anti-Desmin (DES) Antibodies

DES encodes a muscle-specific class III intermediate filament. Additionally we are shipping Desmin Kits (59) and Desmin Proteins (27) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DES 1674 P17661
DES 64362 P48675
DES 13346 P31001
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Top anti-Desmin Antibodies at antibodies-online.com

Showing 10 out of 410 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-DES Antibody Titration: </b>5.0ug/ml<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Chicken Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Desmin staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Desmin staining in human muscle formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-Desmin Antibody (t16) (ABIN389226) in NCI-H460 cell line lysates (35 µg/lane).Desmin-pT16(arrow) was detected using the purified polyclonal antibody (1:60dilution). Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cat Mouse Un-conjugated ICC, IF, MA, WB Monoclonal Anti-Desmin antibody produced in mouse 0.1 mL Log in to see 7 to 9 Days
$381.94
Details
Chicken Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat kidney tissue labeled with Anti-Desmin Polyclonal Antibody, Unconjugated (ABIN736566) at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse heart tissue labeled with Anti-Desmin Polyclonal Antibody, Unconjugated (ABIN736566) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details
Chicken Mouse Un-conjugated IF, WB Western blot analysis of desmin. Mouse muscle lysate was probed with anti-desmin (clone RD301, ABIN967294) at concentrations 0.25 (lane 1), 0.125 (lane 2), and 0.06 µg/ml (lane 3). Desmin is identified as a band of ~53 kDa. 50 μg Log in to see 6 to 8 Days
$185.43
Details
Human Rabbit Un-conjugated IHC (fro), IHC (p), WB Anti-Desmin Picoband antibody,  IHC(F): Rat Cardiac Muscle Tissue Anti-Desmin Picoband antibody,  All lanes: Anti Desmin  at 0.5ug/ml WB: Recombinant Human Desmin Protein 0.5ng Predicted bind size: 36KD Observed bind size: 36KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HeLa/HepG2 cells, using Desmin (Ab-60) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using Desmin (Ab-60) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details

DES Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Desmin Antibodies

  1. Human Monoclonal Desmin Primary Antibody for IHC (p), WB - ABIN3043640 : Jiang, Xu, Zhu, Chen, Qian, Qiao, Yang, Wang, Chen: Histological type of oncogenity and expression of cell cycle genes in tumor cells from human mesenchymal stem cells. in Oncology reports 2006 (PubMed)
    Show all 17 Pubmed References

  2. Human Polyclonal Desmin Primary Antibody for IHC (fro), IHC (p) - ABIN3043265 : Longxi, Buwu, Yuan, Sinan: Expression of p53 in the effects of artesunate on induction of apoptosis and inhibition of proliferation in rat primary hepatic stellate cells. in PLoS ONE 2011 (PubMed)
    Show all 17 Pubmed References

  3. Human Polyclonal Desmin Primary Antibody for ICC, IF - ABIN4304974 : Rasmussen, Kweon, Diekmann, Belema-Bedada, Song, Bowlin, Shi, Ferdous, Li, Kyba, Metzger, Koyano-Nakagawa, Garry: ER71 directs mesodermal fate decisions during embryogenesis. in Development (Cambridge, England) 2011 (PubMed)
    Show all 8 Pubmed References

  4. Human Monoclonal Desmin Primary Antibody for IHC (fro), IHC - ABIN335360 : Dispersyn, Geuens, Ver Donck, Ramaekers, Borgers: Adult rabbit cardiomyocytes undergo hibernation-like dedifferentiation when co-cultured with cardiac fibroblasts. in Cardiovascular research 2001 (PubMed)
    Show all 8 Pubmed References

  5. Human Monoclonal Desmin Primary Antibody for IHC (fro), IHC - ABIN335226 : Pieper, Schaart, Krimpenfort, Henderik, Moshage, van de Kemp, Ramaekers, Berns, Bloemendal: Transgenic expression of the muscle-specific intermediate filament protein desmin in nonmuscle cells. in The Journal of cell biology 1989 (PubMed)
    Show all 8 Pubmed References

  6. Chicken Polyclonal Desmin Primary Antibody for IF (p), IHC (p) - ABIN736566 : Luo, Wu, Ye, Li, Hao, Kong, Zheng, Lin, Nie, Zhang: The transient expression of miR-203 and its inhibiting effects on skeletal muscle cell proliferation and differentiation. in Cell death & disease 2014 (PubMed)
    Show all 5 Pubmed References

  7. Chicken Monoclonal Desmin Primary Antibody for IF, WB - ABIN967294 : Broers, Carney, Klein Rot, Schaart, Lane, Vooijs, Ramaekers: Intermediate filament proteins in classic and variant types of small cell lung carcinoma cell lines: a biochemical and immunochemical analysis using a panel of monoclonal and polyclonal antibodies. in Journal of cell science 1987 (PubMed)
    Show all 4 Pubmed References

  8. Human Monoclonal Desmin Primary Antibody for IHC, ELISA - ABIN969477 : Shardonofsky, Capetanaki, Boriek: Desmin modulates lung elastic recoil and airway responsiveness. in American journal of physiology. Lung cellular and molecular physiology 2006 (PubMed)
    Show all 2 Pubmed References

  9. Human Monoclonal Desmin Primary Antibody for IHC, ELISA - ABIN965993 : Huang, Li, Foster, Lemanski, Dube, Zhang, Lemanski: Protein kinase C-mediated desmin phosphorylation is related to myofibril disarray in cardiomyopathic hamster heart. in Experimental biology and medicine (Maywood, N.J.) 2002 (PubMed)
    Show all 2 Pubmed References

  10. Human Polyclonal Desmin Primary Antibody for IHC (fp), IHC (fro) - ABIN965994 : Geisler, Weber: Purification of smooth-muscle desmin and a protein-chemical comparison of desmins from chicken gizzard and hog stomach. in European journal of biochemistry / FEBS 1981 (PubMed)
    Show all 3 Pubmed References

More Antibodies against Desmin Interaction Partners

Zebrafish Desmin (DES) interaction partners

  1. Desmin intermediate filaments are required for normal active force generation.

  2. Desmin distribution during muscle maturation changes from dispersed aggregates to a perinuclear concentration to striated (show NSDHL Antibodies) afterwards.

Human Desmin (DES) interaction partners

  1. demonstrate that the expression of mutant desmin causes disruption of the extrasarcomeric desmin cytoskeleton and extensive mitochondrial abnormalities regarding subcellular distribution, number and shape

  2. Mutation in the Core Structure of Desmin Intermediate Filaments Affects Myoblast Elasticity

  3. Data show that the filament elongation of both desmin and keratin K8/K18 (show KRT18 Antibodies) proceeds very similar to that of vimentin (show VIM Antibodies).

  4. Cdk1 (show CDK1 Antibodies)-induced desmin phosphorylation is required for efficient separation of desmin-IFs and generally detected in muscular mitotic cells in vivo.

  5. Desmin, Lamin A/C, MMP9, and histone H4 were upregulated in the placental villi of women experiencing early pregnancy loss.

  6. Increasing desmin abnormalities were correlated with diastolic dysfunction progression.

  7. expression level of mutant versus wild-type desmin in mouse model as well as in skeletal muscle specimens derived from human R350P desminopathies; findings demonstrate missense-mutant desmin inflicts changes of the subcellular localization and turnover of desmin itself and of direct desmin-binding partners

  8. Results propose that the mutations affect desmin structure and cause its aberrant folding and subsequent aggregation, triggering disruption of myofibrils organization.

  9. identified disruption of the desmin system in gastrocnemius myofibers as an index of the myopathy and limitation of muscle function in patients with peripheral artery disease.

  10. The desmin intermediate filament network plays a major role in striated (show NSDHL Antibodies) muscle development and maintenance by integrating and coordinating most cellular components necessary for proper mechanochemical signaling, organelle cross-talk, energy production and trafficking processes required for proper tissue homeostasis. [Review]

Mouse (Murine) Desmin (DES) interaction partners

  1. demonstrate that the expression of mutant desmin causes disruption of the extrasarcomeric desmin cytoskeleton and extensive mitochondrial abnormalities regarding subcellular distribution, number and shape

  2. The disease-mutant desmin variants E245D and T453I exhibited increased binding affinity for nebulette (show NEBL Antibodies), delayed filament assembly kinetics, and caused significant weakening of networks.

  3. desmin and alphaBeta-crystallin are localized at sarcoplasmic reticulum (SR)-mitochondria-associated membranes (MAMs), where they interact with VDAC, Mic60 - the core component of mitochondrial contact site and cristae organizing system (MICOS) complex - and ATP synthase, suggesting that these associations could be crucial in mitoprotection at different levels.

  4. Complete lack or markedly decreased expression of mutant R349P desmin impairs the structural and functional integrity of neuromuscular endplates.

  5. Cdk1 (show CDK1 Antibodies)-induced desmin phosphorylation is required for efficient separation of desmin-IFs and generally detected in muscular mitotic cells in vivo.

  6. the coordinated up-regulations of desmin and alpha- actinin (show ACTN1 Antibodies) specifically in the early stage of diastolic heart failure mouse models indicate a novel myocardial response.

  7. E413K mutation induces desmin network disorganization, desmin aggregate formation and alters the traction forces generation of single myoblasts.

  8. This study identifies desmin as a new Asb2b target for proteasomal degradation in cardiomyocytes and suggests that accumulation of desmin could contribute to UPS impairment in Hypertrophic cardiomyopathy mice and patients

  9. found that inhibition of the Rac1 pathway (a G protein signaling pathway involved in diverse cellular processes), antioxidant treatment, and stimulation of macroautophagy reduced desmin aggregation by up to 75% in this model

  10. This demonstration of biomechanical integration by the desmin intermediate filament system suggests that it plays an active biological role in muscle in addition to its accepted structural role

Cow (Bovine) Desmin (DES) interaction partners

  1. Results show that expression of desmin increased during the late fattening stage of of hanwoo steers and it contributes to the muscle contractile apparatus.

Desmin (DES) Antigen Profile

Protein Summary

This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.

Gene names and symbols associated with anti-Desmin (DES) Antibodies

  • desmin-like (LOC100059397) antibody
  • desmin (DES) antibody
  • desmin (des-b) antibody
  • desmin, gene 1 (des.1) antibody
  • desmin (des) antibody
  • desmin (LOC100220724) antibody
  • desmin-like (LOC100402007) antibody
  • desmin a (desma) antibody
  • desmin (Des) antibody
  • desmin b (desmb) antibody
  • desmin, gene 1 (des.1-a) antibody
  • desmin, gene 2 (des.2) antibody
  • cb290 antibody
  • cmd1i antibody
  • CSM1 antibody
  • CSM2 antibody
  • des antibody
  • des-a antibody
  • des-b antibody
  • desm antibody
  • desmin antibody
  • fb59a12 antibody
  • LGMD2R antibody
  • LOC100220724 antibody
  • MGC52614 antibody
  • MGC75911 antibody
  • MGC80853 antibody
  • wu:fb59a12 antibody
  • wu:fc11d08 antibody
  • zgc:109859 antibody
  • zgc:154009 antibody

Protein level used designations for anti-Desmin (DES) Antibodies

desmin , desmin, gene 1 , desmin-like , intermediate filament protein , muscle-specific intermediate filament desmin , fc11d08

GENE ID SPECIES
100059397 Equus caballus
100137488 Papio anubis
446868 Xenopus laevis
394739 Xenopus (Silurana) tropicalis
470657 Pan troglodytes
100136041 Oncorhynchus mykiss
100220724 Taeniopygia guttata
100402007 Callithrix jacchus
30148 Danio rerio
100586972 Nomascus leucogenys
395906 Gallus gallus
1674 Homo sapiens
64362 Rattus norvegicus
497091 Canis lupus familiaris
13346 Mus musculus
101097010 Felis catus
280765 Bos taurus
101117308 Ovis aries
100328890 Oryctolagus cuniculus
396725 Sus scrofa
100733478 Cavia porcellus
101837949 Mesocricetus auratus
768287 Danio rerio
379869 Xenopus laevis
733312 Xenopus laevis
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