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Dachshund Homolog 1 (Drosophila) Proteins (DACH1)

DACH1 encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. Additionally we are shipping DACH1 Antibodies (68) and DACH1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DACH1 13134 Q9QYB2
DACH1 1602 Q9UI36
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Top DACH1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

DACH1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Dachshund Homolog 1 (Drosophila) (DACH1) Interaction Partners

Mouse (Murine) Dachshund Homolog 1 (Drosophila) (DACH1) interaction partners

  1. The results of this study suggested the involvement of the mouse Dach1 gene in adult neurogenesis; cells expressing this gene exhibit the properties of adult NSCs or neuroblasts and respond to MCAo by enhanced neurogenesis.

  2. find that in cells growin (show IGF1 Proteins)g in IGF-1 (and unrespons (show EGF Proteins)ive to EGF), DACH1 is devoid of tumor suppressor activity

  3. The mouse dachshund gene is related to the Ski (show SKI Proteins) proto-oncogene (show RAB1A Proteins) and is expressed in eye and limb.

  4. In the mouse, Dach1 expression in the developing ear also overlaps with the expression of Eya1 (show EYA1 Proteins) (an eya homologue)

  5. Dach1 is a target gene of FGF signaling during limb skeletal development, and Dach1 may function as an intermediary in the FGF signaling pathway regulating cell proliferation or differentiation

  6. Dach1 is critical for postnatal survival of mice

  7. The phosphatase function of Eya switches the function of Six1 (show SIX1 Proteins)-Dach from repression to activation, causing transcriptional activation through recruitment of co-activators

  8. The Pax (show PXN Proteins)-Eya-Six-Dach network is at best only partly conserved during lens and nasal placode development.

  9. DACH1 repressed cyclin D1 (show CCND1 Proteins) through a novel mechanism via a c-Jun (show JUN Proteins) DNA-binding partner, requiring the DACH1 alpha-helical DS domain which recruits corepressors to the local chromatin.

  10. These studies demonstrate a novel mechanism by which DACH1 blocks c-Jun (show JUN Proteins)-mediated contact-independent growth through repressing the c-Jun (show JUN Proteins) delta domain.

Human Dachshund Homolog 1 (Drosophila) (DACH1) interaction partners

  1. Kaplan-Mier analysis of human NSCLC samples demonstrated that high DACH1 mRNA levels predicted favorable prognosis for relapse-free and overall survival. In agreement, high CXCL5 (show CXCL5 Proteins) expression predicted a worse prognosis for survival.

  2. DACH1 expression was reduced in hepatocellular carcinoma even at early stage and associated with tumor progression. Overexpression inhibited HCC (show FAM126A Proteins) cell growth and migration by inactivating the Wnt (show WNT2 Proteins) pathway via GSK3beta phosphorylation to suppress beta-catenin (show CTNNB1 Proteins).

  3. In breast cancer, some GATA3 (show GATA3 Proteins) effects shift from tumor suppressing to tumor promoting during tumorigenesis, with deregulation of three genes, BCL2 (show BCL2 Proteins), DACH1, THSD4 (show THSD4 Proteins), representing major GATA3 (show GATA3 Proteins)-controlled processes in cancer progression.

  4. Results indicated that DACH1 was a novel molecular marker of RCC (show XRCC1 Proteins) and it attributed to the malignant behavior of renal cancer cells.

  5. Data indicate that dachshund family transcription factor 1 (show HNF1A Proteins) (DACH1) suppresses gastric cancer cell proliferation, invasion and metastasis by inhibiting transforming growth factor beta (TGF-beta) signalling pathways both in vitro and in vivo.

  6. results suggest that DACH1 loss of function results in increased cell growth, motility and invasiveness through TGF-beta (show TGFB1 Proteins)-mediated EMT (show ITK Proteins), and DACH1 loss of function has important therapeutic implications for targeted therapies of CRC (show CALR Proteins)

  7. DACH1 is a determinant of benign and malignant prostate epithelium cellular growth, migration, and cytokine abundance in vivo.

  8. Further evaluation of the methylation of DACH1, DKK1 (show DKK1 Proteins), and WIF1 (show WIF1 Proteins) in a clinical patient group confirmed the frequent methylation of WIF1 (show WIF1 Proteins) and intermediate or low frequency of methylation of DACH1 or DKK1 (show DKK1 Proteins), respectively.

  9. DACH1 inhibits aldosterone secretion in human adrenals, and transforming growth factor-beta signaling pathway is activated in DACH1 overexpressed cells and may mediate inhibition of aldosterone secretion in human adrenals.

  10. Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese

DACH1 Protein Profile

Protein Summary

This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DACH1

  • dachshund homolog 1 (Drosophila) (DACH1)
  • dachshund homolog 1 (dach1)
  • dachshund d (dachd)
  • dachshund homolog 1 (Drosophila) (dach1)
  • dachshund 1 (Drosophila) (Dach1)
  • AI182278 protein
  • Dac protein
  • DACH protein
  • E130112M23Rik protein
  • zgc:158869 protein

Protein level used designations for DACH1

dachshund homolog 1 (Drosophila) , dachshund homolog 1 , dachshund 1 , dachshund protein , dachshund homolog 1-like

GENE ID SPECIES
467281 Pan troglodytes
779068 Xenopus laevis
779442 Xenopus (Silurana) tropicalis
791191 Danio rerio
100303544 Saccoglossus kowalevskii
693532 Macaca mulatta
100010972 Monodelphis domestica
100224395 Taeniopygia guttata
100466304 Ailuropoda melanoleuca
100550020 Meleagris gallopavo
100553703 Anolis carolinensis
100595110 Nomascus leucogenys
13134 Mus musculus
1602 Homo sapiens
485489 Canis lupus familiaris
100156238 Sus scrofa
373935 Gallus gallus
100065685 Equus caballus
537184 Bos taurus
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