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Deleted in Colorectal Carcinoma Proteins (DCC)

DCC encodes a netrin 1 receptor. Additionally we are shipping DCC Antibodies (86) and DCC Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DCC 27421 Q9R1S7
DCC 1630 P43146
DCC 25311 Q63155
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Top DCC Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 69 to 74 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 69 to 74 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

DCC Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
Human , ,
Rat (Rattus)

More Proteins for Deleted in Colorectal Carcinoma (DCC) Interaction Partners

Mouse (Murine) Deleted in Colorectal Carcinoma (DCC) interaction partners

  1. dcc haploinsufficient mice acquire intracranial self-stimulation behavior and that the parameters of the stimulation are comparable to those observed in wild-type littermates; reduced expression of dcc may dampen the abuse potential of cocaine

  2. Identified the Dcc gene as a novel downstream target of spontaneous calcium activity involved in axon growth.

  3. bisphosphonates may be helpful for prevention of mineral deposits in Pseudoxanthoma elasticum and generalized arterial calcification of infancy caused by mutations in the ABCC6 (show ABCC6 Proteins) gene.

  4. suggest that DCC signaling functions through NCK1 (show NCK1 Proteins) and NCK2 (show NCK2 Proteins) and that both proteins are necessary for the establishment of normal spinal circuits necessary for gait

  5. Results suggest that down syndrome cell adhesion molecule (show DSCAM Proteins) collaborates with deleted in colorectal cancer to regulate microtubule dynamics via direct binding to dynamic TUBB3 (show TUBB3 Proteins) in Netrin-1 (show NTN1 Proteins)-induced axon branching.

  6. In a mouse model of CKD, ABCC6 (show ABCC6 Proteins) protein expression was decreased in liver and kidney, however mRNA levels were unchanged.

  7. Data indicate the roles of Slit1 (show SLIT1 Proteins)/Robo1 (show ROBO1 Proteins) and Netrin1/DCC signals in positioning motor neuron cell bodies.

  8. These data demonstrate robust cardioprotective effect of netrin-1 (show NTN1 Proteins) in vivo, as shown by reduced infarct size and improved cardiac function mediated by netrin-1 (show NTN1 Proteins) receptor DCC.

  9. Unc5C (show Unc5c Proteins) and DCC act downstream of Ctip2 and Satb2 (show SATB2 Proteins) and contribute to corpus callosum formation.

  10. DCC appears to have a somewhat limited role in methamphetamine consumption and seeking following abstinence

Zebrafish Deleted in Colorectal Carcinoma (DCC) interaction partners

  1. Schwann cell and dcc-mediated guidance are critical early during regeneration to direct growth cones across the transection gap and onto their original axonal trajectory.

  2. in dcc mutants, turns on the inappropriate side of the body are caused by aberrant ipsilateral axonal projections

  3. Dcc-Netrin1 and roundabout2 (Robo2)-Slit coordinate axonal projection choices of neurons in the developing forebrain.

  4. Dcc regulates polarized axon initiation and asymmetric outgrowth of forebrain neurons

  5. dcc may play roles not only in axon guidance, but in morphogenesis and functioning of these organs as well

  6. First evidence that Netrin/DCC axon guidance molecules act in dendrites in a vertebrate system.

Human Deleted in Colorectal Carcinoma (DCC) interaction partners

  1. The study identified DCC as a differentially expressed gene and clustered meningiomas into DCC low expression (3 grade I and 3 grade II tumors), DCC medium expression (2 grade I and 1 grade II tumors), and DCC high expression (5 grade I tumors) groups.

  2. Data suggest that, in response to netrin-1 (show NTN1 Proteins)/netrin receptor (DCC) signaling, p120RasGAP (show RASA1 Proteins) is recruited to growth cones and supports axon outgrowth; p120RasGAP (show RASA1 Proteins) Src (show SRC Proteins) homology 2 domains exhibit scaffolding properties sufficient to support axon outgrowth.

  3. By analyzing multiple myeloma-derived cell lines and patient-derived primary CD138 (show SDC1 Proteins)-positive plasma cells ... authors show for the first time that transcriptional dysregulation of DCC is involved in the progression of plasma cell malignancy.

  4. the transfected DCC gene can suppress cell proliferation and lead to downregulation of CEA (show CEACAM5 Proteins) expression in SW1116 cells.

  5. Signaling mechanism of the netrin-1 (show NTN1 Proteins) receptor DCC in axon guidance

  6. NTN1 (show NTN1 Proteins)-DCC pathway contains targets of FDA-approved drugs and may offer promise for guiding applied clinical research on preventive and therapeutic interventions for AMD (show AMD1 Proteins)

  7. DCC mutation correlated with fractionated mirroring in individuals with Congenital mirror movements

  8. Data show that silencing ezrin-radixin-moesin (ERM (show MSN Proteins)) protein expression ablates deleted in colorectal carcinoma protein (DCC)-protein kinase A (PKA) interaction and specifically blocks netrin-induced PKA activity and phosphorylation.

  9. Migration of CD166 (show ALCAM Proteins) positive progenitor cells to sites of cartilage damage may be directed by regulation of DCC/CREB (show CREB1 Proteins) signaling.

  10. Three novel truncating mutations of DCC are associated with congenital mirror movements.

DCC Protein Profile

Protein Summary

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Gene names and symbols associated with DCC

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 6 (Abcc6)
  • deleted in colorectal carcinoma (DCC)
  • deleted in colorectal carcinoma (dcc)
  • deleted in colorectal carcinoma (Dcc)
  • Abcc1b protein
  • C030036D22Rik protein
  • CRC18 protein
  • CRCR1 protein
  • DCC protein
  • dcca-A protein
  • dyscalc protein
  • Dyscalc1 protein
  • Igdcc1 protein
  • MRMV1 protein
  • Mrp6 protein
  • xdcc protein
  • XDCCa protein
  • zdcc protein

Protein level used designations for DCC

ATP-binding cassette sub-family C member 6 , ATP-binding cassette, sub-family C, member 6 , multidrug resistance-associated protein 6 , multidrug resistance-associated protein-6 , deleted in colorectal carcinoma , netrin receptor DCC , deleted in colorectal cancer , deleted in colorectal cancer tumor suppressor , netrin receptor DCC-like , colorectal cancer suppressor , colorectal tumor suppressor , deleted in colorectal cancer protein , immunoglobulin superfamily DCC subclass member 1 , immunoglobulin superfamily, DCC subclass, member 1 , tumor suppressor protein DCC

27421 Mus musculus
455425 Pan troglodytes
483976 Canis lupus familiaris
537176 Bos taurus
569360 Danio rerio
693352 Macaca mulatta
100054013 Equus caballus
378529 Xenopus laevis
100442362 Pongo abelii
100410745 Callithrix jacchus
100556072 Anolis carolinensis
100583619 Nomascus leucogenys
1630 Homo sapiens
13176 Mus musculus
25311 Rattus norvegicus
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