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anti-Dihydrolipoyl Transacetylase (DLAT) Antibodies

DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). Additionally we are shipping Dihydrolipoyl Transacetylase Kits (11) and Dihydrolipoyl Transacetylase Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DLAT 1737 P10515
DLAT 81654 P08461
DLAT 235339 Q8BMF4
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Top anti-Dihydrolipoyl Transacetylase Antibodies at antibodies-online.com

Showing 10 out of 55 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Caenorhabditis elegans Rabbit Un-conjugated WB WB Suggested Anti-DLAT Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate WB Suggested Anti-DLAT  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: HepG2 cell lysate  DLAT is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-DLAT Antibody Titration: 5.0ug/mlPositive Control: Jurkat cell lysate Sample Type: Huh7 lysate (50ug)Primary Antibody Dilution: 1:200Image Submitted By: Partha KasturiUniversity of Kansas Medical Center 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated ICC, IP, WB 100 μL Log in to see 8 to 9 Days
$392.86
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB DLAT Antibody (C-term) (ABIN651534) western blot analysis in K562,HepG2,Jurkat cell line lysates (35 µg/lane). This demonstrates the DLAT antibody detected the DLAT protein (arrow). DLAT Antibody (C-term) (ABIN651534) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Dog Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated WB DLAT antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$347.60
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$356.40
Details

DLAT Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Rat (Rattus)


Mouse (Murine) ,


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Top referenced anti-Dihydrolipoyl Transacetylase Antibodies

  1. Caenorhabditis elegans (C. elegans) Polyclonal DLAT Primary Antibody for WB - ABIN2777102 : Korotchkina, Patel: Binding of pyruvate dehydrogenase to the core of the human pyruvate dehydrogenase complex. in FEBS letters 2008 (PubMed)

  2. Chicken Polyclonal DLAT Primary Antibody for IHC, WB - ABIN2777101 : Head, Brown, Zolkipli, Shahdadpuri, King, Clayton, Brown: Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency. in Annals of neurology 2005 (PubMed)

More Antibodies against Dihydrolipoyl Transacetylase Interaction Partners

Human Dihydrolipoyl Transacetylase (DLAT) interaction partners

  1. ongoing activation of PDCE2-specific B-cells in primary biliary cirrhosis

  2. Results show that DLAT and ACAT2 (show ACAT2 Antibodies) as upstream acetyltransferases of K76 and K294 in 6PGD (show PGD Antibodies) protein.

  3. These findings were used to identify potentially antigenic sequences within PDC-E2 (an important hepatic autoantigen) that contain a DR0801 motif.

  4. Solution structure and characterisation of the human pyruvate dehydrogenase (show PDP Antibodies) complex core assembly

  5. Data suggest that the catalytic site of pyruvate dehydrogenase (show PDP Antibodies) complex E2 rather than the previously reported lipoyl binding peptide (show HP Antibodies) may contain immunodominant epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis.

  6. a novel HLA-A*0201-restricted epitope PDC-E2 165 to 174 was defined in patients with primary biliary cirrhosis.

  7. study of facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase

  8. model of the pyruvate dehydrogenase (show PDP Antibodies) complex formed by E2 and E2 plus the E3-binding protein (show PDHX Antibodies) and binding of the E1 and E3 components

  9. Having found that there is an excellent and almost unique match between the PDC-E2 autoepitope and a sequence in mycobacterial hsp65s, we tested the corresponding peptides for cross-reactivity using sera from 90 Spanish and British PBC patients.

  10. This study report two unrelated patients with pyruvate dehydrogenase (show PDP Antibodies) deficiency caused by defects in the E2 subunit.

Zebrafish Dihydrolipoyl Transacetylase (DLAT) interaction partners

  1. Deficiency of dihydrolipoamide S-acetyltransferase (Dlat) results in neurological dysfunction, congenital lactic acidosis, growth retardation, and early death.

Mouse (Murine) Dihydrolipoyl Transacetylase (DLAT) interaction partners

  1. breach of tolerance to PDC-E2 is probably the first event in the natural history of primary biliary cirrhosis in genetically susceptible hosts.

  2. a novel function of pyruvate dehydrogenase (show PDP Antibodies) complex E2 in the nucleus in up-regulating the transactivating ability of STAT5 (show STAT5A Antibodies)

Dihydrolipoyl Transacetylase (DLAT) Antigen Profile

Protein Summary

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

Gene names and symbols associated with DLAT

  • CG5261 gene product from transcript CG5261-RB (CG5261) antibody
  • dihydrolipoamide S-acetyltransferase (dlat) antibody
  • dihydrolipoamide S-acetyltransferase (DLAT) antibody
  • dihydrolipoamide S-acetyltransferase (Dlat) antibody
  • dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (dlat) antibody
  • dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat) antibody
  • 6332404G05Rik antibody
  • anon-WO0118547.121 antibody
  • DLAT antibody
  • DLTA antibody
  • Dmel\\CG5261 antibody
  • EP(2)0816 antibody
  • EP816 antibody
  • PDC-E2 antibody
  • PDCE2 antibody
  • wu:fc14f10 antibody
  • wu:fc21f08 antibody
  • wu:fc86g11 antibody
  • wu:fj57d06 antibody

Protein level used designations for DLAT

CG5261-PA , CG5261-PB , CG5261-PC , CG5261-PD , CG5261-PE , CG5261-PF , Dihydrolipoyllysine-residue acetyltransferase , dihydrolipoamide acetyltransferase , dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) , 70 kDa mitochondrial autoantigen of primary biliary cirrhosis , E2 component of pyruvate dehydrogenase complex , M2 antigen complex 70 kDa subunit , PBC , dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex , dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial , dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial , pyruvate dehydrogenase complex component E2 , dihydrolipoyllysine-residue acetyltransferase , E2 , PDC-E2 , PDCE2 , fc86g11 , fj57d06 , no optokinetic nystagmus a , no optokinetic response b , noa , nrb

GENE ID SPECIES
34021 Drosophila melanogaster
398314 Xenopus laevis
419796 Gallus gallus
1737 Homo sapiens
489406 Canis lupus familiaris
397054 Sus scrofa
512723 Bos taurus
81654 Rattus norvegicus
100349212 Oryctolagus cuniculus
324201 Danio rerio
235339 Mus musculus
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