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anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Antibodies

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Additionally we are shipping DNA (Cytosine-5)-Methyltransferase 1 Kits (24) and DNA (Cytosine-5)-Methyltransferase 1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DNMT1 1786 P26358
DNMT1 84350  
DNMT1 13433 P13864
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Top anti-DNA (Cytosine-5)-Methyltransferase 1 Antibodies at antibodies-online.com

Showing 10 out of 426 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Goat Un-conjugated EIA, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated EIA 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of DNMT1 Antibody (S1105) (ABIN387879) in MDA-MB435 cell line lysates (35 µg/lane). DNMT1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-Dnmt1 Phospho-specific Pab (ABIN389901) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, WB The anti-Dnmt1 C-term Pab (ABIN387878) is used in Western blot to detect Dnmt1 in Jurkat cell lysate. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-Phospho-Dnmt1-pS154 Antibody (ABIN389917) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Fish Mouse Un-conjugated ChIP, IP, IHC, WB Dnmt1, 18ug H1299 lysate 1 in1000 Western Blotting. 100 μg Log in to see 3 to 4 Days
$383.90
Details
Fish Mouse Un-conjugated ChIP, IP, IHC, WB Dnmt1, 18ug H1299 lysate 1 in1000 Western Blotting. 100 μg Log in to see 3 to 4 Days
$383.90
Details

DNMT1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-DNA (Cytosine-5)-Methyltransferase 1 Antibodies

  1. Human Polyclonal DNMT1 Primary Antibody for FACS, WB - ABIN387878 : Peterson, Bögler, Taylor: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. in Cancer research 2003 (PubMed)
    Show all 7 references for ABIN387878

  2. Human Polyclonal DNMT1 Primary Antibody for WB - ABIN387879 : Leu, Rahmatpanah, Shi, Wei, Liu, Yan, Huang: Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. in Cancer research 2003 (PubMed)
    Show all 7 references for ABIN387879

  3. Fish Monoclonal DNMT1 Primary Antibody for ChIP, IP - ABIN361726 : Bestor, Laudano, Mattaliano, Ingram: Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. in Journal of molecular biology 1989 (PubMed)
    Show all 6 references for ABIN361726

  4. Fish Monoclonal DNMT1 Primary Antibody for ChIP, IP - ABIN1027706 : Yen, Vertino, Nelkin, Yu, el-Deiry, Cumaraswamy, Lennon, Trask, Celano, Baylin: Isolation and characterization of the cDNA encoding human DNA methyltransferase. in Nucleic acids research 1992 (PubMed)
    Show all 6 references for ABIN1027706

  5. Human Polyclonal DNMT1 Primary Antibody for EIA, WB - ABIN356564 : Saito, Kanai, Nakagawa, Sakamoto, Saito, Ishii, Hirohashi: Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. in International journal of cancer. Journal international du cancer 2003 (PubMed)
    Show all 6 references for ABIN356564

  6. Human Polyclonal DNMT1 Primary Antibody for DB - ABIN389901 : Siedlecki, Garcia Boy, Comagic, Schirrmacher, Wiessler, Zielenkiewicz, Suhai, Lyko: Establishment and functional validation of a structural homology model for human DNA methyltransferase 1. in Biochemical and biophysical research communications 2003 (PubMed)
    Show all 5 references for ABIN389901

  7. Human Polyclonal DNMT1 Primary Antibody for EIA - ABIN358447 : Yang, Andrade, Labialle, Moussette, Geneau, Sinnett, Belisle, Greenwood, Naumova: Parental effect of DNA (Cytosine-5) methyltransferase 1 on grandparental-origin-dependent transmission ratio distortion in mouse crosses and human families. in Genetics 2008 (PubMed)
    Show all 2 references for ABIN358447

  8. Human Polyclonal DNMT1 Primary Antibody for EIA - ABIN358462 : Liao, Siu, Chan, Wong, Ngan, Chan, Li, Khoo, Cheung: Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis. in International journal of cancer. Journal international du cancer 2008 (PubMed)
    Show all 2 references for ABIN358462

  9. Human Polyclonal DNMT1 Primary Antibody for DB - ABIN389917 : Dion, Lin, Hubert, Waterland, Wilson: Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline. in Human molecular genetics 2008 (PubMed)
    Show all 2 references for ABIN389917

More Antibodies against DNA (Cytosine-5)-Methyltransferase 1 Interaction Partners

Zebrafish DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Dnmt1 stability requires UHRF1 (show UHRF1 Antibodies) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation

  2. Lsh (show HELLS Antibodies) Is Essential for Maintaining Global DNA Methylation (show HELLS Antibodies) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.

  3. Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (show CEBPA Antibodies) regulation during definitive hematopoiesis in zebrafish

  4. These data provide the first evidence that Uhrf1 (show UHRF1 Antibodies) and Dnmt1 function is required for vertebrate lens development and maintenance.

  5. These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (show SUV39H1 Antibodies) and that, together, Dnmt1 and Suv39h1 (show SUV39H1 Antibodies) help guide the terminal differentiation of particular tissues.

  6. Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.

  7. Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.

Human DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. In mammals, DNA methylation (show HELLS Antibodies) is introduced by the DNMT1, DNMT3A (show DNMT3A Antibodies), and DNMT3B (show DNMT3B Antibodies) enzymes, which are all large multi-domain proteins. These enzymes contain a catalytic C-terminal domain with a characteristic cytosine-C5 methyltransferase fold and an N-terminal part with different domains that interacts with other proteins and chromatin and is involved in targeting and regulation of the DNMTs

  2. A feedback loop between miR (show MLXIP Antibodies)-30a-5p/miR (show MLXIP Antibodies)-30c-5p and DNMT1 is a potent signature for cisplatin-resistance and epithelial-mesenchymal transition in ovarian cancer.

  3. TLR9 (show TLR9 Antibodies) upregulation in cases with episomal HPV16 was again higher among those with non-methylated immunostimulatory CpG motifs. Comparison of cases with HPV-negative controls revealed that DNMT3A (show DNMT3A Antibodies) was significantly downregulated only among integrated cases, DNMT3B (show DNMT3B Antibodies) was significantly overexpressed among both categories of cases, although at variable levels, while DNMT1 failed to show any deregulated expression among the cases

  4. age affects the expression of DNMT1 and DNMT3B (show DNMT3B Antibodies) as an almost independent variable in respect of all other variables evaluated.

  5. Participants with the high-risk genotype of DNMT1 rs8101626 and DNMT3A (show DNMT3A Antibodies) rs34048824 with concurrently high urinary total arsenic levels had even higher OR of clear cell renal cell carcinoma (show MOK Antibodies) in a dose-response manner

  6. DNMT1 is negatively associated with miR (show MLXIP Antibodies)-211 expression in melanoma cells.MiR-211 is epigenetically regulated by DNMT1 mediated methylation.

  7. DNMT1 down regulation mediated upregulation of CDH1 (show CDH1 Antibodies) (hereafter, DNMT1/CDH1 (show CDH1 Antibodies) loop) in presence of ectopic-excess of miR (show MLXIP Antibodies)-152 prevents migration of cancer cells.

  8. Our results provide insights into the molecular basis of DNMT1 dysfunction in hereditary sensory and autonomic neuropathies with dementia and hearing loss patients and emphasize the importance of the TS domain in the regulation of DNA methylation (show HELLS Antibodies) in pluripotent and differentiating cells

  9. the ability of TGF-beta1 (show TGFB1 Antibodies) to increase expression of both DNMT1 and DNMT3a (show DNMT3A Antibodies) demonstrates a novel means by which TGF-beta1 (show TGFB1 Antibodies) may regulate DNA methylation (show HELLS Antibodies) in these cells.

  10. Sequence analysis results of a family with a family with adult-onset autosomal dominant cerebellar ataxia (show USP14 Antibodies) with deafness and narcolepsy identified a variant, NM_001130823.1:c.1709C>T [p.Ala570Val], in DNMT1 gene which was segregated with the disease within the family. These findings provide evidence that this heterozygous variant is likely disease-causing pathogenesis.

Pig (Porcine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.

  2. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (show DNMT3A Antibodies), Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 (show UHRF1 Antibodies) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

  3. DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm (show NLRP5 Antibodies) cortex of oocytes and cytoplasm of early embryos.

  4. results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos

  5. Oocyte-specific Dnmt1 is cytoplasmic during early development.

  6. Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.

Cow (Bovine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. DNMT1 silencing significantly decreased the methylation levels of miR (show MYLIP Antibodies)-29b promoter, up-regulated miR (show MYLIP Antibodies)-29b expression and inhibited bovine viral diarrhea virus replication.

  2. Through down-regulating the expression of DNMT1, miR (show MYLIP Antibodies)-152 reduced Global DNA methylation (show HELLS Antibodies) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (show AKT1 Antibodies) and Ppar gamma (show PPARG Antibodies).

  3. More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (show ASCL2 Antibodies) mRNA was present at highest levels in transgenic SCNT embryos.

  4. Our results indicate an essential role for Dnmt1 during bovine preimplantation development (show MTA2 Antibodies), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.

  5. Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos

  6. Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.

  7. Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.

  8. Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.

Arabidopsis thaliana DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis

  2. Met1 gene expression throughout normal development, particularly in the flower

  3. MET1 is a contributor to epigenetic diversity in Arabidopsis.

  4. VIM (show VIM Antibodies) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (show HELLS Antibodies) and histone modification status in collaboration with MET1

  5. VIM (show VIM Antibodies) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (show HELLS Antibodies) pathway.

  6. Genetic studies indicate that the Polycomb (show CBX2 Antibodies) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]

  7. MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.

  8. There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation (show HELLS Antibodies) in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.

  9. Our results bear interesting similarities with cancer cells, which show global losses of DNA methylation (show HELLS Antibodies) but ectopic hypermethylation of genes previously marked by H3K27m3.

  10. An intergenic nucleosome-free crossover hotspot 3a undergoes increased recombination activity in met1.

Mouse (Murine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. three DNA methyltransferases, Dnmt1, Dnmt3a (show DNMT3A Antibodies), and Dnmt3b (show DNMT3B Antibodies), have been identified. Dnmt3a (show DNMT3A Antibodies) and Dnmt3b (show DNMT3B Antibodies) are responsible for establishing DNA methylation (show HELLS Antibodies) patterns produced through their de novo-type DNA methylation (show HELLS Antibodies) activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l (show TRDMT1 Antibodies)), which is a member of the Dnmt3 family but does not possess DNA methylation (show HELLS Antibodies)

  2. While lens epithelial cell survival requires DNMT1, morphologically normal lenses develop in the absence of both DNMT3A (show DNMT3A Antibodies) and DNMT3B (show DNMT3B Antibodies).

  3. Our results provide insights into the molecular basis of DNMT1 dysfunction in hereditary sensory and autonomic neuropathies with dementia and hearing loss patients and emphasize the importance of the TS domain in the regulation of DNA methylation (show HELLS Antibodies) in pluripotent and differentiating cells

  4. miR (show MLXIP Antibodies)-29a mimic transfection lowered collagen 1alpha1, DNMT1, DNMT3b (show DNMT3B Antibodies) and SET1A (show SETD1A Antibodies) expression in hepatic stellate cells.

  5. These results demonstrate that Dnmt1 and Dnmt3b (show DNMT3B Antibodies) cooperate to maintain DNA methylation (show HELLS Antibodies) and genomic integrity in the intestinal epithelium.

  6. DNMT1 mRNA expression was significantly decreased in the isocortex but significantly increased in the prefrontal following hyperoxia

  7. Cigarette smoke induces proteosomal-mediated degradation of DNMT1 in embryonic orofacial cells.

  8. the abundance of BDNF (show BDNF Antibodies) positively correlated and phosphorylated DNMT1 inversely correlated with that of FKBP51 (show FKBP5 Antibodies) in cells

  9. we suggest that 14-3-3 (show YWHAQ Antibodies) is a crucial reader of DNMT1pSer143 that regulates DNA methylation (show HELLS Antibodies) and altered gene expression that contributes to cell invasion

  10. The replication foci targeting sequence domain, not the proliferating cell nuclear antigen (show PCNA Antibodies) - binding domain, is solely responsible for the replication-coupled DNA methylation (show HELLS Antibodies).

DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Antigen Profile

Protein Summary

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DNMT1

  • DNA (cytosine-5-)-methyltransferase 1 (DNMT1) antibody
  • DNA (cytosine-5-)-methyltransferase 1 (dnmt1) antibody
  • DNA (cytosine-5-)-methyltransferase 1 (Dnmt1) antibody
  • DNA (cytosine-5)-methyltransferase 1 (MET1) antibody
  • DNA methyltransferase (cytosine-5) 1 (Dnmt1) antibody
  • ADCADN antibody
  • AIM antibody
  • cb983 antibody
  • cb1075 antibody
  • Cxxc9 antibody
  • DDM2 antibody
  • DECREASED DNA METHYLATION 2 antibody
  • dmnt1 antibody
  • DMT01 antibody
  • DMT1 antibody
  • DNA METHYLTRANSFERASE antibody
  • DNA METHYLTRANSFERASE 01 antibody
  • DNA METHYLTRANSFERASE 1 antibody
  • Dnmt antibody
  • Dnmt1o antibody
  • fb05h01 antibody
  • HSN1E antibody
  • m.MmuI antibody
  • MCMT antibody
  • Met-1 antibody
  • Met1 antibody
  • MET2 antibody
  • methyltransferase 1 antibody
  • METHYLTRANSFERASE 2 antibody
  • METHYLTRANSFERASE I antibody
  • METI antibody
  • MommeD2 antibody
  • mta antibody
  • MTase antibody
  • wu:fb05h01 antibody

Protein level used designations for DNMT1

DNA (cytosine-5)-methyltransferase 1 , ddn , CXXC-type zinc finger protein 9 , DNA MTase HsaI , DNA methyltransferase HsaI , m.HsaI , DNA methyltransferase 1 , DNA (cytosine 5 ) methyltransferase 1 , DNA methyltransferase (cytosine 5 ) methyltransferase , DNA methyltransferase b , DNA MTase RnoIP , DNA methyltransferase (cytosine-5) 1 , DNA methyltransferase I , MCMT , m.RnoIP , DNA MTase GgaI , DNA MeTase , DNA methyltransferase GgaI , m.GgaI , DNA MTase MmuI , DNA methyltransferase MmuI

GENE ID SPECIES
443549 Ovis aries
30430 Danio rerio
1786 Homo sapiens
476715 Canis lupus familiaris
606746 Sus scrofa
281119 Bos taurus
84350 Rattus norvegicus
396011 Gallus gallus
834975 Arabidopsis thaliana
13433 Mus musculus
Selected quality suppliers for anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Antibodies
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