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DPPA3 encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. Additionally we are shipping DPPA3 Proteins (5) and many more products for this protein.
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Human Polyclonal DPPA3 Primary Antibody for WB - ABIN2476603
Bowles, Teasdale, James, Koopman: Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. in Cytogenetic and genome research 2003
DPPA3 is a maternal factor (show ZAR1 Antibodies) important for correct epigenetic remodeling and normal embryonic development in cattle, indicating that the role of DPPA3 during early development is conserved between species.
Data suggest enforced expression of Stella into normal cells induces not only global DNA demethylation but also neoplastic transformation and increases metastatic ability; these changes involve altered regulation of neoplastic gene expression.
Considering that impaired DNA methylation (show HELLS Antibodies) profiles are associated with various developmental or disease phenomena, Stella may be a powerful tool with which to study the biological effects of global DNA hypomethylation
a role for STELLA in facilitating germline and endodermal differentiation of human ES cells
human adult tissue-specific transcripts originate via retrotransposition of the pluripotent cell-specific gene, Dppa3
These results demonstrate that PGC7/Stella is indispensable for the maintenance of methylation involved in epigenetic reprogramming after fertilization.
In mice, a targeted mutation results in reduced female fertility and (show MTA2 Antibodies)may function as a mammalian maternal effect gene.
In mice, knockout experiments show this gene may be a maternal factor (show ZAR1 Antibodies) in cleavage stage embryogenesis.
In-depth transcriptome analysis of this mESC state reveals Dppa3 as a direct downstream target of Tbx3 (show TBX3 Antibodies).We show that Tbx3 (show TBX3 Antibodies), a downstream target of Wnt (show WNT2 Antibodies) signaling, fine tunes these divergent roles of Wnt (show WNT2 Antibodies) signaling in mESCs
Dppa3 has a critical role in generation of fully reprogrammed iPS (show SLC27A4 Antibodies) cells and maintenance of Dlk1 (show DLK1 Antibodies)-Dio3 (show DIO3 Antibodies) imprinting
Stella protects maternal chromosomes from aberrant epigenetic modifications to ensure early embryogenesis.
Chromocenter formation is impaired in Stella-null embryos.
we propose that Dppa3 is involved in the Tet-mediated active demethylation process during reprogramming of primordial germ cells.
PGC7 protects 5mC from Tet3 (show TET3 Antibodies)-mediated conversion to 5hmC by binding to maternal chromatin containing dimethylated histone H3 (show HIST3H3 Antibodies) lysine 9 (H3K9me2) in mice
These Dppa3-MCM strains offer valuable opportunities to explore gene function in both loss-of-function and gain-of-function experiments at a variety of time points during germ cell development.
DPPA3 is an essential factor for the production of functional oocytes through transcriptional repression and chromatin condensation.
Data show that STELLA was found in both the nucleus and cytoplasm in a variety of cell types, both within and outside of the putative primordial germ cells (PGCs)trajectory.
Data show that Stella is specifically expressed in preimplantation embryos and in the germline.
This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X.
developmental pluripotency-associated protein 3
, stella-related protein
, developmental pluripotency associated 3
, compaction-associated protein 1
, primordial germ cell 7
, primordial germ cell protein 7