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Potential guanine nucleotide exchange factor (GEF).
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T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms
Dock10 could represent a point of convergence for interleukin 4 (show IL4 Antibodies) signalling and small Rho GTPase (show RACGAP1 Antibodies) function in B cells.
Silencing DOCK10 expression in melanoma promotes conversion to mesenchymal migration and is associated with decreased MLC2 phosphorylation and increased Rac1 activation.
DOCK10 function in dendritic spine morphogenesis is mediated mainly by Cdc42 and its downstream effectors N-WASP and PAK3, although DOCK10 is also able to activate Rac1.
Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP.
dedicator of cytokinesis protein 10
, dedicator of cytokinesis 10
, dedicator of cytokinesis protein 10-like
, dopamine receptor interacting protein 2
, protein zizimin 3