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DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) Proteins (DRAP1)

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Additionally we are shipping DRAP1 Antibodies (49) and DRAP1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DRAP1 66556 Q9D6N5
DRAP1 293674 A0JPP1
DRAP1 10589 Q14919
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Top DRAP1 Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) (DRAP1) (AA 4-198), (partial) protein (GST tag) 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,498.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,498.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DRAP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
,

Top referenced DRAP1 Proteins

  1. Human DRAP1 Protein expressed in Escherichia coli (E. coli) - ABIN1046948 : Goppelt, Stelzer, Lottspeich, Meisterernst: A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains. in The EMBO journal 1996 (PubMed)
    Show all 3 references for ABIN1046948

More Proteins for DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) (DRAP1) Interaction Partners

Human DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) (DRAP1) interaction partners

  1. physical cooperation between BTAF1 and NC2alpha in TBP (show TBP Proteins) regulation

  2. The global distribution of DRAP1 on promoters was determined.

  3. provide evidence that negative cofactor-2 (NC2 (show GTF2H5 Proteins)) induces dynamic conformational changes in the TBP (show TBP Proteins)-DNA complex that allow it to escape and return to TATA-binding mode

  4. heterodimerization with NC2alpha masks the nuclear localization signal in NC2beta (show DR1 Proteins), which prevents nuclear export of the NC2 (show GTF2H5 Proteins) complex

DRAP1 Protein Profile

Protein Summary

Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.

Gene names and symbols associated with DRAP1

  • DR1-associated protein 1 (negative cofactor 2 alpha) (drap1)
  • DR1-associated protein 1 (negative cofactor 2 alpha) (DRAP1)
  • Dr1 associated protein 1 (negative cofactor 2 alpha) (Drap1)
  • 2310074H19Rik protein
  • DRAP1 protein
  • fb26e10 protein
  • NC2-alpha protein
  • wu:fb26e10 protein
  • zgc:56003 protein
  • zgc:77337 protein

Protein level used designations for DRAP1

dr1-associated corepressor , DR1-associated protein 1 (negative cofactor 2 alpha) , NC2-alpha , dr1-associated protein 1 , negative co-factor 2-alpha , negative cofactor 2 alpha

GENE ID SPECIES
321681 Danio rerio
476018 Canis lupus familiaris
100195180 Salmo salar
66556 Mus musculus
293674 Rattus norvegicus
10589 Homo sapiens
540345 Bos taurus
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