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Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. Additionally we are shipping Defensin, alpha 5, Paneth Cell-Specific Kits (54) and Defensin, alpha 5, Paneth Cell-Specific Proteins (5) and many more products for this protein.
Showing 10 out of 56 products:
Human Monoclonal DEFA5 Primary Antibody for DB, ICC - ABIN258712
Wehkamp, Salzman, Porter, Nuding, Weichenthal, Petras, Shen, Schaeffeler, Schwab, Linzmeier, Feathers, Chu, Lima, Fellermann, Ganz, Stange, Bevins: Reduced Paneth cell alpha-defensins in ileal Crohn's disease. in Proceedings of the National Academy of Sciences of the United States of America 2005
Show all 9 Pubmed References
Human Monoclonal DEFA5 Primary Antibody for IA, IHC (fro) - ABIN2192079
Kelly, Bajaj-Elliott, Katubulushi, Zulu, Poulsom, Feldman, Bevins, Dhaliwal: Reduced gene expression of intestinal alpha-defensins predicts diarrhea in a cohort of African adults. in The Journal of infectious diseases 2006
Show all 3 Pubmed References
Human Polyclonal DEFA5 Primary Antibody for IHC, IHC (p) - ABIN4304804
Lee, Nam, Park, Kim, Lafleur, Aburatani, Yang, Kim, Goldenring: Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer. in Gastroenterology 2010
Human alpha-Defensin-5 is a potential candidate biomarker to molecularly differentiate Crohn's colitis from ulcerative colitis, to our knowledge. These data give us both a potential diagnostic marker in Human alpha-Defensin-5 and insight to develop future mechanistic studies to better understand crypt biology in Crohn's colitis.
Different dynamics and pathway of disulfide bonds reduction has been demonstrated for two human defensins, HD5 and HBD-3 (show DEFB103A Antibodies).
Human adenovirus 3 produces large amounts of penton-dodecahedra (PtDd), virus-like particles, during replication, which also function in blocking of HD5.
no biologic differences between wild-type HD5 and its variants were observed on HD5 antibacterial activity against Escherichia coli
a moderately active linear peptide derived from the alpha-defensin (show DEF Antibodies) HD5 can be engineered to enhance antimicrobial activity almost comparable to the native peptide.
The study used ion mobility coupled to mass spectrometry to track the structural changes in HD-5 upon disulfide bond reduction.
The study reports the screening of human defensin 5 against the Keio Collection of E. coli strains and shows how this important hostdefense peptide kills bacteria and how bacteria protect themselves against the attack from the human host.
Authors show that although NOD2 (show NOD2 Antibodies) by itself can slightly up-regulate expression of HD5 and HD6 (show DEFA6 Antibodies), it can strongly down-regulates their expression during differentiation of the Paneth cell lineage mainly by inhibiting activation of the MAPK (show MAPK1 Antibodies) pathway.
These data support a model in which HD5 prevents furin (show FURIN Antibodies) from accessing human papillomavirus 16 L2 by occluding the furin (show FURIN Antibodies) cleavage site via direct binding to the viral capsid.
Enteric alpha-defensin (show DEF Antibodies) HD5 and beta-defensin (show DEFB1 Antibodies) hBD2 (show DEFB4 Antibodies) shared similar toxin-unfolding effects with HNP1 (show DEFA1 Antibodies), albeit to different degrees.
alpha-defensin 5 expression can also be regulated by microbial metabolites
Data show that DEFA5-expressing mice had striking losses of segmented filamentous bacteria and fewer interleukin 17 (IL-17 (show IL17A Antibodies))-producing lamina propria T cells.
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum.
, defensin 5
, defensin, alpha 5, preproprotein
, alpha-defensin 5
, defensin, alpha, 29
, defensin-related cryptdin-5
, alpha-defensin 5, Paneth cell-specific
, defensin, alpha 1
, Paneth cell-specific alpha-defensin 5
, defensin NP-2
, neutrophil antibiotic peptide NP-1
, neutrophil antibiotic peptide NP-2
, neutrophil defensin 1
, neutrophil defensin 2