DNA (Cytosine-5-)-Methyltransferase 3 alpha Proteins (DNMT3A)

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3A Antibodies (273) and DNMT3A Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DNMT3A 1788 Q9Y6K1
Rat DNMT3A DNMT3A 444984 Q1LZ53
DNMT3A 13435 O88508
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Top DNMT3A Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Bioactivity measured with Activity Assay Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
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HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$365.64
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DNMT3A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Top referenced DNMT3A Proteins

  1. Human DNMT3A Protein expressed in HEK-293 Cells - ABIN2719617 : Cree, Fredericks, Miller, Pearce, Filichev, Fee, Kennedy: DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. in FEBS letters 2016 (PubMed)

More Proteins for DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaction Partners

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Proteins), Dnmt3a, Hdac1 (show HDAC1 Proteins), Kdm3a (show KDM3A Proteins) and Uhrf1 (show UHRF1 Proteins) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Human DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. alterations in DNMT3A and TET2 may be associated with acute myeloid leukemia (show BCL11A Proteins) prognosis

  2. Mutation in the DNMT3A gene is associated with acute myeloid leukemia (show BCL11A Proteins) patients with lympho-myeloid clonal hematopoiesis.

  3. These data demonstrate that haploinsufficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malignancies by a mechanism that is not yet clear.

  4. This report represents the first documentation of the same variant (DNMT3A p.Arg882His) as both the constitutional mutation associated with TBRS and the somatic mutation hotspot of AML (show RUNX1 Proteins).

  5. Significantly lower DNMT1 (show DNMT1 Proteins) and DNMT3A transcript levels in systemic lupus erythematosus patients were observed compared with healthy controls.

  6. Mutations in genes associated with epigenetic regulations such as DNMT3A and ASXL1 (show ASXL1 Proteins) seem to play an important role in the pathogenesis of CML (show BCR Proteins) progression and TKI-resistance independent of ABL1 (show ABL1 Proteins) KD mutations

  7. Dnmt3a2 is at the core of memory processes and represents a novel target for cognition-enhancing therapies to ameliorate anxiety and fear disorders and boost memory consolidation.

  8. Data indicate that DNMT3A allele G of rs1550117 was associated with an increased risk of non-small cell lung cancer (NSCLC) susceptibility and binding affinity of transcription repressor SP1 (show PSG1 Proteins).

  9. The results show that DNMT3A mutations are associated with an unfavourable clinical outcome in our Southeast Asian AML (show RUNX1 Proteins) patient cohort.

  10. DNMT3A mutations were rare in Chinese children with acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)). The mutation positions were different from the hotspots reported in adult AML (show RUNX1 Proteins). DNMT3A mutations may have adverse impact on prognosis of children with AML (show RUNX1 Proteins).

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Proteins) content are rather a function of time, and not a genetic component.

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. The effect of p53 (show TP53 Proteins) expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Proteins) and DNMT3A are reported.

  2. The expression levels of DNMT3a and DNMT3b (show DNMT3B Proteins) were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. These data demonstrate that haploinsufficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malignancies by a mechanism that is not yet clear.

  2. Loss of DNMT3A expression is associated with development of malignancy.

  3. confirm the transformation potential of DNMT3A(R882H) Tet2(-/-) progenitors and represent the first cooperative model in mice involving Tet2 inactivation driving lymphoid malignancies

  4. overexpression of Dnmt3a partially rescued the impairment of adipogenesis induced by AP2alpha (show TFAP2A Proteins) knockdown.

  5. These data show that DNMT3a plays an important role in regulating embryonic cardiomyocyte gene expression, morphology and function.

  6. in addition to the established role of Dnmt3a in regulating self-renewal, Dnmt3a regulates tissue tropism and limits myeloid progenitor expansion in vivo.

  7. Dnmt3a mutations induced hematopoietic stem cell expansion, cooperated with mutations in the FMS-like tyrosine kinase 3 (show FLT3 Proteins) gene (Flt3 (show FLT3 Proteins)(ITD)) and the nucleophosmin (show NPM1 Proteins) gene (Npm1 (show GJA1 Proteins)(c)) to induce AML (show RUNX1 Proteins) in vivo, and promoted resistance to anthracycline chemotherapy.

  8. miR (show MLXIP Proteins)-29a/b/c repressed DNMT3A expression by directly targeting its 3' untranslated region (3' UTR). Our data reveal a novel mechanism of miR (show MLXIP Proteins)-29a/b/c in the regulation of adipogenesis

  9. DOT1L (show DOT1L Proteins) may play a critical role in DNMT3A-mutant leukemia.

  10. Thyroid regulation of Dnmt3a may be an evolutionarily conserved mechanism for modulating global changes in DNA methylation (show HELLS Proteins) during postnatal neurological development.

DNMT3A Protein Profile

Protein Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with DNMT3A

  • DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A)
  • DNA methyltransferase 3A (dnmt3a)
  • DNA (cytosine-5-)-methyltransferase 3 alpha (Dnmt3a)
  • DNA methyltransferase 3A (Dnmt3a)
  • DNMT3A protein
  • DNMT3A2 protein
  • M.HsaIIIA protein
  • MmuIIIA protein

Protein level used designations for DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha , DNA cytosine methyltransferase 3 alpha , DNA (cytosine-5)-methyltransferase 3A , DNA methyl transferase alpha , DNA methyltransferase 3A , DNA MTase HsaIIIA , DNA cytosine methyltransferase 3A2 , DNA-methyltransferase 3a , DNA MTase MmuIIIA , DNA methyltransferase MmuIIIA

GENE ID SPECIES
482996 Canis lupus familiaris
694822 Macaca mulatta
739139 Pan troglodytes
100037301 Sus scrofa
100030681 Monodelphis domestica
100344715 Oryctolagus cuniculus
100500776 Ovis aries
100594618 Nomascus leucogenys
100529107 Anolis carolinensis
1788 Homo sapiens
421991 Gallus gallus
100510798 Felis catus
100055881 Equus caballus
359716 Bos taurus
444984 Rattus norvegicus
13435 Mus musculus
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