adipogenesis by suppressing the induction of genes encoding adipogenic regulators
DDT acts on adipocytes to regulate lipid metabolism through AMPK (show PRKAA1 Proteins) and/or PKA pathway(s) and improves glucose intolerance caused by obesity.
These data indicate that D-DT is a MIF (show AMH Proteins)-like cytokine.
D-DT-dependent beta-catenin (show CTNNB1 Proteins) stabilization is regulated by COX-2 expression, suggesting the existence of an amplification loop between COX-2- and beta-catenin (show CTNNB1 Proteins)-mediated transcription in these cells
cardiomyocyte secretion of DDT has important autocrine/paracrine effects during ischemia-reperfusion that protect the heart against injury
These data point to a potential involvement of D-dopachrome tautomerase activity in the mature mouse brain, and suggest some functional and evolutionary relationship between innate immunity and tautomerization of D-dopachrome in mammalian species
These data indicate that D-DT is a MIF (show MIF Proteins)-like cytokine.
D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22.
, D-dopachrome decarboxylase-A
, D-dopachrome tautomerase-A
, D-dopachrome decarboxylase-B
, D-dopachrome tautomerase-B
, D-dopachrome tautomerase
, dopachrome isomerase
, phenylpyruvate tautomerase II