Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3A Antibodies (273) and DNMT3A Kits (2) and many more products for this protein.
Showing 5 out of 6 products:
Human DNMT3A Protein expressed in HEK-293 Cells - ABIN2719617
Cree, Fredericks, Miller, Pearce, Filichev, Fee, Kennedy: DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. in FEBS letters 2016
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Proteins), Dnmt3a, Hdac1 (show HDAC1 Proteins), Kdm3a (show KDM3A Proteins) and Uhrf1 (show UHRF1 Proteins) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
alterations in DNMT3A and TET2 may be associated with acute myeloid leukemia (show BCL11A Proteins) prognosis
Mutation in the DNMT3A gene is associated with acute myeloid leukemia (show BCL11A Proteins) patients with lympho-myeloid clonal hematopoiesis.
These data demonstrate that haploinsufficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malignancies by a mechanism that is not yet clear.
This report represents the first documentation of the same variant (DNMT3A p.Arg882His) as both the constitutional mutation associated with TBRS and the somatic mutation hotspot of AML (show RUNX1 Proteins).
Significantly lower DNMT1 (show DNMT1 Proteins) and DNMT3A transcript levels in systemic lupus erythematosus patients were observed compared with healthy controls.
Mutations in genes associated with epigenetic regulations such as DNMT3A and ASXL1 (show ASXL1 Proteins) seem to play an important role in the pathogenesis of CML (show BCR Proteins) progression and TKI-resistance independent of ABL1 (show ABL1 Proteins) KD mutations
Dnmt3a2 is at the core of memory processes and represents a novel target for cognition-enhancing therapies to ameliorate anxiety and fear disorders and boost memory consolidation.
Data indicate that DNMT3A allele G of rs1550117 was associated with an increased risk of non-small cell lung cancer (NSCLC) susceptibility and binding affinity of transcription repressor SP1 (show PSG1 Proteins).
The results show that DNMT3A mutations are associated with an unfavourable clinical outcome in our Southeast Asian AML (show RUNX1 Proteins) patient cohort.
DNMT3A mutations were rare in Chinese children with acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)). The mutation positions were different from the hotspots reported in adult AML (show RUNX1 Proteins). DNMT3A mutations may have adverse impact on prognosis of children with AML (show RUNX1 Proteins).
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Proteins) content are rather a function of time, and not a genetic component.
The effect of p53 (show TP53 Proteins) expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Proteins) and DNMT3A are reported.
The expression levels of DNMT3a and DNMT3b (show DNMT3B Proteins) were associated with several beef quality traits.
Loss of DNMT3A expression is associated with development of malignancy.
confirm the transformation potential of DNMT3A(R882H) Tet2(-/-) progenitors and represent the first cooperative model in mice involving Tet2 inactivation driving lymphoid malignancies
overexpression of Dnmt3a partially rescued the impairment of adipogenesis induced by AP2alpha (show TFAP2A Proteins) knockdown.
These data show that DNMT3a plays an important role in regulating embryonic cardiomyocyte gene expression, morphology and function.
in addition to the established role of Dnmt3a in regulating self-renewal, Dnmt3a regulates tissue tropism and limits myeloid progenitor expansion in vivo.
Dnmt3a mutations induced hematopoietic stem cell expansion, cooperated with mutations in the FMS-like tyrosine kinase 3 (show FLT3 Proteins) gene (Flt3 (show FLT3 Proteins)(ITD)) and the nucleophosmin (show NPM1 Proteins) gene (Npm1 (show GJA1 Proteins)(c)) to induce AML (show RUNX1 Proteins) in vivo, and promoted resistance to anthracycline chemotherapy.
miR (show MLXIP Proteins)-29a/b/c repressed DNMT3A expression by directly targeting its 3' untranslated region (3' UTR). Our data reveal a novel mechanism of miR (show MLXIP Proteins)-29a/b/c in the regulation of adipogenesis
DOT1L (show DOT1L Proteins) may play a critical role in DNMT3A-mutant leukemia.
Thyroid regulation of Dnmt3a may be an evolutionarily conserved mechanism for modulating global changes in DNA methylation (show HELLS Proteins) during postnatal neurological development.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
DNA (cytosine-5-)-methyltransferase 3 alpha
, DNA cytosine methyltransferase 3 alpha
, DNA (cytosine-5)-methyltransferase 3A
, DNA methyl transferase alpha
, DNA methyltransferase 3A
, DNA MTase HsaIIIA
, DNA cytosine methyltransferase 3A2
, DNA-methyltransferase 3a
, DNA MTase MmuIIIA
, DNA methyltransferase MmuIIIA