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Dihydropyrimidinase-Like 2 Proteins (DPYSL2)

DPYSL2 encodes a member of the collapsin response mediator protein family. Additionally we are shipping Dihydropyrimidinase-Like 2 Antibodies (127) and Dihydropyrimidinase-Like 2 Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DPYSL2 12934 O08553
DPYSL2 25416 P47942
DPYSL2 1808 Q16555
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Top Dihydropyrimidinase-Like 2 Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days

DPYSL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus) ,

Human , ,

More Proteins for Dihydropyrimidinase-Like 2 (DPYSL2) Interaction Partners

Mouse (Murine) Dihydropyrimidinase-Like 2 (DPYSL2) interaction partners

  1. We propose that CRMP2 could contribute to long-lasting synaptic plasticity.

  2. This study shows that in young adult mice, motor and sensory functions lost by SCI can be recovered with a single genetic mutation to inhibit CRMP2 phosphorylation

  3. Study showed that axon degeneration is an early and dominant feature in dopaminergic neurons treated with 1-methyl-4-phenylpyridiniumion (MPP+), and that the Akt/GSK-3beta/CRMP-2 pathway is involved in axon degeneration induced by MPP+

  4. Clear differences in CRMP2 protein abundance and degradation product/short isoform were observed between ischemic core and penumbra (show TSPAN33 Proteins) and also compared to the contralateral healthy tissues after PACAP38 (show ADCYAP1 Proteins) or saline treatment.

  5. Glycogen synthase kinase 3beta has a role in microtubule remodeling in compensatory glomerular adaptation to podocyte depletion through Tau and CRMP2

  6. Levels of total GSK3 were decreased in the Huntington disease (show HTT Proteins)-affected frontal cortex and this correlated with decreased phosphorylated CRMP2.

  7. Long-term vitamin E-deficiency led to significantly increased expression of the phosphorylated form of collapsin (show SEMA3A Proteins) response mediator protein (CRMP)-2 compared to short-term deficiency.

  8. Noncanonical kainate receptor signaling influences neuronal development by modulating CRMP2 activity.

  9. a novel regulatory mechanism that utilizes CRMP2 SUMOylation to choreograph NaV1.7 (show SCN9A Proteins) trafficking.

  10. A novel glycogen synthase kinasealpha/beta CRMP-2 pathway is identified that connects neuronal activity to dendritic growth.

Human Dihydropyrimidinase-Like 2 (DPYSL2) interaction partners

  1. These data identify a novel oncogenic mechanism where CDK5 (show CDK5 Proteins) activation induces CRMP2A phosphorylation in the nuclei of tumour cells

  2. polymorphisms of the DPYSL2 gene in humans may be associated with the development of schizophrenia.

  3. Functional variants in DPYSL2 sequence increase risk of schizophrenia and suggest a link to mTOR (show FRAP1 Proteins) signaling

  4. Changes for CRMP2, TCP1epsilon, TPM2 (show TPM2 Proteins) and 14-3-3gamma (show YWHAG Proteins) were confirmed in experimental tumors and in a series of 28 human SI-NETs.

  5. Reduced CRMP2 expression and elevated expression of nuclear phosphorylated CRMP2 may be associated with breast cancer progression.

  6. Levels of total GSK3 were decreased in the Huntington disease (show HTT Proteins)-affected frontal cortex and this correlated with decreased phosphorylated CRMP2.

  7. High dihydropyrimidinase-related protein 2 expression is associated with lung cancer.

  8. genetic variants in DPYSL2 may play a role in susceptibility to alcohol dependence.

  9. A specific and reversible intermolecular Cys (show DNAJC5 Proteins)-504-Cys (show DNAJC5 Proteins)-504 dithiol-disulfide switch in homotetrameric CRMP2 determines two conformations of the quaternary CRMP2 complex that controls axonal outgrowth and thus neuronal development.

  10. CRMP-2-dependent regulation of ROCK II (show ROCK2 Proteins) activity is mediated through interaction of the CRMP-2L N terminus with the ROCK II (show ROCK2 Proteins) catalytic domain as well as by GSK3-dependent phosphorylation of CRMP-2.

Zebrafish Dihydropyrimidinase-Like 2 (DPYSL2) interaction partners

  1. phosphorylation of Dpysl2 and Dpysl3 (show DPYSL3 Proteins) by Cyclin-dependent kinase 5 (show CDK5 Proteins) and dual-specificity tyrosine-phosphorylated and regulated kinase 2 is required for correct positioning of CaP motor neurons in the zebrafish spinal cord

  2. These results suggest that the phosphorylation of Dpysl2 and Dpysl3 (show DPYSL3 Proteins) by Cdk5 (show CDK5 Proteins) and DYRK2 (show DYRK2 Proteins) is required for the proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish embryos.

  3. From 20 somites through 30 hpf CRMP2 is expressed in the dorsal rostral cluster of the telencephalon, the ventral rostral cluster of the diencephalon, the ventral caudal cluster of the mesencephalon, and the hindbrain clusters.

Dihydropyrimidinase-Like 2 (DPYSL2) Protein Profile

Protein Summary

This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with DPYSL2

  • dihydropyrimidinase-like 2 (DPYSL2)
  • cysteine repeat modular protein 2, putative (PfCRMP2)
  • dihydropyrimidinase-like 2 (dpysl2)
  • dihydropyrimidinase-like 2 (Dpysl2)
  • dihydropyrimidinase-like 2b (dpysl2b)
  • AI851130 protein
  • CRMP-2 protein
  • Crmp2 protein
  • CRMP 2 protein
  • CRMP2A protein
  • DHPRP2 protein
  • dpysl2 protein
  • DRP-2 protein
  • DRP2 protein
  • Musunc33 protein
  • N2A3 protein
  • PCRMP-2 protein
  • PCRMP 2 protein
  • PCRMP2 protein
  • PfCRMP-2 protein
  • PfCRMP 2 protein
  • TOAD-64 protein
  • ULIP-2 protein
  • ULIP2 protein
  • unc-33 protein
  • unc33 protein

Protein level used designations for DPYSL2

collapsin response mediator protein 2 , dihydropyrimidinase-like 2 , DRP-2 , dihydropyrimidinase-related protein 2 , dihydropyrimidinase-related protein 2-like , ULIP-2 , unc-33-like phosphoprotein 2 , CRMP-2 , turned on after division 64 kDa protein , turned on after division, 64 kDa protein , collapsin response mediator protein hCRMP-2 , collapsin response mediator protein CRMP-62 , collapsin response mediator protein-2A , neural-specific protein NSP60 , turned on after division 64

554340 Felis catus
2655054 Plasmodium falciparum 3D7
100158561 Xenopus (Silurana) tropicalis
100172763 Pongo abelii
464070 Pan troglodytes
712368 Macaca mulatta
100351135 Oryctolagus cuniculus
100391260 Callithrix jacchus
100580649 Nomascus leucogenys
12934 Mus musculus
25416 Rattus norvegicus
1808 Homo sapiens
398815 Xenopus laevis
395155 Gallus gallus
486107 Canis lupus familiaris
533746 Bos taurus
553412 Danio rerio
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