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DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Additionally we are shipping DNA (Cytosine-5)-Methyltransferase 1 Kits (25) and DNA (Cytosine-5)-Methyltransferase 1 Proteins (8) and many more products for this protein.
Showing 10 out of 475 products:
Human Polyclonal DNMT1 Primary Antibody for FACS, WB - ABIN387878
Peterson, Bögler, Taylor: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. in Cancer research 2003
Show all 7 references for 387878
Human Polyclonal DNMT1 Primary Antibody for WB - ABIN387879
Leu, Rahmatpanah, Shi, Wei, Liu, Yan, Huang: Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. in Cancer research 2003
Show all 7 references for 387879
Fish Monoclonal DNMT1 Primary Antibody for ChIP, IP - ABIN1027706
Bestor, Laudano, Mattaliano, Ingram: Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. in Journal of molecular biology 1989
Show all 6 references for 1027706
Fish Monoclonal DNMT1 Primary Antibody for ChIP, IP - ABIN361726
Okano, Bell, Haber, Li: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. in Cell 1999
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Human Polyclonal DNMT1 Primary Antibody for EIA, WB - ABIN356564
Saito, Kanai, Nakagawa, Sakamoto, Saito, Ishii, Hirohashi: Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. in International journal of cancer. Journal international du cancer 2003
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Human Polyclonal DNMT1 Primary Antibody for DB - ABIN389901
Siedlecki, Garcia Boy, Comagic, Schirrmacher, Wiessler, Zielenkiewicz, Suhai, Lyko: Establishment and functional validation of a structural homology model for human DNA methyltransferase 1. in Biochemical and biophysical research communications 2003
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Human Polyclonal DNMT1 Primary Antibody for EIA - ABIN358462
Liao, Siu, Chan, Wong, Ngan, Chan, Li, Khoo, Cheung: Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis. in International journal of cancer. Journal international du cancer 2008
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Human Polyclonal DNMT1 Primary Antibody for DB - ABIN389917
Dion, Lin, Hubert, Waterland, Wilson: Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline. in Human molecular genetics 2008
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Human Polyclonal DNMT1 Primary Antibody for EIA - ABIN358447
Yang, Andrade, Labialle, Moussette, Geneau, Sinnett, Belisle, Greenwood, Naumova: Parental effect of DNA (Cytosine-5) methyltransferase 1 on grandparental-origin-dependent transmission ratio distortion in mouse crosses and human families. in Genetics 2008
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Human Polyclonal DNMT1 Primary Antibody for IF (p), IHC (p) - ABIN671796
Khan, Tania, Wei, Mei, Fu, Cheng, Xu, Fu: Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition. in Oncotarget 2015
Dnmt1 stability requires UHRF1 (show UHRF1 Antibodies) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation
Lsh (show HELLS Antibodies) Is Essential for Maintaining Global DNA Methylation (show HELLS Antibodies) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.
Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (show CEBPA Antibodies) regulation during definitive hematopoiesis in zebrafish
These data provide the first evidence that Uhrf1 (show UHRF1 Antibodies) and Dnmt1 function is required for vertebrate lens development and maintenance.
These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (show SUV39H1 Antibodies) and that, together, Dnmt1 and Suv39h1 (show SUV39H1 Antibodies) help guide the terminal differentiation of particular tissues.
Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.
Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.
these results indicate that DNMT1 mediates aberrant methylation and silencing of SHP-1 gene in chronic myelogenous leukemia cells
reciprocal regulation between miR (show MLXIP Antibodies)-148a/152 and DNMT1 in foam cells
MUC1 (show MUC1 Antibodies)-C is of functional importance to induction of DNMT1 and DNMT3b (show DNMT3B Antibodies) and, in turn, changes in DNA methylation (show HELLS Antibodies) patterns in cancer cells.
This study demonstrates novel regulatory circuits involving miR (show MLXIP Antibodies)-148a-3p/ERBB3 (show ERBB3 Antibodies)/AKT2 (show AKT2 Antibodies)/c-myc (show MYC Antibodies) and DNMT1 that controls bladder cancer progression, which may be useful in the development of more effective therapies against bladder cancer.
a novel molecular mechanism by which MBD4 (show MBD4 Antibodies) inhibits GITR (show TNFRSF18 Antibodies) expression in a DNMT1-dependent manner
a model in which the EZH2 (show EZH2 Antibodies)/HOXA11 (show HOXA11 Antibodies)-AS/LSD1 (show KDM1A Antibodies) complex and HOXA11 (show HOXA11 Antibodies)-AS/miR (show MLXIP Antibodies)-1297/EZH2 (show EZH2 Antibodies) cross-talk serve as critical effectors in gastric cancer tumorigenesis and progression.
Studies indicate that DNA methylation (show HELLS Antibodies) is mediated by three DNA (Cytosine-5-)-Methyltransferase (DNMTs): DNMT1 is responsible for the maintenance of methylation patterns after DNA replication whereas DNMT3A (show DNMT3A Antibodies) and DNMT3B (show DNMT3B Antibodies) carry out de novo methylation, and DNMT inhibitors have showed promising results in clinical trials of prostate cancer.
Our results suggest that epigenetic alteration of histone demethylation regulated by reduction of DNMT1 may control induction of EMT (show ITK Antibodies) and the CSC phenotype, which facilitates tumorigenesis in PCa (show FLVCR1 Antibodies) cells and has important therapeutic implications in targeting epigenetic regulation.
results indicated that the age and total cholesterol concentrations were independent influential factors of ChREBP (show MLXIPL Antibodies) methylation and DNMT1 variants could probably influence LDL-C to further modify ChREBP (show MLXIPL Antibodies) DNA methylation (show HELLS Antibodies)
DNMT1 overexpression is associated with Breast Cancer.
Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (show DNMT3A Antibodies), Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 (show UHRF1 Antibodies) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm (show NLRP5 Antibodies) cortex of oocytes and cytoplasm of early embryos.
results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos
Oocyte-specific Dnmt1 is cytoplasmic during early development.
Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.
DNMT1 silencing significantly decreased the methylation levels of miR (show MYLIP Antibodies)-29b promoter, up-regulated miR (show MYLIP Antibodies)-29b expression and inhibited bovine viral diarrhea virus replication.
Through down-regulating the expression of DNMT1, miR (show MYLIP Antibodies)-152 reduced Global DNA methylation (show HELLS Antibodies) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (show AKT1 Antibodies) and Ppar gamma (show PPARG Antibodies).
More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (show ASCL2 Antibodies) mRNA was present at highest levels in transgenic SCNT embryos.
Our results indicate an essential role for Dnmt1 during bovine preimplantation development (show MTA2 Antibodies), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.
Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos
Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.
Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.
Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.
MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis
Met1 gene expression throughout normal development, particularly in the flower
MET1 is a contributor to epigenetic diversity in Arabidopsis.
VIM (show VIM Antibodies) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (show HELLS Antibodies) and histone modification status in collaboration with MET1
VIM (show VIM Antibodies) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (show HELLS Antibodies) pathway.
Genetic studies indicate that the Polycomb (show CBX2 Antibodies) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]
MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.
There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation (show HELLS Antibodies) in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.
Our results bear interesting similarities with cancer cells, which show global losses of DNA methylation (show HELLS Antibodies) but ectopic hypermethylation of genes previously marked by H3K27m3.
An intergenic nucleosome-free crossover hotspot 3a undergoes increased recombination activity in met1.
indispensable role of DNMT1-mediated epigenetic regulation in postnatal liver growth and regeneration
SETDB1 (show SETDB1 Antibodies) maintains silencing of intracisternal A particle, but in the absence of DNMT1, prolonged binding of NP95 (show UHRF1 Antibodies) to hemimethylated DNA transiently disrupts SETDB1 (show SETDB1 Antibodies)-dependent H3K9me3 deposition.
Arx and Dnmt1 that are sufficient for achieving targeted generation of beta cells from adult pancreatic alpha cells.
The results of this study showed that DNA Methyltransferase 1 is main role of Development of the Hippocampal Dentate Gyrus in mice.
three DNA methyltransferases, Dnmt1, Dnmt3a (show DNMT3A Antibodies), and Dnmt3b (show DNMT3B Antibodies), have been identified. Dnmt3a (show DNMT3A Antibodies) and Dnmt3b (show DNMT3B Antibodies) are responsible for establishing DNA methylation (show HELLS Antibodies) patterns produced through their de novo-type DNA methylation (show HELLS Antibodies) activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l (show TRDMT1 Antibodies)), which is a member of the Dnmt3 family but does not possess DNA methylation (show HELLS Antibodies)
While lens epithelial cell survival requires DNMT1, morphologically normal lenses develop in the absence of both DNMT3A (show DNMT3A Antibodies) and DNMT3B (show DNMT3B Antibodies).
Our results provide insights into the molecular basis of DNMT1 dysfunction in hereditary sensory and autonomic neuropathies with dementia and hearing loss patients and emphasize the importance of the TS domain in the regulation of DNA methylation (show HELLS Antibodies) in pluripotent and differentiating cells
miR (show MLXIP Antibodies)-29a mimic transfection lowered collagen 1alpha1, DNMT1, DNMT3b (show DNMT3B Antibodies) and SET1A (show SETD1A Antibodies) expression in hepatic stellate cells.
These results demonstrate that Dnmt1 and Dnmt3b (show DNMT3B Antibodies) cooperate to maintain DNA methylation (show HELLS Antibodies) and genomic integrity in the intestinal epithelium.
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
DNA (cytosine-5)-methyltransferase 1
, CXXC-type zinc finger protein 9
, DNA MTase HsaI
, DNA methyltransferase HsaI
, DNA methyltransferase 1
, DNA (cytosine 5 ) methyltransferase 1
, DNA methyltransferase (cytosine 5 ) methyltransferase
, DNA methyltransferase b
, DNA MTase RnoIP
, DNA methyltransferase (cytosine-5) 1
, DNA methyltransferase I
, DNA MTase GgaI
, DNA MeTase
, DNA methyltransferase GgaI
, DNA MTase MmuI
, DNA methyltransferase MmuI